Description

Product Description

Manganese Tripeptide-1 is a synthetic bioactive peptide that incorporates the essential trace element manganese, playing a pivotal role in cellular antioxidant defense and tissue regeneration. This tripeptide is recognized for its potent skin-protective capabilities, acting at the molecular level to counter oxidative damage, stimulate fibroblast activity, and maintain the integrity of the extracellular matrix. Its combined metal-peptide complex structure makes it a valuable component in research on skin aging, photo-damage, and pigmentation disorders.

1. Structural Characteristics

Manganese Tripeptide-1 consists of a tripeptide backbone conjugated to a manganese ion, forming a stable coordination complex. The peptide sequence enhances metal ion delivery to skin cells, providing localized antioxidant protection and aiding enzymatic processes involved in tissue recovery. This hybrid structure not only stabilizes the peptide but also boosts its biological availability and effectiveness.

2. Biological Activity and Mechanistic Overview

The bioactivity of Manganese Tripeptide-1 arises from its dual functionality — serving as both an antioxidant catalyst and a signaling modulator. Manganese acts as a cofactor in the activation of superoxide dismutase (MnSOD), an enzyme crucial in neutralizing reactive oxygen species (ROS). The tripeptide component enhances cellular uptake and facilitates repair mechanisms within the dermis.

Research indicates that Manganese Tripeptide-1 reduces the oxidative stress burden within skin fibroblasts, thereby preventing lipid peroxidation and DNA damage induced by UV exposure. It also supports the synthesis of structural proteins such as collagen and elastin, which are fundamental for maintaining dermal firmness and elasticity. As oxidative stress is one of the primary contributors to skin aging, the compound’s capacity to mitigate free radicals translates into visible improvements in texture, tone, and resilience in experimental models.

3. Applications in Cosmetic Science and Dermatological Research

Manganese Tripeptide-1 is commonly studied for its applications in anti-aging, anti-inflammatory, and pigmentation research. It is often incorporated into topical formulations for:

• Reducing visible wrinkles and fine lines through collagen stimulation.

• Supporting cellular antioxidant defenses against environmental aggressors.

• Improving skin brightness by modulating melanogenesis pathways.

• Enhancing wound healing and barrier recovery following oxidative damage.

Additionally, Manganese Tripeptide-1 has been observed to complement other cosmetic peptides such as Palmitoyl Tripeptide-1 and Acetyl Hexapeptide-8, creating synergistic effects in anti-aging formulations.

4. Role in Skin Brightening and Melanogenesis Modulation

Melanogenesis is a complex biochemical process governed by tyrosinase activity and oxidative reactions. Manganese Tripeptide-1 has been found to indirectly reduce melanin synthesis by decreasing oxidative intermediates that promote melanin polymerization. Through its antioxidant role, it modulates tyrosinase-related signaling and supports a more balanced pigmentation process, leading to brighter and more uniform skin tone in laboratory models.

5. Antioxidant and Cellular Protection Pathways

The peptide’s unique manganese coordination complex enables it to mimic the function of metalloenzymes that detoxify reactive oxygen species. This protective mechanism contributes to the stabilization of mitochondrial function and DNA integrity. In research models, Manganese Tripeptide-1 exposure significantly reduced oxidative biomarkers while enhancing the expression of endogenous antioxidant proteins such as catalase and glutathione peroxidase.

6. Integration into Cosmetic Research and Product Formulation

Due to its excellent safety profile and molecular stability, Manganese Tripeptide-1 is often investigated as an advanced active ingredient for serums, creams, and restorative treatments targeting mature, fatigued, or UV-damaged skin. Its bioavailability allows for effective penetration into the epidermal layers, where it activates cellular renewal pathways. Cosmetic researchers utilize this peptide to explore skin rejuvenation and antioxidant restoration at a molecular level.

Overall, Manganese Tripeptide-1 represents a next-generation peptide ingredient for laboratory and cosmetic R&D, offering an ideal combination of antioxidant protection, wrinkle reduction, and melanin control.

Product Specifications

Mechanism of Action

The mechanism of Manganese Tripeptide-1 primarily revolves around its antioxidant and repair-promoting properties at the cellular level.

1. Antioxidant Defense Activation:
   The peptide-metal complex enhances the activation of manganese-dependent superoxide dismutase (MnSOD), which neutralizes superoxide radicals into less harmful molecules. This prevents lipid peroxidation and cellular oxidative damage that contribute to premature skin aging.

2. DNA and Collagen Protection:
   By reducing oxidative DNA fragmentation and cross-linking of collagen fibers, the peptide supports dermal structural integrity. It also encourages fibroblast proliferation, facilitating natural collagen renewal.

3. Melanin Regulation:
   Through indirect inhibition of tyrosinase activation and reduction of ROS-mediated signaling, the peptide helps maintain balanced melanogenesis. This results in more even pigmentation and a reduction of dark spots in laboratory assessments.

4. Wound Healing Enhancement:
   Studies show manganese peptides can upregulate the expression of metalloproteinases and growth factors, which aid tissue remodeling and faster wound closure. This makes it an important research compound in regenerative and restorative skin biology.

   

Side Effects

In research settings, Manganese Tripeptide-1 demonstrates excellent biocompatibility and low cytotoxicity at experimental concentrations. No irritation, sensitization, or pro-oxidant effects have been reported under standard laboratory conditions.
Nevertheless, as with all research compounds, usage should remain within approved in vitro or ex vivo cosmetic testing protocols. It is not intended for clinical or therapeutic applications in humans or animals.

Keywords

Manganese Tripeptide-1, CAS 611182-15-1, cosmetic peptide supplier, antioxidant peptide, anti-wrinkle peptide, skin brightening research peptide, high-purity cosmetic peptides, peptide wholesale China, OEM & bulk peptide production, cosmetic raw material manufacturer, China peptide manufacturer, peptide factory, research-grade peptide.

Shipping Guarantee

All Manganese Tripeptide-1 shipments are handled using validated cold-chain logistics to preserve peptide integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage.

Trade Assurance

We Manganese Tripeptide-1 ensure product authenticity, verified ≥99% purity, and compliance with analytical standards (HPLC, MS, and NMR). Each batch is supplied with a Certificate of Analysis (CoA). Our trade assurance policy guarantees replacement or refund for any deviation from listed specifications.

Payment Support

We Manganese Tripeptide-1 provide flexible and secure global payment options to support international research transactions. Accepted payment methods include PayPal, major credit cards (Visa, MasterCard, American Express), telegraphic transfer (T/T), and cryptocurrencies (USDT, Bitcoin, Ethereum). All transactions are protected by industry-standard encryption and verified payment gateways to ensure confidentiality and fund security.

Disclaimer

All Manganese Tripeptide-1 products listed are intended for laboratory research use only and not for human or veterinary use. They are not drugs, medical devices, or diagnostics and should not be administered to humans or animals. Researchers must handle all materials in accordance with institutional biosafety and chemical safety guidelines. The information provided is for scientific reference only and does not imply therapeutic efficacy, safety, or regulatory approval.