Description

Product Description

Glutathione Oxidized Disodium (CAS No. 103239-24-3) is the disodium salt form of oxidized glutathione (GSSG), produced by the oxidation of reduced glutathione (GSH). As one of the most crucial antioxidants in living cells, glutathione maintains cellular redox balance, detoxifies xenobiotics, and protects biomolecules against oxidative damage.

The oxidized disodium form (GSSG-Na?) is particularly valuable for laboratory applications where solubility and stability are required. It serves as a research standard for studying redox homeostasis, oxidative stress, detoxification mechanisms, and cellular adaptive responses.

Biological Importance

• Redox Buffer: GSSG is central in maintaining the cellular redox state through its reversible interconversion with GSH via glutathione reductase.

• Oxidative Stress Marker: The GSH/GSSG ratio is widely used as a biomarker for oxidative stress in cells and tissues.

• Detoxification: Glutathione conjugates with electrophilic compounds, aiding in xenobiotic clearance.

• Signal Transduction: GSSG and GSH influence redox-sensitive signaling pathways, transcription factors, and protein thiol modifications.

Research Applications

• Redox Biology: Study of GSH/GSSG cycling and oxidative damage.

• Oxidative Stress: Experimental models for aging, neurodegeneration, and cardiovascular diseases.

• Detoxification Pathways: Investigation of glutathione-dependent enzyme systems.

• Oncology: Cancer metabolism and drug resistance research.

• Neuroprotection: Protective mechanisms against excitotoxicity and oxidative damage in neurons.

Supplied in GMP-compliant quality, Glutathione Oxidized Disodium guarantees high purity, consistent activity, and reproducibility, essential for cellular, biochemical, and translational studies.

Disclaimer: For laboratory research use only. Not for human or veterinary use.

Product Specifications

Mechanism of Action & Research Applications

Mechanism of Action

Glutathione Oxidized Disodium functions through the GSH/GSSG redox cycle:

1. Electron Carrier – GSSG forms when two GSH molecules donate electrons to neutralize reactive oxygen species (ROS).

2. Glutathione Reductase Recycling – GSSG is recycled back to GSH by glutathione reductase using NADPH.

3. Signal Transduction – Alters protein thiol states and redox-sensitive transcription factors (e.g., NF-?B, Nrf2).

Research Applications

• Oxidative Stress Models: Understanding redox imbalance in neurodegenerative, cardiovascular, and metabolic diseases.

• Cellular Defense Mechanisms: Studying detoxification via glutathione peroxidase and glutathione S-transferase.

• Oncology Studies: Investigating tumor cell resistance to chemotherapy via glutathione-dependent pathways.

• Neuroprotection Research: Exploring glutathione-based defense in Parkinson’s, Alzheimer’s, and excitotoxicity.

• Aging Biology: Modeling age-related oxidative stress and redox imbalance.

  

Side Effects (For Reference in Research Models)

In preclinical and laboratory models, Glutathione Oxidized Disodium may exhibit:

• Dose-dependent redox shifts affecting cell signaling.

• Altered antioxidant defenses at supraphysiological concentrations.

• Potential cytotoxicity under excessive oxidative or reductive stress conditions.

These effects are observed only in experimental contexts and do not apply to clinical use.

Disclaimer

For laboratory research use only. Not for human or veterinary use.

Keywords

• Glutathione Oxidized Disodium

• CAS 103239-24-3 Glutathione

• GSSG disodium salt

• Oxidized glutathione peptide

• Intracellular antioxidant research

• GMP supplier oxidized glutathione

• Redox biology compound

• Oxidative stress research peptide

• Cellular detoxification research

• Neuroprotection and oncology redox compound