Marlumotide (CAS 952720-86-4)

描述

Product Description

Marlumotide (CAS 952720-86-4) is a synthetic immunological peptide developed as an active immunization agent with antineoplastic properties. Its design allows researchers to explore both immune system activation and tumor growth inhibition in preclinical models.

Background and Research Importance

The immune system plays a critical role in identifying and eliminating cancer cells. Marlumotide acts as an immunostimulatory agent, enhancing antigen presentation, activating cytotoxic T cells, and promoting cytokine secretion. This makes it an invaluable research tool for:

• Studying cancer immunotherapy mechanisms.

• Exploring peptide-based vaccine development.

• Investigating immune modulation in oncology.

Preclinical studies demonstrate that Marlumotide can induce specific antitumor immune responses while maintaining a favorable safety profile in laboratory models. It is particularly suitable for studies involving tumor-bearing rodents, humanized immune system models, and in vitro immune assays.

Chemical Properties and Structure

• Compound Class: Synthetic immunological peptide

• Target: Immune system activation for antitumor responses

• Mechanism: Stimulates T cell and antigen-presenting cell activity

• Activity: Immunostimulatory, antineoplastic

• Stability: Lyophilized peptide ensures extended shelf life

• Applications: Tumor immunology, immune response studies, preclinical cancer research

Marlumotide’s synthetic design allows high reproducibility and structural integrity, providing consistent biological activity across experimental batches.

Product Specifications

Marlumotide’s specifications ensure reproducibility, high purity, and reliable immunostimulatory activity, making it suitable for detailed mechanistic and preclinical studies.

Mechanism of Action & Research Applications

Mechanism of Action

Marlumotide exerts its immunological and antineoplastic effects through:

1. Activation of Antigen-Presenting Cells (APCs): Stimulates dendritic cells and macrophages to enhance antigen presentation.

2. Cytotoxic T Cell Activation: Promotes CD8+ T cell proliferation and cytotoxic function against tumor cells.

3. Cytokine Modulation: Induces secretion of interferons, interleukins, and other immunostimulatory cytokines.

4. Tumor Growth Inhibition: Enhances immune-mediated tumor cell apoptosis and reduces tumor progression in preclinical models.

This multi-faceted mechanism allows researchers to study both adaptive immune responses and direct antitumor effects in vitro and in vivo.

Research Applications

1. Cancer Immunotherapy Research
Used to study immune-based approaches to inhibit tumor growth and explore novel peptide vaccine strategies.

2. Immune Activation Studies
Facilitates investigation of T cell, NK cell, and APC function under controlled laboratory conditions.

3. Cytokine Response Analysis
Enables researchers to profile immune signaling pathways and cytokine networks in response to peptide stimulation.

4. Preclinical Tumor Models
Marlumotide is suitable for rodent tumor models, humanized immune system mice, and ex vivo tumor-immune co-culture assays.

5. Combination Therapy Research
Supports studies combining immunostimulatory peptides with chemotherapy, checkpoint inhibitors, or other antitumor agents.

6. Translational Research
Data generated with Marlumotide informs the development of peptide-based immunotherapies and clinical trial designs.

7. Mechanistic Immunology
Allows exploration of antigen presentation, immune cell trafficking, T cell receptor signaling, and immune tolerance.

8. In Vitro Immune Profiling
Used in cellular assays to quantify T cell proliferation, cytokine secretion, and immune cell activation markers.

9. Comparative Immunotherapy Studies
Supports evaluation against other immunostimulatory agents to optimize potency and specificity.

10. Therapeutic Peptide Development
Marlumotide serves as a model compound for engineering next-generation immunomodulatory peptides.

The versatility of Marlumotide in tumor immunology and immune modulation makes it a critical tool for research laboratories worldwide.

Side Effects (For Reference in Research Models)

Experimental observations in preclinical studies include:

• Cytokine Release: Dose-dependent stimulation may induce transient cytokine spikes in vitro.

• Immune Cell Stress: High concentrations can lead to temporary stress in certain immune cell populations.

• Species-Specific Responses: Effects may vary across rodents, humanized mice, or ex vivo models.

• Peptide Stability Considerations: Repeated freeze-thaw cycles can reduce activity; proper storage is required.

• Tumor Model Variability: Response rates may differ depending on tumor type, stage, and immune status.

• Combination Effects: Interactions with other agents may alter immune activation or antitumor efficacy.

These observations are strictly for laboratory research reference. Marlumotide is not for human or veterinary use.

Disclaimer

For laboratory research use only. Not for human or veterinary use.

Keywords

• Marlumotide CAS 952720-86-4

• Antineoplastic immunological peptide

• Active immunization research peptide

• GMP-grade Marlumotide

• Cancer immunotherapy research peptide

• Tumor immunology peptide

• Laboratory immune response modulator

• Synthetic immunostimulatory peptide

• Peptide vaccine research compound

• Research use only immunological agent