Description

Leflunomide is a disease-modifying compound primarily used in autoimmune and inflammation-related research. It acts by inhibiting pyrimidine synthesis, thus reducing T-cell proliferation and cytokine production.

The Lile Ning formulation provides 10mg of leflunomide per tablet, ideal for in vitro and in vivo exploration of its effects on immune signaling pathways, joint degradation, and inflammatory cascades. Each bottle contains 30 tablets.

Approved under H20223488 with product code 86904859000153, this product is manufactured by Xiamen Lizhuo Pharmaceutical Co., Ltd. (Barcode: 6974026710318).

?? For laboratory research use only. Not approved for human or veterinary administration.

Leflunomide Tablets Product Specifications

Leflunomide Tablets Mechanism & Research Applications

Leflunomide inhibits dihydroorotate dehydrogenase (DHODH), an enzyme necessary for pyrimidine synthesis in proliferating lymphocytes. This leads to suppression of T-cell activation and inflammatory mediator release.

Research applications include:

• Autoimmune disease modeling (e.g., rheumatoid arthritis)

• T-cell proliferation and cytokine studies

• Inflammation and joint degradation assays

• Combination immunotherapy preclinical evaluations

• Signal transduction inhibition models

Leflunomide Tablets Side Effects (Observed in Research Models)

• Hepatic enzyme elevation in chronic dosing

• Decreased white blood cell counts in high-dose models

• Gastrointestinal effects: diarrhea, nausea

• Teratogenic effects in reproduction studies

• Weight loss and fatigue in long-term trials

Appropriate laboratory controls and dosing precision are strongly advised.

Safety & Handling

• Use Restriction: For scientific research only; not for therapeutic or veterinary use

• PPE Required: Gloves, protective eyewear, lab coat

• Storage: Keep sealed, dry, below 25°C

• Disposal: Follow chemical waste regulations and biosafety rules

Core Keywords

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Research Use Disclaimer

This product is strictly intended for laboratory research use only. Not approved for diagnostic, clinical, or therapeutic applications in humans or animals. Handle in accordance with institutional safety guidelines and chemical handling protocols.