Description

Product Description

H-Gly-Pro-Hyp-OH, also known as Tripeptide-29, is a short collagen-derived peptide composed of glycine, proline, and hydroxyproline. It represents one of the fundamental bioactive sequences released during collagen breakdown and plays a vital role in maintaining dermal elasticity and hydration. This tripeptide has been extensively investigated in cosmetic research for its ability to protect skin cells against UVB-induced oxidative stress, promote collagen synthesis, and improve the biomechanical strength of connective tissues.

In the context of cosmetic science, H-Gly-Pro-Hyp-OH is recognized for its strong anti-aging and photo-protective potential. Studies have demonstrated that it helps restore collagen network integrity, reduces matrix metalloproteinase (MMP) activation, and prevents the degradation of the extracellular matrix (ECM) that typically occurs during skin aging and chronic UV exposure. By stabilizing dermal fibroblast function, H-Gly-Pro-Hyp-OH contributes to maintaining skin firmness, smoothness, and elasticity.

When used in cosmetic formulation research, Tripeptide-29 is valued for its biocompatibility, stability, and skin penetration characteristics. It mimics endogenous collagen fragments that signal fibroblasts to synthesize new collagen fibers, effectively acting as a natural messenger to rejuvenate skin from within. In vitro and ex vivo studies have confirmed that H-Gly-Pro-Hyp-OH enhances type I collagen synthesis and reduces wrinkle formation caused by photodamage.

Additionally, this tripeptide exhibits strong antioxidant properties, scavenging reactive oxygen species (ROS) and protecting against lipid peroxidation induced by UVB radiation. Through these mechanisms, H-Gly-Pro-Hyp-OH helps counteract oxidative stress — a major contributor to premature skin aging.

From a biochemical standpoint, the hydroxyproline residue in H-Gly-Pro-Hyp-OH is critical for its conformational stability and ability to bind specific collagen receptors on fibroblast membranes. This interaction activates signaling pathways that promote matrix repair and dermal regeneration.

As a research-grade cosmetic peptide, H-Gly-Pro-Hyp-OH is ideal for studies focused on:

• UV-induced skin aging and photo-protection mechanisms

• Collagen synthesis and extracellular matrix regeneration

• Anti-wrinkle and dermal elasticity improvement models

• Formulation of peptide-based anti-aging and repair agents

Overall, Tripeptide-29 serves as a benchmark compound in peptide-based anti-aging research, demonstrating efficacy in maintaining dermal structure and mitigating the biochemical pathways associated with photoaging.

Product Specifications

Mechanism of Action

The mechanism of action of H-Gly-Pro-Hyp-OH (Tripeptide-29) is primarily based on its role as a collagen-derived signal molecule. When collagen fibers are naturally degraded in the skin, short peptides like H-Gly-Pro-Hyp-OH are released and act as biological messengers, stimulating fibroblast activity and new collagen formation. This peptide mimics the body’s intrinsic repair signals, leading to enhanced extracellular matrix turnover and dermal restoration.

At the cellular level, H-Gly-Pro-Hyp-OH interacts with integrin and receptor-mediated pathways to trigger fibroblast proliferation and type I collagen synthesis. The proline and hydroxyproline residues stabilize its secondary structure, allowing high receptor affinity and efficient biological signaling. Activation of TGF-β/SMAD and MAPK pathways further amplifies its regenerative effects.

In UVB-damaged skin models, Tripeptide-29 inhibits matrix metalloproteinases (MMP-1 and MMP-3) that degrade collagen and elastin. By suppressing these enzymes, it helps maintain dermal matrix integrity and prevents wrinkle formation. Additionally, its antioxidant capability helps neutralize free radicals, reducing lipid peroxidation and DNA damage caused by UV stress.

Recent research also suggests that H-Gly-Pro-Hyp-OH promotes the synthesis of hyaluronic acid and glycosaminoglycans, improving dermal hydration and elasticity. It supports the organization of collagen fibrils, making them more compact and resistant to fragmentation, thereby enhancing the overall tensile strength of the skin.

Collectively, these mechanisms underline H-Gly-Pro-Hyp-OH’s multifaceted biological role in photo-protection, anti-aging, and dermal repair studies.

Side Effects

In research environments, H-Gly-Pro-Hyp-OH (Tripeptide-29) has exhibited an excellent safety profile. It is non-cytotoxic, non-immunogenic, and shows high skin compatibility in in vitro studies. Since it is composed of natural amino acids commonly found in the human body, it presents minimal risk of irritation or sensitization when used within research concentrations.

No adverse effects have been reported in standard in vitro dermal toxicity assays. However, researchers are advised to use protective measures and adhere to laboratory safety protocols. As with all laboratory-only peptides, it is not approved for clinical or topical consumer use.

Keywords

H-Gly-Pro-Hyp-OH, Tripeptide-29, collagen peptide, anti-aging peptide, UV protection peptide, peptide supplier China, cosmetic raw material, bulk peptide manufacturer, collagen regeneration research, peptide wholesale factory.

Shipping Guarantee

All Tripeptide 29 shipments are handled using validated cold-chain logistics to preserve peptide integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage.

Trade Assurance

We Tripeptide 29 ensure product authenticity, verified ≥99% purity, and compliance with analytical standards (HPLC, MS, and NMR). Each batch is supplied with a Certificate of Analysis (CoA). Our trade assurance policy guarantees replacement or refund for any deviation from listed specifications.

Payment Support

We Tripeptide 29 provide flexible and secure global payment options to support international research transactions. Accepted payment methods include PayPal, major credit cards (Visa, MasterCard, American Express), telegraphic transfer (T/T), and cryptocurrencies (USDT, Bitcoin, Ethereum). All transactions are protected by industry-standard encryption and verified payment gateways to ensure confidentiality and fund security.

Disclaimer

All Tripeptide 29 products listed are intended for laboratory research use only and not for human or veterinary use. They are not drugs, medical devices, or diagnostics and should not be administered to humans or animals. Researchers must handle all materials in accordance with institutional biosafety and chemical safety guidelines. The information provided is for scientific reference only and does not imply therapeutic efficacy, safety, or regulatory approval.