Description

Lacosamide Injection Product Description

Lacosamide is a functionalized amino acid compound that selectively enhances slow inactivation of voltage-gated sodium channels, thereby stabilizing hyperexcitable neuronal membranes. This injectable form allows for controlled pharmacokinetic studies in vivo, particularly in acute seizure models or prolonged infusion paradigms for CNS pharmacology.

Lacosamide’s safety, efficacy, and molecular targeting make it a valuable compound for research in focal epilepsy, neuropathic pain, and neuroplasticity modulation.

Lacosamide Injection Product Specifications

Mechanism of Action

Lacosamide enhances the slow inactivation of voltage-gated sodium channels without affecting fast inactivation, resulting in reduced repetitive neuronal firing. This makes it distinct from older antiepileptics and valuable for comparative pharmacology in CNS hyperexcitability models.

Research Applications

• Seizure & Epilepsy Models: Effective in kindling, maximal electroshock, and PTZ-induced seizure models.

• Neuropathic Pain Research: Useful in studies of diabetic neuropathy and spinal pain transmission pathways.

• Neuroprotection Studies: Evaluated for preventing neurodegeneration following repetitive seizure events.

• PK/PD Studies: Suitable for infusion rate, clearance, and half-life investigation in CNS targeting agents.

Safety & Handling

• Common effects in models: Sedation, altered locomotor activity.

• Handling: Use PPE. Reconstitute under aseptic conditions.

• Storage: Lyophilized powder should be stored below 25?°C in a moisture-free, light-resistant environment.

• Shelf-life: Stable for up to 24 months under recommended conditions.

Research-Only Disclaimer

This product is intended strictly for laboratory research use only. It is not for human consumption, diagnosis, or therapy. Any misuse is strictly prohibited. Follow institutional safety protocols and local regulatory guidance.