Description

Product Description

Hexapeptide-9 is a synthetic oligopeptide consisting of six amino acids designed to target dermal matrix regeneration and skin rejuvenation at the molecular level. This peptide functions as a signaling molecule that interacts with fibroblasts in the dermis, promoting collagen synthesis and stimulating tissue repair mechanisms. With its ability to enhance extracellular matrix (ECM) production, Hexapeptide-9 plays a pivotal role in improving skin firmness, reducing wrinkle depth, and restoring youthful appearance in experimental cosmetic formulations.

In cosmetic research, Hexapeptide-9 is often studied for its potential to repair photoaged and mature skin by activating growth factors associated with collagen remodeling. It helps normalize cellular communication between epidermal and dermal layers, maintaining skin homeostasis and resilience under oxidative stress. Researchers have identified that Hexapeptide-9 contributes to increased production of type I and type III collagen, elastin, and other essential matrix proteins, resulting in a more compact and elastic dermal structure.

This peptide is highly valued in formulations aimed at wrinkle reduction, scar improvement, and post-inflammatory recovery due to its bio-repairing and collagen-inducing actions. In laboratory settings, Hexapeptide-9 is examined in combination with hyaluronic acid, vitamin C derivatives, and niacinamide to evaluate synergistic effects on fibroblast metabolism and ECM density. It is also considered a promising candidate for peptide-based anti-aging research focusing on gene expression modulation and structural protein synthesis.

With excellent skin compatibility and biocompatibility, Hexapeptide-9 demonstrates low cytotoxicity and high efficacy at micromolar concentrations. It is typically evaluated for its role in dermal regeneration, smoothing of fine lines, and promotion of epidermal turnover. In vitro studies reveal that this peptide upregulates the expression of transforming growth factor beta (TGF-β) and connective tissue growth factor (CTGF), both essential regulators in collagen biosynthesis and tissue repair.

Furthermore, Hexapeptide-9 research extends into wound-healing and post-laser treatment applications, as its regenerative effects contribute to faster re-epithelialization and improved skin texture. The peptide’s multifunctional actions — stimulating fibroblasts, improving elasticity, and reducing oxidative damage — make it a benchmark compound in peptide-based cosmetic innovation.

Product Specifications

Mechanism of Action

Hexapeptide-9 works primarily by activating fibroblasts, the skin’s primary producers of collagen and extracellular matrix components. By acting as a biochemical messenger, this peptide promotes communication between dermal cells, triggering pathways that increase collagen deposition and strengthen the skin’s structural network.

The peptide binds to receptors involved in cellular signaling cascades such as MAPK (mitogen-activated protein kinase) and SMAD pathways, resulting in enhanced transcription of collagen genes (COL1A1, COL3A1) and elastin synthesis. This improved ECM integrity supports skin firmness, elasticity, and hydration retention.

Hexapeptide-9’s mechanism also includes modulation of matrix metalloproteinases (MMPs), enzymes that degrade collagen during aging or environmental stress. By downregulating MMP-1 and MMP-9 activity, Hexapeptide-9 helps preserve collagen fibers and delays dermal thinning associated with chronological and photo-induced aging.

Another crucial mechanism involves antioxidant protection. Hexapeptide-9 reduces oxidative stress in dermal fibroblasts by enhancing the expression of superoxide dismutase (SOD) and catalase, both essential enzymes for neutralizing reactive oxygen species (ROS). This antioxidant function contributes to reduced inflammation and improved cell viability under UV radiation or pollution exposure.

In studies exploring its interaction with growth factors, Hexapeptide-9 has shown the ability to upregulate transforming growth factor beta (TGF-β) — a central regulator of collagen biosynthesis and tissue remodeling. Through this mechanism, Hexapeptide-9 promotes tissue regeneration and minimizes the visible signs of aging.

These combined molecular actions make Hexapeptide-9 an ideal research target for next-generation cosmetic peptides designed to restore youthful dermal function and improve overall skin health.

Side Effects

Hexapeptide-9 is generally regarded as a well-tolerated and non-irritating peptide in laboratory and in vitro settings. Reported adverse reactions are minimal and typically associated with formulation excipients rather than the peptide itself.

In research models, no significant cytotoxicity or mutagenic effects have been observed at standard concentrations used in cell-based assays. However, as with all research compounds, caution should be exercised to avoid contamination or exposure beyond controlled experimental environments.

When evaluating potential skin contact or topical application during formulation research, it is recommended to perform patch compatibility testing to confirm dermal tolerance.

Prolonged exposure at high concentrations may lead to mild erythema or irritation in sensitive cell cultures. These effects are reversible upon removal of the peptide from the system.

All applications should strictly adhere to research-only use, and the compound must not be tested or applied in vivo on human or animal subjects.

Keywords

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Shipping Guarantee

All shipments are handled using validated cold-chain logistics to preserve peptide integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage.

Trade Assurance

We ensure product authenticity, verified ≥99% purity, and compliance with analytical standards (HPLC, MS, and NMR). Each batch is supplied with a Certificate of Analysis (CoA). Our trade assurance policy guarantees replacement or refund for any deviation from listed specifications.

Payment Support

We provide flexible and secure global payment options to support international research transactions. Accepted payment methods include PayPal, major credit cards (Visa, MasterCard, American Express), telegraphic transfer (T/T), and cryptocurrencies (USDT, Bitcoin, Ethereum). All transactions are protected by industry-standard encryption and verified payment gateways to ensure confidentiality and fund security.

Disclaimer

All products listed are intended for laboratory research use only and not for human or veterinary use. They are not drugs, medical devices, or diagnostics and should not be administered to humans or animals. Researchers must handle all materials in accordance with institutional biosafety and chemical safety guidelines. The information provided is for scientific reference only and does not imply therapeutic efficacy, safety, or regulatory approval.