Irinotecan Hydrochloride Liposome Injection (Du’EnYi®) – 10?mL:43?mg Vial
$1.00
Irinotecan Hydrochloride Liposome Injection Du’EnYi® is China’s first domestically approved liposome-encapsulated irinotecan injection, equivalent to ONIVYDE®. Each 10?mL vial contains 43?mg irinotecan and is strictly for laboratory research use only—not for clinical or human application.?Please consult the staff for other purposes?
描述
Irinotecan Hydrochloride Liposome Injection Specifications
| Attribute | Details |
|---|---|
| Product Name | Irinotecan Hydrochloride Liposome Injection (Du’EnYi®) |
| Concentration | 43?mg irinotecan free base per 10?mL vial (4.3?mg/mL) |
| Dosage Form | IV injectable liposome formulation |
| Approval No. | China NMPA H20234150 |
| Product Code | 86902770004762 |
| Manufacturer | CSPC Ouyi Pharmaceutical Co., Ltd. |
| Intended Use | Laboratory research only—Not for clinical or veterinary use |
Irinotecan Hydrochloride Liposome Injection Mechanism of Action
This formulation encapsulates irinotecan, a topoisomerase I inhibitor, in PEGylated liposomes to prolong circulation time and increase tumor delivery. Irinotecan is converted in vivo to SN?38, which interferes with DNA replication, inducing tumor cell death. ipsen.com
Research & Clinical Background
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First domestic approval (Sep 2023): Du’EnYi® is approved in China for use with 5?FU/LV in patients with metastatic pancreatic cancer post?gemcitabine progression
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Clinical context (ONIVYDE®): Liposomal irinotecan + 5?FU/LV/LV improves survival in metastatic pancreatic ductal adenocarcinoma as demonstrated in NALIRIFOX and NAPOLI?1 trials
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Phase I PK profile (LY01610): Domestic liposomal irinotecan shows prolonged SN?38 exposure and manageable toxicity in ESCC patients
Research Applications
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Tumor models: Pancreatic, esophageal, colorectal cancers
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Pharmacokinetic and PK/PD modeling with SN?38
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Liposome delivery systems and drug-loaded nanoparticle studies
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Combination therapy research, e.g. 5?FU, oxaliplatin, or targeted agents
?? Research-Use Disclaimer
This product is strictly for laboratory research and development use only. Not for human, veterinary, clinical, diagnostic, or therapeutic use.
其他信息
| 重量 | 1.1 公斤 |
|---|---|
| 尺寸 | 18 × 18 × 18 厘米 |
Irinotecan Hydrochloride Liposome Injection (Du’EnYi®) – 10?mL:43?mg Vial 有 1 个评价
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darkokx –
The first package was lost, the second one was received, thank you