Description

Product Description

Myristoyl Pentapeptide-4, also known as Palmitoyl Pentapeptide-4 or Pal-KTTKS, is a lipopeptide formed by linking a short peptide chain to a fatty acid moiety. This modification significantly enhances the peptide’s lipophilicity, improving its ability to penetrate the stratum corneum and interact with underlying skin and follicular structures. In scientific studies, Myristoyl Pentapeptide-4 has been shown to mimic fragments of type I collagen, thereby activating fibroblast function and supporting dermal matrix renewal.

In hair biology research, Myristoyl Pentapeptide-4 is studied for its potential to influence extracellular matrix (ECM) remodeling in the scalp, promote follicle anchoring strength, and improve cellular vitality around hair bulb regions. It is often investigated as part of complex peptide blends designed to address hair thinning and structural fragility. Its molecular activity is linked to upregulation of matrix proteins such as fibronectin, laminin, and collagen types I and III — essential for healthy dermal-epidermal communication.

The peptide sequence KTTKS corresponds to a fragment derived from the C-terminal region of type I collagen, which naturally acts as a signal to fibroblasts to initiate repair mechanisms. Myristoyl conjugation further enhances the bioavailability of this peptide, allowing deeper dermal penetration. Studies in cosmetic science have shown that formulations containing Myristoyl Pentapeptide-4 can support smoother skin texture, increased elasticity, and improved resistance to mechanical stress, making it relevant for anti-aging and scalp vitality research.

Beyond its dermatological relevance, Myristoyl Pentapeptide-4 has attracted attention for its molecular role in promoting gene expression related to ECM stabilization and anti-inflammatory signaling. By reducing cytokine imbalance and oxidative damage, it may indirectly support a healthier environment for hair growth and scalp integrity. This multifaceted action profile has made it a leading peptide in cosmetic research targeting both skin repair and hair growth stimulation.

The peptide’s excellent stability, compatibility with various carriers, and predictable safety profile under laboratory conditions make it an ideal candidate for formulation testing. It has been widely included in research on peptide-based cosmeceutical systems, particularly for anti-aging and scalp care prototypes.

Myristoyl Pentapeptide-4 is available at ≥99% purity and intended exclusively for scientific and laboratory studies. It is not a drug, medical ingredient, or finished cosmetic. All data refer to in vitro or ex vivo studies designed to explore biochemical activity and structure-function relationships.

Product Specifications

Mechanism of Action

1. Peptide Signaling and Collagen Activation

Myristoyl Pentapeptide-4 is structurally derived from the collagen sequence Lys–Thr–Thr–Lys–Ser (KTTKS). This short peptide functions as a biochemical messenger that signals fibroblasts to increase collagen synthesis. By mimicking natural collagen degradation fragments, it induces a restorative response that enhances extracellular matrix (ECM) integrity. When conjugated with a myristoyl fatty acid group, the molecule exhibits significantly improved skin and scalp penetration, allowing effective interaction with dermal fibroblasts and follicular cells.

2. Role in Hair Growth and Follicular Support

In scalp biology research, Myristoyl Pentapeptide-4 has been shown to stimulate fibroblast activity in the papillary dermis surrounding the hair follicle bulb. The improved ECM environment enhances anchoring and mechanical stability of follicles, potentially counteracting hair miniaturization processes. Some research suggests synergistic effects with copper peptides or other growth-stimulating agents, as the peptide promotes matrix protein synthesis while reducing inflammatory stress markers.

3. Anti-Aging and Tissue Regeneration Effects

Myristoyl Pentapeptide-4 promotes dermal rejuvenation by encouraging fibroblast proliferation, increasing production of glycosaminoglycans (GAGs), and reinforcing the structural density of collagen fibrils. These molecular actions contribute to reduced wrinkle appearance and improved firmness in skin tissue research. By normalizing ECM turnover and inhibiting matrix metalloproteinase (MMP) activity, it further supports tissue longevity and mechanical resilience.

4. Anti-Inflammatory and Oxidative Stress Regulation

Research suggests that Myristoyl Pentapeptide-4 may attenuate the expression of pro-inflammatory cytokines such as IL-6 and TNF-α, which are often elevated in scalp irritation and skin aging models. By reducing inflammatory signaling, the peptide contributes to a more favorable microenvironment for cellular repair. Additionally, its indirect antioxidant effect helps protect fibroblasts and keratinocytes from oxidative stress induced by UV radiation and pollution.

5. Enhanced Penetration and Stability via Myristoylation

The conjugation of the KTTKS peptide with a myristoyl group is essential to its effectiveness. The lipid tail increases molecular affinity for biological membranes, thereby improving bioavailability and residence time in the skin. This structural design allows sustained release and extended activity at the target site, which is particularly beneficial in formulations for both skin and scalp research.

Side Effects

In controlled laboratory environments, Myristoyl Pentapeptide-4 has demonstrated a favorable safety profile. It is non-toxic to human fibroblasts and keratinocytes at typical research concentrations and exhibits no mutagenic or sensitizing potential in in vitro assays. Nevertheless, like all research chemicals, it must be handled with standard laboratory precautions. Potential irritation or allergic reactions could occur if improperly formulated or exposed to biological systems beyond experimental settings.

Researchers should avoid inhalation and direct skin or eye contact with concentrated powder. When studying peptide formulation behavior, attention should be paid to pH stability, carrier compatibility, and avoidance of oxidizing agents that may degrade peptide bonds.

This peptide is intended solely for laboratory research use, and not for human or animal application.

Keywords

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Shipping Guarantee

All Myristoyl Pentapeptide-4 shipments are handled using validated cold-chain logistics to preserve peptide integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage.

Trade Assurance

We Myristoyl Pentapeptide-4 ensure product authenticity, verified ≥99% purity, and compliance with analytical standards (HPLC, MS, and NMR). Each batch is supplied with a Certificate of Analysis (CoA). Our trade assurance policy guarantees replacement or refund for any deviation from listed specifications.

Payment Support

We Myristoyl Pentapeptide-4 provide flexible and secure global payment options to support international research transactions. Accepted payment methods include PayPal, major credit cards (Visa, MasterCard, American Express), telegraphic transfer (T/T), and cryptocurrencies (USDT, Bitcoin, Ethereum). All transactions are protected by industry-standard encryption and verified payment gateways to ensure confidentiality and fund security.

Disclaimer

All Myristoyl Pentapeptide-4 products listed are intended for laboratory research use only and not for human or veterinary use. They are not drugs, medical devices, or diagnostics and should not be administered to humans or animals. Researchers must handle all materials in accordance with institutional biosafety and chemical safety guidelines. The information provided is for scientific reference only and does not imply therapeutic efficacy, safety, or regulatory approval.