Description

Product Description

Irinotecan Hydrochloride Liposome Solution is a high-purity, laboratory-grade liposomal formulation designed exclusively for in vitro mechanistic and molecular research. Encapsulation of irinotecan hydrochloride in liposomes stabilizes the drug, enhances solubility, and enables reproducible behavior under controlled laboratory conditions. The ready-to-use solution eliminates variability associated with lyophilized powders and supports precise mechanistic studies of drug-lipid interactions, liposomal stability, and molecular pathways.

This liposomal formulation is ideal for laboratories investigating liposome-drug binding dynamics, controlled release kinetics, and structural integrity in cell-free or synthetic systems. The solution allows researchers to simulate membrane interactions, liposomal encapsulation efficiency, and release under varying environmental conditions such as pH, ionic strength, or temperature.

Analytical techniques such as dynamic light scattering (DLS), transmission electron microscopy (TEM), high-performance liquid chromatography (HPLC), and fluorescence spectroscopy are commonly applied to study liposome size distribution, drug encapsulation, and chemical stability. These techniques enable detailed mechanistic insights and reproducible experimental results.

The solution also serves as a reference standard for method development and validation, supporting analytical assay optimization and high-throughput in vitro experiments. Its consistent liposomal properties allow comparative studies across experimental conditions, including variations in lipid composition, buffer systems, and stress environments.

Factory-controlled production ensures low-cost, bulk supply, with options for custom concentrations, batch-specific documentation, and quality verification. Each batch is confirmed for purity, liposome size, and encapsulation efficiency, guaranteeing reproducibility for mechanistic research.

By combining high purity, liposomal stability, and consistent production standards, Irinotecan Hydrochloride Liposome Solution provides a versatile tool for laboratories exploring drug-lipid interactions, controlled release mechanisms, and in vitro molecular mechanisms.

Product Specifications

Notes

Irinotecan Hydrochloride Liposome Solution is manufactured under strict factory-controlled conditions to maintain particle uniformity, high encapsulation efficiency, and chemical stability. Its solution format ensures immediate usability in in vitro mechanistic studies, including drug-lipid interactions, release kinetics, and structural integrity assays.

Bulk and wholesale orders are supported with custom concentrations, packaging options, and batch-specific documentation. Certificates of Analysis (CoA) and QC reports are provided to ensure reproducibility and support laboratory compliance.

Mechanism of Action

Irinotecan Hydrochloride Liposome Solution is a lipid-encapsulated formulation designed to facilitate controlled in vitro mechanistic studies. Encapsulation of irinotecan within liposomes enhances chemical stability, improves solubility, and allows researchers to investigate drug-lipid interactions, liposome integrity, and controlled release mechanisms under fully controlled laboratory conditions.

At the molecular level, irinotecan interacts with synthetic lipid bilayers or purified molecular constructs in vitro, providing a platform to study binding dynamics, encapsulation efficiency, and release kinetics. The liposomal carrier maintains a consistent particle size and surface property, enabling reproducible mechanistic observations across multiple experiments.

Researchers can monitor liposome stability, drug release profiles, and membrane interactions using analytical techniques such as dynamic light scattering (DLS), transmission electron microscopy (TEM), fluorescence spectroscopy, and HPLC. These measurements provide insights into liposome-drug behavior, nanoscale stability, and mechanistic pathways in controlled experimental setups.

The liposomal formulation also allows systematic investigation of environmental factors, such as pH, ionic strength, or temperature, which influence liposome integrity and drug release. Adjusting these parameters enables the study of mechanistic pathways and drug-lipid dynamics at a molecular level.

Irinotecan Hydrochloride Liposome Solution can also serve as a reference standard for method development, supporting assay optimization, validation, and high-throughput in vitro studies. Its combination of chemical stability, high encapsulation efficiency, and reproducible liposome characteristics ensures reliable mechanistic data for laboratories.

Overall, this solution provides a robust platform for investigating liposomal drug behavior, controlled release mechanisms, and molecular interactions in fully controlled in vitro research settings.

Applications

Irinotecan Hydrochloride Liposome Solution is widely used in in vitro mechanistic and molecular research due to its high-purity, stable liposomal formulation. Its ready-to-use solution ensures reproducibility and precision in experiments studying drug-lipid interactions, liposome integrity, and controlled release mechanisms.

1. Liposome-Membrane Interaction Studies

This solution allows detailed examination of lipid bilayer dynamics, drug encapsulation, and membrane interactions in synthetic systems or purified protein constructs. Researchers can investigate liposome stability, membrane penetration, and binding dynamics in controlled laboratory settings.

2. Controlled Drug Release Studies

The liposomal formulation enables evaluation of drug release kinetics under varying environmental conditions, including pH, ionic strength, and temperature. This supports mechanistic studies of controlled release and liposomal drug behavior in vitro.

3. Structural and Conformational Analysis

Irinotecan Liposome Solution is ideal for assessing nanoparticle size, morphology, and structural stability using techniques such as DLS, TEM, and fluorescence spectroscopy. These studies help characterize liposome integrity and encapsulation efficiency.

4. Analytical Method Development

It serves as a reference standard for validating analytical assays, including chromatography, fluorescence detection, and high-throughput screening methods, ensuring reproducibility and accuracy.

5. High-Throughput Mechanistic Assays

Compatible with automated in vitro platforms, the solution supports parallel testing of multiple experimental conditions, including lipid composition, drug concentration, and buffer variations, enhancing experimental throughput.

6. Integration with Computational Studies

Experimental data obtained with the solution can be integrated with molecular modeling, docking simulations, and predictive algorithms to refine mechanistic hypotheses and validate in vitro findings.

Overall, Irinotecan Hydrochloride Liposome Solution provides a versatile platform for laboratories performing mechanistic, structural, and kinetic studies of liposomal drug behavior under controlled in vitro conditions.

Research Models

Irinotecan Hydrochloride Liposome Solution is designed for controlled in vitro research models, enabling detailed studies of liposomal drug behavior, release kinetics, and drug-lipid interactions at a molecular level. Its stable, high-purity formulation ensures reproducible results and supports mechanistic and structural investigations.

1. Synthetic Membrane Systems

The solution is suitable for liposome-membrane interaction studies using synthetic lipid bilayers or supported membranes. These models allow laboratories to study drug encapsulation, bilayer insertion, and molecular dynamics without the complexity of cellular systems.

2. Controlled Release and Kinetics Models

Time-course experiments can assess drug release rates, environmental sensitivity, and liposome stability under controlled conditions. These models provide precise data on mechanistic pathways of drug release and liposomal behavior.

3. Structural Stability Models

Researchers can evaluate nanoparticle size distribution, morphology, and liposome integrity using techniques such as dynamic light scattering (DLS), transmission electron microscopy (TEM), and fluorescence spectroscopy. This supports reproducibility and characterization of liposome stability.

4. Analytical Validation Models

The solution can be used as a reference standard for validating analytical assays, including chromatography, fluorescence detection, and high-throughput screening. This ensures that experimental results are reliable and reproducible.

5. Computational Integration Models

Experimental data from in vitro studies can be combined with computational simulations, molecular docking, and predictive modeling to explore liposome-drug interactions and release mechanisms. This supports mechanistic hypothesis development and validation.

Overall, these research models provide a robust platform for laboratories to study Irinotecan Hydrochloride Liposome Solution in mechanistic, structural, and kinetic contexts, ensuring reproducible and meaningful in vitro results for molecular mechanism research.

Experimental Design Considerations

Designing experiments with Irinotecan Hydrochloride Liposome Solution requires careful planning to ensure reproducible, accurate, and mechanistically relevant results. The liposomal formulation is sensitive to environmental conditions, so proper experimental setup is critical.

1. Environmental Control

Maintain precise control of temperature, pH, ionic strength, and buffer composition. These factors influence liposome stability, drug encapsulation, and release kinetics, which are essential for reliable mechanistic studies.

2. Liposome Concentration and Integrity

Optimize liposome concentration according to assay requirements. Confirm particle size, polydispersity, and encapsulation efficiency using analytical techniques such as DLS, TEM, or HPLC before use to ensure consistency.

3. Time-Course and Kinetic Studies

Design experiments to monitor drug release rates, liposome-membrane interactions, and structural stability over time. Sampling at defined intervals allows detailed analysis of kinetic profiles and mechanistic pathways.

4. Analytical Method Integration

Select appropriate analytical techniques, including fluorescence spectroscopy, HPLC, and nanoparticle tracking analysis, to detect structural changes, release kinetics, and molecular interactions. Integrating analysis into the experimental plan ensures measurable outcomes.

5. Replication and Statistical Planning

Include adequate replicates and controls to validate observations. Document lot numbers, storage conditions, and handling procedures to support reproducibility across experiments and laboratories.

6. Computational and Predictive Modeling

Combine experimental results with in silico simulations, docking studies, and predictive models to validate mechanistic hypotheses and predict liposome behavior under varied conditions.

By following these design considerations, laboratories can perform high-precision, reproducible in vitro experiments with Irinotecan Hydrochloride Liposome Solution, providing reliable insights into liposomal drug behavior, release kinetics, and molecular interactions.

Laboratory Safety & Handling Guidelines

Irinotecan Hydrochloride Liposome Solution is a high-purity laboratory reagent intended exclusively for in vitro mechanistic and molecular research. Proper handling is essential to maintain liposome integrity, chemical stability, and laboratory safety.

1. Personal Protective Equipment (PPE)

Always wear gloves, lab coat, and eye protection when handling the solution. Conduct all work in a controlled laboratory environment to prevent contamination and ensure safe handling.

2. Handling and Preparation

Use dedicated laboratory consumables to avoid cross-contamination. Pipette carefully to maintain liposome integrity and prevent aggregation or mechanical disruption.

3. Storage Conditions

Store the solution at 2–8°C in sealed, light-protected containers. Avoid repeated freeze-thaw cycles, high temperatures, or direct sunlight, which may compromise liposome stability.

4. Spill and Decontamination Procedures

In case of spills, contain immediately with laboratory-approved absorbents. Clean surfaces using appropriate buffers or decontamination solutions, and dispose of contaminated materials according to institutional chemical waste protocols.

5. Documentation and Traceability

Maintain detailed records of lot numbers, storage conditions, and experimental usage. Proper documentation ensures reproducibility and supports troubleshooting across experiments.

6. Laboratory Equipment

Use chemically compatible glassware, pipettes, and microplates dedicated to liposomal research. Avoid materials that may adsorb or destabilize liposomes.

Following these guidelines ensures safe handling, reproducible results, and reliable mechanistic insights in laboratory-based in vitro studies.

Integration with Multi-Omic & Computational Studies

Irinotecan Hydrochloride Liposome Solution can be integrated into multi-omic workflows and computational modeling to provide detailed insights into liposomal drug interactions, release mechanisms, and molecular pathways in vitro. Its stable, high-purity formulation allows reproducible data collection suitable for proteomic, structural, and computational analysis.

1. Proteomic and Structural Integration

In vitro studies with the solution can generate data on liposome-protein interactions, encapsulation efficiency, and structural dynamics. Proteomic and structural analysis methods, such as mass spectrometry and TEM, can map binding events, validate mechanistic hypotheses, and reconstruct molecular pathways.

2. Computational Modeling Applications

Stable liposome behavior and controlled drug release profiles enable integration with molecular docking, reaction pathway simulations, and predictive structural models. Comparing computational predictions with experimental data refines mechanistic models and validates simulation accuracy.

3. Multi-Omic Correlation

Experimental in vitro data can be correlated with transcriptomic, proteomic, or metabolomic datasets from controlled systems to identify mechanistic relationships. This supports reconstruction of molecular pathways and predictive modeling of liposome-drug interactions.

4. Analytical Method Validation

Irinotecan Liposome Solution serves as a reference standard for validating analytical techniques, including chromatography, fluorescence assays, and nanoparticle characterization. Integration with computational models enhances interpretation and reproducibility.

Overall, the solution enables laboratories to combine mechanistic in vitro data with multi-omic and computational analyses, providing a robust framework to study liposomal drug behavior, release mechanisms, and molecular interactions.

Things to Note

1. Laboratory Use Only
   Irinotecan Hydrochloride Liposome Solution is intended exclusively for in vitro mechanistic, structural, and biochemical research. It is not suitable for human or veterinary use, clinical applications, or diagnostic purposes.

2. Handling and Safety
   Always use appropriate PPE, including gloves, lab coat, and eye protection. Handle in a controlled laboratory environment to maintain liposome integrity and prevent contamination.

3. Storage and Stability
   Store in sealed, light-protected containers at 2–8°C. Avoid repeated freeze-thaw cycles, heat, or light exposure, which can compromise liposome stability and encapsulation efficiency.

4. Analytical Verification
   Before experiments, confirm liposome size distribution, encapsulation efficiency, and chemical integrity using techniques such as DLS, TEM, or HPLC to ensure reproducibility.

5. Waste Management
   Dispose of residual solution and contaminated materials according to institutional chemical waste protocols. Decontaminate surfaces and equipment after use.

6. Experimental Considerations
   Design experiments considering environmental sensitivity, liposome stability, and controlled release kinetics to ensure reliable and mechanistically meaningful results.

Following these notes ensures safe handling, reproducible data, and reliable mechanistic insights in laboratory-based in vitro studies.

Keywords

Irinotecan Hydrochloride Liposome Solution, high-purity liposomal irinotecan, laboratory-grade liposome solution, in vitro mechanistic studies, liposome-drug interaction reagent, nanoparticle drug delivery research, controlled release kinetics, liposome stability analysis, biochemical pathway modeling, molecular mechanism research, high-throughput in vitro screening, structural dynamics reagent, proteomic and computational integration, factory-manufactured research reagent, bulk and wholesale laboratory supply, mechanistic pathway analysis reagent, controlled laboratory workflow reagent, high-purity solution for in vitro assays, analytical method validation liposome, Tumor (compound) Research, multi-omic integration reagent.

Shipping Guarantee

Factory-manufactured Irinotecan Hydrochloride Liposome Solution is packaged to maintain liposome integrity, chemical stability, and high purity during transport. Bulk and wholesale orders are supported with secure shipment and tracking, ensuring the solution arrives in optimal condition for in vitro mechanistic and molecular studies. Shipments are handled to minimize exposure to heat, light, and contamination.

Trade Assurance

• Low-price wholesale supply directly from the factory.

• Bulk order customization available, including solution concentration and packaging options.

• Guaranteed high-purity liposomal solution for in vitro drug-lipid interaction and mechanistic studies.

• Factory-direct supply ensures consistent quality and reproducibility across multiple batches.

Payment Support

Multiple secure payment options are available to facilitate global laboratory procurement:

• PayPal

• Cryptocurrency

• Bank Transfer (TT)

• Credit Card

• Verified online payment systems

These options provide flexibility and security for bulk or wholesale orders, ensuring laboratories can obtain the product reliably and efficiently.

Disclaimer

Irinotecan Hydrochloride Liposome Solution is intended exclusively for laboratory research use. It is not approved for human or veterinary applications, diagnostic purposes, or therapeutic interventions. All experiments must be conducted in controlled in vitro, molecular, or mechanistic studies. Users must follow institutional safety protocols and chemical handling procedures. The product should never be administered to living organisms or used outside of research settings.

References

1. Xu C. et al. “A Stable Irinotecan Liposome with Enhanced Antitumor Activity in a Range of Tumor Models.” Cancer Research Communications, 2023. Describes a stable irinotecan liposome (average diameter ~110–120 nm, encapsulation >95%) and its physicochemical stability. (PubMed)

2. Garbey M., et al. “Liposomal irinotecan: formulation development and therapeutic assessment in murine xenograft models of colorectal cancer.” Journal of Controlled Release, 2004; 100(1): 87–101. Demonstrates extended distribution and enhanced stability of liposome-encapsulated irinotecan compared to free drug. (PubMed)

3. Chan HS., et al. “Formulation and in vitro characterization of thermosensitive liposomes for the delivery of irinotecan.” Journal of Liposome Research, 2014; 24(4): 307–319. Provides in vitro data on encapsulation, release kinetics, and stability of thermosensitive irinotecan liposomes. (PubMed)

4. Vaidya KS., et al. “Liposomal Irinotecan Accumulates in Metastatic Lesions, Crosses the Blood-Tumor Barrier, and Prolongs Survival in an Experimental Model of Brain Metastases of Triple Negative Breast Cancer.” Cancer Research, 2018; 78(3): 664–676. Provides data on liposome size (~100–110 nm), stability, and drug distribution, useful for mechanistic studies. (PMC)

5. Liu H., et al. “Preparation of irinotecan hydrochloride loaded PEGylated liposomes using a novel method supercritical fluid and condition optimized by Box–Behnken design.” Nanoscale Research Letters, 2024; 19:40. Details PEGylated liposome preparation, encapsulation efficiency, particle size, and in vitro release characteristics. (PubMed)