描述
Mecobalamin, also known as methylcobalamin, is the coenzyme form of Vitamin B12 with high bioavailability and neurological significance. Compared to cyanocobalamin, mecobalamin crosses the blood-brain barrier more effectively, making it a valuable agent for studying neuropathies, nerve repair, and central nervous system disorders.
This formulation provides 0.5 mg per tablet, commonly used in research related to diabetic neuropathy, spinal cord regeneration, and vitamin B12 deficiency models. The product is manufactured by Chinsin Pharmaceutical Co., Ltd. and is approved under NMPA registration H20051425.
Product Specifications
Parameter | Description |
---|---|
Product Name | Mecobalamin Tablets |
Generic Name | Methylcobalamin (Coenzyme Vitamin B12) |
CAS Number | 13422-55-4 |
Molecular Formula | C63H91CoN13O14P |
Molecular Weight | ~1344.38 g/mol |
Strength | 0.5 mg per tablet |
Pack Size | 10 tablets × 3 blisters = 30 tablets |
Formulation | Oral tablets |
Approval Number | NMPA H20051425 (China) |
Pharmacopoeia | Complies with Chinese Pharmacopoeia |
Manufacturer | Chinsin Pharmaceutical Co., Ltd. |
Storage | Store in a cool, dry place below 25?°C |
Intended Use | For research use only |
Mechanism of Action
Mecobalamin functions as a coenzyme in the conversion of homocysteine to methionine, promoting myelin sheath formation, axon regeneration, and DNA synthesis. Its enhanced cellular uptake and neurotropic activity make it ideal for laboratory models of nerve injury, diabetic neuropathy, and B12-related cognitive studies.
Research Applications
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Peripheral Neuropathy Models: Improves nerve conduction and sensory-motor recovery.
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Diabetic Neuropathy Research: Demonstrates reduction in hyperalgesia and numbness in preclinical models.
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Spinal Cord Injury Studies: Supports regeneration and repair of damaged neurons.
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Cognitive Function & Memory: Investigated for effects on B12-deficiency-related cognitive decline.
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B12 Metabolism Studies: Used in comparative bioavailability research of different B12 forms.
Safety & Handling
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Common Lab Observations: Mild GI disturbance in rodent studies; rare hypersensitivity
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Handling: Use gloves and avoid contamination; standard lab hygiene applies.
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Storage: Keep sealed, dry, and protected from light. Avoid freezing.
Research Use Disclaimer
This product is for laboratory research use only. It is not intended for clinical, diagnostic, or therapeutic use in humans or animals. Handle in accordance with institutional biosafety regulations.
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