Description

Product Description

Hexapeptide-10 is a bioactive amino acid derivative peptide that has gained prominence in cosmetic research due to its multifaceted anti-aging and skin-rejuvenating properties. Structurally, Hexapeptide-10 consists of six amino acid residues arranged in a specific sequence that facilitates both skin penetration and interaction with dermal fibroblasts and keratinocytes. Its small molecular size allows it to reach the deeper layers of the skin, particularly the dermis, where it can modulate extracellular matrix (ECM) synthesis and improve structural integrity.

One of the most critical functions of Hexapeptide-10 is its ability to stimulate collagen production, particularly types I and III, which are essential for maintaining dermal density and resilience. Collagen is the primary structural protein in the skin, responsible for tensile strength, elasticity, and overall firmness. As aging progresses, collagen production naturally declines, leading to wrinkles, sagging, and loss of skin elasticity. By promoting fibroblast activity and upregulating collagen synthesis, Hexapeptide-10 counteracts these age-related changes, resulting in visibly firmer, smoother, and more youthful skin.

In addition to collagen, Hexapeptide-10 enhances the synthesis of other ECM proteins such as elastin, fibronectin, and glycosaminoglycans. Elastin contributes to the skin’s elasticity and recoil, fibronectin aids in cell adhesion and tissue repair, and glycosaminoglycans help maintain skin hydration by retaining water molecules within the dermis. The coordinated upregulation of these ECM components reinforces dermal architecture, strengthens the dermal-epidermal junction, and improves skin barrier function.

Hexapeptide-10 also exhibits antioxidant activity. Reactive oxygen species (ROS) generated by UV exposure, pollution, or metabolic processes can accelerate skin aging by damaging cellular structures and ECM proteins. Hexapeptide-10 mitigates oxidative stress by scavenging free radicals and reducing ROS-induced damage. This antioxidant property preserves fibroblast viability, supports cellular repair mechanisms, and delays premature cellular senescence, which is vital for maintaining youthful skin appearance.

Moreover, Hexapeptide-10 modulates keratinocyte function, influencing epidermal renewal and differentiation. Healthy keratinocyte activity ensures a uniform stratum corneum, which is essential for smooth skin texture and barrier integrity. By supporting keratinocyte proliferation and differentiation, Hexapeptide-10 contributes to a smoother, more even skin surface, reducing roughness, fine lines, and textural irregularities.

Hexapeptide-10 can also be used synergistically with other cosmetic actives, such as hyaluronic acid, vitamin C derivatives, peptides, and botanical extracts. These combinations enhance skin hydration, antioxidant protection, and ECM reinforcement. For example, pairing Hexapeptide-10 with hyaluronic acid amplifies moisture retention and dermal plumping, while combination with other bioactive peptides can accelerate anti-wrinkle effects and collagen deposition.

Recent research has explored the molecular mechanisms underlying Hexapeptide-10’s activity. The peptide has been shown to upregulate gene expression of key ECM proteins, activate signaling pathways such as MAPK and TGF-β that govern fibroblast activity, and influence transcription factors related to skin repair and anti-aging. Additionally, its effects on matrix metalloproteinases (MMPs) help reduce collagen degradation, further preserving dermal structure.

Cosmetic studies have demonstrated that formulations containing Hexapeptide-10 improve skin firmness, elasticity, and hydration within weeks of application. Repeated use leads to a cumulative reduction in wrinkle depth, improved skin tone, and overall rejuvenation. Its minimal cytotoxicity and high biocompatibility make it suitable for incorporation into serums, creams, masks, and other topical applications.

Hexapeptide-10’s versatility extends to sensitive skin research. Its gentle mechanism of action allows it to improve dermal integrity without provoking irritation, erythema, or inflammation, which is especially valuable for aging, photo-damaged, or reactive skin types.

In conclusion, Hexapeptide-10 is a multifunctional cosmetic peptide with the ability to enhance collagen synthesis, support ECM integrity, provide antioxidant protection, and improve keratinocyte function. Its combination of structural reinforcement, anti-aging, and protective properties make it a high-value ingredient for advanced skincare research and formulation development.

Product Specifications

Mechanism of Action

Hexapeptide-10 operates through multiple pathways to deliver comprehensive anti-aging effects:

1. Fibroblast Stimulation: The peptide directly activates fibroblasts in the dermis, enhancing their proliferation and promoting synthesis of collagen, elastin, and fibronectin. This reinforces skin structure and improves firmness.

2. ECM Remodeling: By modulating the expression of ECM proteins and inhibiting matrix metalloproteinases (MMPs), preserves collagen and elastin integrity, preventing degradation and promoting dermal resilience.

3. Dermal-Epidermal Junction Integrity:  strengthens the dermal-epidermal junction, maintaining skin thickness, reducing sagging, and supporting epidermal adhesion.

4. Antioxidant Defense: Hexapeptide-10 scavenges ROS and reduces oxidative stress-induced damage to dermal and epidermal cells, enhancing fibroblast longevity and preventing premature aging.

5. Keratinocyte Modulation: By regulating keratinocyte proliferation and differentiation, Hexapeptide-10 ensures a smoother epidermal surface, reduces roughness, and improves skin texture.

6. Signal Transduction: influences MAPK and TGF-β pathways, which control fibroblast function, ECM production, and tissue repair mechanisms.

7. Synergistic Interactions: When combined with other cosmetic peptides, vitamins, or hydrating agents, Hexapeptide-10 enhances anti-aging efficacy, providing cumulative improvements in skin elasticity, hydration, and wrinkle reduction.

8. Clinical Effects: Studies indicate that topical formulations with Hexapeptide-10 improve skin elasticity, reduce wrinkle depth, increase dermal hydration, and enhance overall skin smoothness within weeks of regular application.

   

Side Effects

Hexapeptide-10 is generally safe and well-tolerated for cosmetic and laboratory research purposes.

• Minimal irritation may occur in sensitive skin models but is rare.

• Store at recommended conditions (-20°C, protected from light and moisture).

• Avoid repeated freeze-thaw cycles to maintain activity.

• Use appropriate concentrations in formulations, typically in the range validated by in vitro and in vivo studies.

• No cytotoxicity reported at standard research concentrations.

Common precautionary measures for research-grade peptides apply, including personal protective equipment (PPE), adherence to institutional safety guidelines, and proper disposal of residues.

Keywords

Hexapeptide-10, Anti-Aging Peptide, Cosmetic Peptide, Collagen Booster, Skin Elasticity Enhancer, Fibroblast Activator, Skin Rejuvenation, Sensitive Skin Research, Freeze-Dried Powder, High-Purity Cosmetic Peptide, Cosmetic Raw Material, Online Peptide Supplier, Low-Cost Peptide Wholesale, China Peptide Manufacturer

Shipping Guarantee

All shipments are handled using validated cold-chain logistics to preserve peptide integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage.

Trade Assurance

We ensure product authenticity, verified ≥99% purity, and compliance with analytical standards (HPLC, MS, and NMR). Each batch is supplied with a Certificate of Analysis (CoA). Our trade assurance policy guarantees replacement or refund for any deviation from listed specifications.

Payment Support

We provide flexible and secure global payment options to support international research transactions. Accepted payment methods include PayPal, major credit cards (Visa, MasterCard, American Express), telegraphic transfer (T/T), and cryptocurrencies (USDT, Bitcoin, Ethereum). All transactions are protected by industry-standard encryption and verified payment gateways to ensure confidentiality and fund security.

Disclaimer

All products listed are intended for laboratory research use only and not for human or veterinary use. They are not drugs, medical devices, or diagnostics and should not be administered to humans or animals. Researchers must handle all materials in accordance with institutional biosafety and chemical safety guidelines. The information provided is for scientific reference only and does not imply therapeutic efficacy, safety, or regulatory approval.