Description

Granisetron Hydrochloride Dispersible Tablets Product Specifications

Granisetron Hydrochloride Dispersible Tablets Mechanism & Indications

Granisetron is a selective 5HT receptor antagonist that blocks serotonin effects on vagal nerve terminals and in the brain’s chemoreceptor trigger zone. It’s indicated for prevention of nausea and vomiting associated with chemotherapy, radiation therapy, and postoperative care webmd.com+7medlineplus.gov+7pdf.hres.ca+7dailymed.nlm.nih.gov.

Granisetron Hydrochloride Dispersible Tablets Pharmacology & Usage

• Dosage: Typically 1mg orally ~1hour before chemotherapy or radiation; may repeat dose after 12hours based on regimen

• Absorption: Oral tablets, dispersible for ease of administration; onset ~30–60min, half-life 9hours

• Metabolism: Primarily via hepatic CYP3A4, excreted in urine (~11% unchanged)

Warnings & Interactions

• Avoid in: Patients with known hypersensitivity to granisetron or excipients.

• QT prolongation: Use caution with drugs affecting cardiac conduction (e.g. SSRIs, antipsychotics, fluconazole)

• Serotonin syndrome: Potential risk when combined with serotonergic agents (e.g., SSRIs, lithium, tramadol) .

Side Effects

From clinical data and pharmacology references:

• Common (5%): Headache, constipation, diarrhea, fatigue, abdominal discomfort, sleep disturbances

• Serious: Rare QT prolongation, allergic reactions (rash, dyspnea)

Storage & Handling

• Store at 20–25°C, keep container tightly closed and protected from light

• Dispense in original packaging; each tablet disperses completely in water for ease of ingestion.

References

• MedlinePlus overview on granisetron uses and mechanism

• DailyMed label details: dosage, warnings, pharmacology

• Drugs.com overview: side effects & serotonin warnings