描述
Product Specifications
Attribute | Details |
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Product Name | Ketorolac Tromethamine Injection (HaiXin®) |
Generic Name | Ketorolac Tromethamine |
CAS Number | 74103?06?3 zh.wikipedia.org+1yao.dxy.cn+1 |
Molecular Formula | C??H??NO? |
Molecular Weight | ~255.3?g/mol (ketorolac tromethamine salt) |
Dosage Form | Sterile aqueous solution for IV/IM injection |
Strength | 30?mg / 1?mL vial |
Pack Size | 10 vials per box |
Approval Number | China NMPA H20223467 |
Product Code | 86981812000030 |
Manufacturer | Nanjing Hairong Pharmaceutical Co., Ltd. |
Barcode | 6973204570058 |
Storage Conditions | Store at 2–25?°C; protect from light and moisture |
Intended Use | Laboratory research only |
Mechanism of Action
Ketorolac is a non-selective cyclooxygenase (COX?1/COX?2) inhibitor that reduces prostaglandin and thromboxane synthesis. It delivers rapid analgesia and anti-inflammatory effects comparable to opioid strength .
Research Applications & Pharmacology
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Acute Pain Models: Highly effective in preclinical studies of moderate to severe pain (e.g., post-operative, trauma, cancer pain).
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Analgesia without Opioids: Recommended as a standalone or adjuvant to lessen opioid dosage and associated risks .
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Administration Routes: Suitable for IV and IM injection; rapid onset (analgesia within 30 minutes; peak effect in 1–2?h; duration ~4–6?h) .
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Pharmacokinetics: Bioavailability ~100% via injection, half?life 3.5–9?h depending on age, primarily excreted renally (~91%) .
Safety Profile & Handling
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Adverse Effects: Common GI symptoms (nausea, abdominal pain), dizziness, injection-site discomfort; serious risks include GI bleeding, renal impairment, cardiovascular events, hypersensitivity .
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Handling Precautions: Use sterile technique; inspect vials for particulates; avoid mixing with certain opioids/antiemetics to prevent precipitation .
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Contraindications: Not suitable for active ulcers, bleeding disorders, renal/liver impairment, late-stage pregnancy, or combined use with other NSAIDs .
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Storage: Seal at ?30?°C, shield from light; stable for 24 months ypsm.yzsbh.com.
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