Description

Product Description

Myelopeptide-2 (MP-2) is a bioactive peptide isolated from the supernatant of porcine bone marrow cell cultures. It belongs to the myelopeptide family—a group of small peptides known for their immunoregulatory, hematopoietic, and homeostatic functions.

Myelopeptide-2 has demonstrated the ability to restore the mitogenic reactivity of human T lymphocytes that have been suppressed by HL-60 leukemia cells or measles virus infection. This property positions Myelopeptide-2 as an important molecule in immune restoration research.

At the molecular level, Myelopeptide-2 enhances interleukin-2 (IL-2) synthesis and IL-2 receptor (IL-2R) expression, both of which are critical for T-cell activation and proliferation. Through this mechanism, it reverses immune suppression, helping the body regain normal immune responsiveness in states of cancer or viral infection.

Biological Background

The immune system’s efficiency often diminishes under pathological conditions such as cancer, chronic viral infection, or immunodeficiency syndromes. In such cases, T-cell dysfunction and cytokine dysregulation contribute to immune escape and disease progression.

Myelopeptide-2 acts as a natural immunocorrective peptide, capable of restoring cytokine balance and promoting lymphocyte function. It contributes to:

• Reactivation of T-cell mitogenic response

• Recovery of IL-2 signaling pathways

• Enhancement of cell-mediated immunity

• Regulation of immune homeostasis

Myelopeptide-2’s dual action—restoring suppressed immunity while preventing excessive immune activation—makes it a promising candidate for therapeutic exploration in oncology, virology, and autoimmune disease modulation.

Experimental Applications

Myelopeptide-2 has broad applications across multiple areas of biomedical research:

1. Tumor Immunology

   • Reactivates T-cell proliferation in tumor-suppressed environments

   • Restores IL-2-driven cytotoxic T-cell activity

   • Potential adjuvant in immunotherapy models

2. Viral Infection Studies

   • Counteracts viral-induced immune suppression (e.g., measles virus)

   • Enhances immune cell responsiveness against viral antigens

3. Autoimmune and Immunodeficiency Models

   • Restores immune equilibrium in dysregulated conditions

   • Useful in studying cytokine feedback mechanisms

4. Hematopoietic Research

   • Supports recovery of bone marrow–derived lymphocytes

   • May play a role in myelopoiesis modulation

Product Specifications

Synonyms

• MP-2

• Bone marrow immunopeptide-2

• Immunoregulatory peptide from porcine bone marrow

Mechanism of Action

Myelopeptide-2 exerts its biological activity primarily through reconstitution of the IL-2/IL-2R signaling axis, which is central to T-cell activation and immune function.

1. Restoration of T-Lymphocyte Mitogenic Activity

In immunosuppressive conditions caused by leukemia cells or viral infection, T-cell mitogenic responses to antigens or mitogens (e.g., phytohemagglutinin) are significantly reduced. Myelopeptide-2 reestablishes this proliferative capacity, allowing T-cells to regain normal responsiveness.

2. Enhancement of IL-2 and IL-2R Expression

Myelopeptide-2 upregulates interleukin-2 synthesis and IL-2 receptor expression, promoting T-cell activation, differentiation, and proliferation. This restoration of IL-2 signaling is crucial for effective immune recovery.

3. Normalization of Immune Homeostasis

The peptide balances cytokine production and suppresses abnormal immune responses. It modulates both helper T-cell (Th1/Th2) cytokine balance and regulatory T-cell activity, preventing excessive inflammation while sustaining immune vigilance.

4. Antitumor and Antiviral Potential

By reversing immune suppression and reactivating cytotoxic T-cells, Myelopeptide-2 enhances antitumor and antiviral defense mechanisms. It contributes to the host’s ability to detect and destroy aberrant or infected cells.

Side Effects

In preclinical research, Myelopeptide-2 demonstrates low toxicity and high biocompatibility. No cytotoxic or mutagenic effects have been reported. However, it should be used under controlled experimental conditions:

• Avoid excessive concentrations (>100 µM), which may alter cytokine balance.

• Not for therapeutic or clinical use.

• Recommended for in vitro and preclinical studies only.

Disclaimer

Myelopeptide-2 is supplied for research use only. It is not approved for human or veterinary applications. All data are provided for scientific and educational purposes to support immunological, antiviral, and oncology research.

Keywords

Myelopeptide-2, CAS 137833-31-9, immunoregulatory peptide, T-cell activation peptide, IL-2 signaling peptide, IL-2 receptor restoration, immune homeostasis peptide, antiviral peptide, antitumor peptide, bone marrow peptide, immune recovery peptide.

Shipping Guarantee

All peptides are packaged in low-temperature, light-protected, vacuum-sealed containers. Analytical reports (HPLC, MS) are included for each batch. Shipments are protected to maintain structural integrity and biological activity.

Transaction Guarantee

Each order is accompanied by a Certificate of Analysis (COA) verifying peptide identity and purity. We offer full replacement or refund in case of quality discrepancies or shipping damage.