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NODAGA-LM3 – High Purity 99.33% – GMP Manufacturer
$2.00
NODAGA-LM3 is a GMP-grade, high-purity (99.33%) peptide antagonist targeting SSTR2, suitable for efficient Gallium-68 labeling and PET imaging studies of neuroendocrine tumors. For laboratory research use only.?For wholesale prices, other specifications and uses, please consult our staff?
Description
NODAGA-LM3 is a synthetic peptide-based SSTR2 antagonist incorporating the NODAGA chelator for rapid and efficient labeling with Gallium-68. It is particularly suited for PET imaging of SSTR2-positive neuroendocrine tumors, including paragangliomas. This antagonist form allows high tumor binding and contrast even when receptor activation is not present. With GMP-level purity of 99.33%, NODAGA-LM3 provides consistent performance for preclinical and translational imaging research. Intended strictly for laboratory research use only.
Product Specifications
| Parameter | Details |
|---|---|
| Product Name | NODAGA-LM3 |
| Synonyms | NODAGA-LM3 (antagonist) |
| Purity | 99.33% (GMP-grade) |
| Mechanism | SSTR2 antagonist; Gallium-68 chelator conjugate |
| Labeling Capability | Efficiently labeled with ^68Ga for PET imaging |
| Appearance | White to off-white solid powder |
| Solubility | Soluble in aqueous buffers; DMSO may assist dissolution |
| Storage Conditions | Store at –20 °C in sealed, protected environment |
| Applications | PET imaging of SSTR2-positive tumors; neuroendocrine tumor research; radionuclide-drug conjugate studies |
| Regulatory Status | For laboratory research use only |
Mechanism of Action & Research Applications
Mechanism of Action:
NODAGA-LM3 acts as a high-affinity antagonist for the somatostatin receptor subtype 2 (SSTR2). When labeled with the PET isotope Gallium-68 (^68Ga), it enables high-contrast imaging due to strong receptor binding without the need for receptor activation, resulting in enhanced lesion visibility.
Research Applications:
Neuroendocrine Tumor Imaging: Ideal for PET imaging of paragangliomas and other SSTR2-positive tumors.
Radionuclide-Drug Conjugate (RDC) Studies: Excellent for developing and evaluating novel imaging or therapeutic compounds.
Preclinical and Translational Studies: Supports biodistribution, dosimetry, and imaging performance research.
Side Effects (Research Context Only)
This compound is intended only for in vitro and preclinical imaging research. Human clinical safety data is not provided. Always follow institutional safety protocols when handling.
Disclaimer
NODAGA-LM3 is strictly for laboratory research use only. It is not approved for diagnostic or therapeutic use in humans. Handle and store according to institutional safety and regulatory guidelines.
Additional information
| Weight | 0.6 kg |
|---|---|
| Dimensions | 35 × 24 × 35 cm |
What is NODAGA-LM3 used for in research?
It is used as an SSTR2 antagonist labeled with Gallium-68 for PET imaging of neuroendocrine tumors.
What is its purity?
The product is supplied at 99.33% purity, manufactured under GMP standards.
How does NODAGA-LM3 function?
As a chelated SSTR2 antagonist, it binds strongly to receptors and is effective even without receptor activation, improving imaging sensitivity.
Which tumors is it best suited for imaging?
Primarily paragangliomas and other tumors that express SSTR2.
How should it be stored?
Store at –20 °C in a sealed condition, protected from light and moisture to ensure stability.
Is NODAGA-LM3 approved for clinical use?
No — strictly for laboratory research use only.
Is wholesale available?
Yes — available in both wholesale and retail quantities, with GMP-level manufacturing.
Can it be used for developing new radiopharmaceuticals?
Absolutely — ideal for radiosynthesis and design of novel Gallium-68 tagged drug conjugates.
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