Description

Product Description

Irbesartan is a non-peptide, selective angiotensin II type 1 receptor antagonist synthesized for research applications. In laboratory models, it is utilized to block angiotensin II-mediated signaling, which allows researchers to study the physiological and molecular mechanisms underlying cardiovascular regulation, renal function, and blood pressure modulation.

Irbesartan’s high affinity for the AT1 receptor enables precise investigation of angiotensin II-dependent pathways without significant off-target activity. Experimental studies frequently explore its receptor-binding kinetics, intracellular signaling modulation, and interactions with other RAS components in both in vitro and in vivo models.

Key laboratory applications include:

• Renin-Angiotensin System (RAS) studies: Examining the regulation of angiotensin II, aldosterone, and downstream signaling cascades.

• Vascular function research: Studying endothelial cell responses, vascular smooth muscle contraction, and receptor-mediated calcium signaling.

• Renal research: Investigating angiotensin II effects on glomerular function, tubular transport, and renal cell signaling.

• Signal transduction: Exploring intracellular pathways including MAPK, PKC, and calcium-mediated signaling in response to receptor blockade.

• Combination studies: Assessing synergistic effects with other experimental compounds, receptor modulators, or bioactive molecules.

• Preclinical pharmacology: Modeling pharmacokinetics, receptor occupancy, and dose-dependent effects in experimental systems.

Irbesartan is supplied as a research-grade solid, typically in high purity (≥99%) form, suitable for in vitro assays, receptor binding studies, and preclinical animal models. Analytical verification includes HPLC, MS, and NMR to ensure reproducibility, high purity, and suitability for mechanistic research. Its solubility in DMSO, ethanol, and aqueous buffers allows flexible application across diverse experimental protocols.

Due to its selective AT1 receptor antagonism and well-characterized pharmacological profile, Irbesartan is a preferred tool for exploring the renin-angiotensin system, cardiovascular signaling, and receptor-mediated mechanisms in laboratory and preclinical studies.

Product Specifications

Mechanism of Action

Irbesartan selectively antagonizes the angiotensin II type 1 (AT1) receptor. Its mechanism of action in research is mediated primarily by preventing angiotensin II from binding to AT1 receptors in vascular, renal, and endocrine tissues.

AT1 Receptor Blockade

Irbesartan binds with high affinity to AT1 receptors, inhibiting angiotensin II-induced activation. This allows researchers to study downstream effects such as vascular smooth muscle contraction, endothelial signaling, and hormone secretion.

Renin-Angiotensin System Modulation

By preventing receptor activation, Irbesartan suppresses angiotensin II-mediated signaling pathways, enabling the study of endocrine feedback loops, aldosterone regulation, and intracellular signaling cascades in experimental models.

Intracellular Signal Transduction

Experimental studies reveal that Irbesartan modulates pathways including MAPK, PKC, and calcium-mediated signaling. This is valuable for investigating molecular mechanisms of receptor activation, vascular physiology, and cellular responses to RAS inhibition.

Research Applications

• Dose-response studies of AT1 receptor antagonism

• Vascular endothelial and smooth muscle cell signaling research

• Renal function and hormone regulation studies

• Combination experiments with other receptor modulators or bioactive compounds

• Pharmacokinetics and receptor occupancy assessments in preclinical models

Irbesartan’s high selectivity and stability make it a reliable research chemical for in vitro, ex vivo, and in vivo studies of the renin-angiotensin system and cardiovascular mechanisms.

Side Effects

In laboratory studies, Irbesartan demonstrates minimal cytotoxicity at experimental concentrations. Observed effects may include transient changes in cell signaling or receptor-mediated responses depending on assay conditions. Irbesartan is not intended for human or veterinary use outside laboratory research.

Keywords

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Shipping Guarantee

All Irbesartan shipments of Irbesartan are handled using validated cold-chain logistics to maintain compound integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage, ensuring safe delivery without degradation or contamination.

Trade Assurance

We guarantee the authenticity and high purity (≥99%) of Irbesartan. Each batch undergoes rigorous quality control, including HPLC, MS, and NMR verification. A Certificate of Analysis (CoA) is provided for every batch, confirming identity, purity, and structural integrity. Our trade assurance policy ensures replacement or refund for any deviation from listed specifications.

Payment Support

We Irbesartan provide secure and flexible payment options for international research transactions, including PayPal, major credit cards (Visa, MasterCard, American Express), telegraphic transfer (T/T), and cryptocurrencies (USDT, Bitcoin, Ethereum). All transactions are encrypted and verified, ensuring confidentiality and fund security.

Disclaimer

All Irbesartan products are intended for laboratory research use only. They are not drugs, medical devices, or diagnostics, and should not be administered to humans or animals. Researchers must comply with institutional biosafety and chemical safety guidelines. Information provided is for scientific reference only and does not imply therapeutic efficacy, safety, or regulatory approval.