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Irinotecan Hydrochloride Liposome Injection
$1.00
Irinotecan Hydrochloride Liposome Injection Du’EnYi® is China’s first domestically approved liposome-encapsulated irinotecan injection, equivalent to ONIVYDE®. Each 10mL vial contains 43mg irinotecan and is strictly for laboratory research use only—not for clinical or human application.Please consult the staff for other purposes.
Description
Irinotecan Hydrochloride Liposome Injection Specifications
| Attribute | Details |
|---|---|
| Product Name | Irinotecan Hydrochloride Liposome Injection |
| Concentration | 43mg irinotecan free base per 10mL vial (4.3mg/mL) |
| Dosage Form | IV injectable liposome formulation |
| Approval No. | China NMPA H20234150 |
| Product Code | 86902770004762 |
| Manufacturer | CSPC Ouyi Pharmaceutical Co., Ltd. |
| Intended Use | Laboratory research only—Not for clinical or veterinary use |
Irinotecan Hydrochloride Liposome Injection Mechanism of Action
This formulation encapsulates irinotecan, a topoisomerase I inhibitor, in PEGylated liposomes to prolong circulation time and increase tumor delivery. Irinotecan is converted in vivo to SN38, which interferes with DNA replication, inducing tumor cell death. ipsen.com
Research & Clinical Background
First domestic approval (Sep 2023): Du’EnYi® is approved in China for use with 5FU/LV in patients with metastatic pancreatic cancer post gemcitabine progression
Clinical context (ONIVYDE®): Liposomal irinotecan + 5FU/LV/LV improves survival in metastatic pancreatic ductal adenocarcinoma as demonstrated in NALIRIFOX and NAPOLI1 trials
Phase I PK profile (LY01610): Domestic liposomal irinotecan shows prolonged SN38 exposure and manageable toxicity in ESCC patients
Research Applications
Tumor models: Pancreatic, esophageal, colorectal cancers
Pharmacokinetic and PK/PD modeling with SN38
Liposome delivery systems and drug-loaded nanoparticle studies
Combination therapy research, e.g. 5FU, oxaliplatin, or targeted agents
Research-Use Disclaimer
This product is strictly for laboratory research and development use only. Not for human, veterinary, clinical, diagnostic, or therapeutic use.
Additional information
| Weight | 1.1 kg |
|---|---|
| Dimensions | 18 × 18 × 18 cm |
1 review for Irinotecan Hydrochloride Liposome Injection
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darkokx –
The first package was lost, the second one was received, thank you