Description

Product Description

Octreotide is a synthetic octapeptide widely utilized in laboratory settings to study molecular mechanisms associated with somatostatin-related pathways, receptor signaling, and peptide–receptor interactions. As a highly stable and well-characterized analog, Octreotide provides researchers with a robust tool for evaluating biochemical responses, receptor affinity profiles, and downstream signaling cascades under controlled experimental conditions. Its lyophilized form ensures extended shelf stability and consistent reconstitution properties, enabling reproducible results across diverse research workflows.

The molecular structure of Octreotide incorporates key amino acid modifications designed to enhance stability and resistance to degradation, making it suitable for extended study durations and multi-step biochemical assays. Because of this high structural integrity, researchers frequently employ Octreotide in receptor-binding investigations, signal transduction analyses, and studies involving somatostatin-related pathways. Its affinity for specific receptor subtypes allows precise interrogation of receptor behavior in vitro, supporting mechanistic explorations in controlled laboratory environments.

The freeze-dried presentation of Octreotide ensures ease of handling while maintaining the peptide’s integrity during long-term storage. Laboratories appreciate the consistent batch-to-batch purity, which allows experimental designs to remain dependable, especially when quantifying molecular interactions or analyzing peptide-protein complex stability. The form also offers flexibility in preparing stock solutions or aliquots suitable for kinetic assays, receptor profiling, and biochemical modeling.

Researchers further utilize Octreotide to observe regulatory influences on enzyme activity, protein conformational changes, and intracellular signaling pathway modulation. Its precision and reliability make it valuable for comparative experiments, standard curve generation, and functional receptor assays. Because Octreotide interacts selectively with somatostatin receptors, it supports controlled laboratory exploration of receptor subtype preference, desensitization patterns, and ligand–receptor kinetics.

Quality-controlled, factory-manufactured Octreotide ensures that each batch adheres to stringent purity criteria validated through HPLC, MS, and other analytical methods. This provides researchers with confidence in the molecule’s consistency and suitability for advanced biochemical research. Whether used in structural analysis, receptor-ligand mechanistic studies, or molecular interaction screening, Octreotide remains a key component in peptide-focused laboratory research.

Product Specifications

Additional Notes:

• Each batch includes COA, MSDS, and impurity chromatograms for traceability.

• Sterile-filtered preparation can be provided upon request for cell-culture applications.

Mechanism of Action

Octreotide functions as a synthetic somatostatin analog engineered to interact with a subset of somatostatin receptors (primarily SSTR2 and SSTR5) with significantly higher stability and prolonged activity compared with endogenous somatostatin-14. Its mechanism is centered on high-affinity GPCR-mediated inhibitory signaling, making it a valuable tool for controlled perturbation studies across neuroendocrine, metabolic, and cellular-signaling research domains.

Receptor Binding & Primary Signal Initiation

Upon contact with responsive cellular systems, Octreotide binds to somatostatin receptors, which belong to the G-protein–coupled receptor (GPCR) superfamily. The interaction is strongest with SSTR2, followed by SSTR5, both of which regulate secretory and proliferative processes in many endocrine and neuroendocrine model systems. Receptor engagement triggers coupling with Gi/o proteins, resulting in suppression of adenylyl cyclase activity. This decreases intracellular cAMP levels, altering downstream kinase activity (PKA and related signaling intermediates). Reduced cAMP serves as a major checkpoint that reshapes hormonal secretion pathways, ion-channel modulation, and vesicle-dynamics patterns.

Ion Channel & Calcium Regulation

Octreotide-driven GPCR activation also modulates voltage-gated calcium channels, reducing calcium influx and consequently lowering the activity of calcium-dependent exocytotic machinery. This regulatory action is essential for studies focused on hormone-release mechanisms, as it provides a consistent and quantifiable method to evaluate how reduced intracellular calcium impacts synaptic-like vesicle fusion, SNARE-complex behavior, and endocrine system responsiveness.

MAPK, PI3K/AKT, and Additional Downstream Nodes

In addition to cAMP suppression, Octreotide influences several major regulatory pathways, including MAPK/ERK, PI3K/AKT, and PLC/PKC networks. These effects may vary by receptor subtype expression, cell type, and experimental conditions. Gene-expression analyses frequently show shifts in regulators of proliferation, differentiation markers, cytoskeletal reorganization, and metabolic enzymes. Somatostatin receptor activation can also influence apoptotic pathway mediators, contributing to its widespread use in tumor and stress-response modeling.

Modulation of Secretory Networks

A central functional feature of Octreotide is its ability to downregulate multiple endocrine secretion pathways. It suppresses synthesis-associated transcriptional regulators and reduces exocytosis from secretory granules via altered ion-channel and vesicle-trafficking behavior. This makes Octreotide a powerful reference compound in endocrine circuit mapping, hormone-regulation screens, and peptide-secretion research.

Systems-Level Implications

Because Octreotide targets highly conserved GPCR networks, its influence spans transcriptomic, proteomic, and metabolomic systems. It introduces predictable inhibitory signatures across multiple biological layers, making it valuable in systems pharmacology, network reconstruction, signal-perturbation mapping, and somatostatin-receptor functional studies. The clarity and reproducibility of its receptor-mediated responses support its integration into multi-omic workflows and computational modeling frameworks to dissect endocrine and neuroendocrine regulatory structures.

Applications

Octreotide’s diverse biochemical activities make it suitable for a broad spectrum of laboratory investigations. In endocrine signaling research, it is widely used to explore GH axis suppression, insulin-glucagon dynamics, pancreatic β-cell regulatory mechanisms, and pituitary modulation. Its strong activity at SSTR2/5 provides targeted control of hormone-secreting cell populations for pathway-specific experiments.

In cancer biology, Octreotide is employed in neuroendocrine tumor models to assess anti-proliferative signaling, angiogenesis suppression, and tumor-secretome modulation. Studies often integrate Octreotide to evaluate receptor expression profiles or as a reference agonist when screening new somatostatin-pathway modulators.

In gastrointestinal and metabolic research, Octreotide assists in examining gastric emptying dynamics, intestinal secretion rates, pancreatic exocrine control, and peptide-mediated gut-brain-axis communication. Organoid and microfluidic gut models particularly benefit from its predictable and receptor-specific actions.

Additional application domains include:

• Receptor-binding studies and ligand-affinity profiling

• Computational modeling of endocrine microcircuits

• In vivo pharmacokinetic evaluations

• High-content imaging of somatostatin receptor trafficking

Research Models

Octreotide is widely incorporated into diverse research models because of its stable activity, selective somatostatin-receptor affinity, and predictable inhibitory signaling behavior. Its reproducible performance makes it a standard reference compound across endocrine, neuroendocrine, metabolic, and cellular-signal–modulation studies. The following categories outline how laboratories integrate Octreotide into controlled experimental systems while adhering strictly to research-only parameters.

Endocrine Pathway Modulation Models

Octreotide is frequently used in in-vitro endocrine models designed to evaluate somatostatin-receptor–controlled pathways. Systems expressing SSTR2 or SSTR5 allow investigators to study receptor selectivity, second-messenger suppression, transcriptional-regulator shifts, and regulatory loops associated with hormonal suppression. These models provide a controlled environment to map peptide–GPCR interactions, modulate inhibitory signaling, and benchmark receptor-dependent transcriptional signatures.

Neuroendocrine Signal-Pathway Frameworks

In neuroendocrine research models, Octreotide serves as a consistent signaling-perturbation tool used to explore neuronal–secretory regulation, calcium-channel behavior, and the molecular dynamics of vesicle systems. Laboratory models focusing on neuropeptide regulatory axes use Octreotide to assess GPCR-coupled feedback networks, identify differential receptor expression patterns, and study cross-talk between somatostatin receptor families and downstream kinase cascades.

Cellular Signaling & GPCR Investigation Systems

Research platforms using engineered cell lines or primary cellular constructs often incorporate Octreotide to analyze GPCR-mediated inhibitory signaling across cAMP, MAPK, PI3K/AKT, and PLC pathways. Because Octreotide produces clear, dose-dependent regulatory signatures, it is well suited for mechanistic studies on kinase regulation, signal-cascade dampening, cytoskeletal remodeling, and apoptotic-pathway engagement. Multi-receptor expression models also allow comparative assessment of SSTR-subtype–specific responses.

Secretory-Granule & Exocytosis Models

A major application of Octreotide in research models centers on its ability to reduce calcium-dependent exocytotic processes. Secretory-cell culture systems—whether neuroendocrine, endocrine, or receptor-engineered—use Octreotide to quantify changes in granule trafficking, vesicle-fusion metrics, SNARE-complex configuration, and secretion-associated transcriptional adjustments. Its reproducible suppression of exocytotic activation makes it a reference compound in mechanistic secretion research.

Proliferation, Differentiation & Stress-Response Panels

Octreotide is incorporated into cellular panels exploring proliferation checkpoints, differentiation markers, oxidative-stress responses, and survival pathways. These models rely on somatostatin-receptor activation to regulate MAPK/ERK and AKT kinetics, enabling controlled perturbation of proliferative behaviors in receptor-positive systems. Studies focusing on stress signaling and homeostatic feedback also employ Octreotide to investigate how inhibitory GPCR signaling influences stress-adaptation networks.

Multi-Omic & Computational Research Models

In transcriptomic, proteomic, and metabolomic workflows, Octreotide provides a stable inhibitory signature that supports model training, computational predictions, and systems-biology analyses. Research groups frequently integrate Octreotide into network-reconstruction frameworks to validate pathway inference, receptor-interaction modeling, and multivariate clustering linked to GPCR-driven regulatory behavior. Its predictable multi-level effects enable use in simulation-based models and algorithmic pathway-validation pipelines.

Comparative Peptide-Analog Modeling

Octreotide is also used in comparative panels evaluating synthetic peptide analogs designed to target the same receptor families. These models help establish structure–activity relationships, identify receptor-affinity differentials, and benchmark kinetic properties against known somatostatin analogs. Because Octreotide exhibits strong and consistent receptor bias, it serves as a robust reference for analog-profiling studies.

Experimental Design Considerations

When designing Octreotide experiments, ensure that dosing concentration matches the receptor density and metabolic turnover of the selected model. Lyophilized stocks should be reconstituted with sterile saline or dilute acetic acid at the desired molarity and prepared fresh when possible to avoid peptide oxidation.

Time-course sampling is essential for accurate interpretation of endocrine suppression dynamics, as Octreotide exhibits sustained receptor activity relative to native somatostatin. Parallel controls—such as untreated samples, receptor antagonist groups, or natural somatostatin comparators—are recommended to differentiate mechanism-specific outcomes.

For in vivo studies, consider circadian variations in hormone release and administer Octreotide at consistent intervals. For in vitro work, avoid buffers with high protease activity and validate peptide stability using LC-MS or HPLC when conducting long experiments.

Laboratory Safety & Handling Guidelines

Proper laboratory practice is essential when working with Octreotide in its freeze-dried powder form, particularly because peptide-based research materials require controlled handling to maintain stability, purity, and reproducibility across experiments. Although Octreotide is not intended for human or veterinary use, rigorous adherence to institutional biosafety protocols ensures safe operation and preserves the integrity of scientific results.

Storage & Stability Management

Octreotide should be stored at –20 °C or below in its sealed, lyophilized state to maintain structural fidelity and minimize degradation. The peptide is hygroscopic, meaning exposure to moisture may alter its stability; therefore, vials must remain tightly sealed until use. Once reconstituted, working solutions should be handled under low-temperature conditions, protected from light, and used promptly to minimize peptide oxidation or aggregation. Where possible, single-use aliquots are recommended to reduce repeated freeze–thaw cycles, as these can compromise experimental consistency.

Handling Precautions

Standard PPE—including laboratory gloves, protective eyewear, and appropriate lab coats—should be worn whenever handling Octreotide, whether in powder or solution form. Opening vials should be performed in a clean, low-particulate workspace such as a chemical safety cabinet or laminar-flow hood when feasible. Peptide powders can become airborne if mishandled; therefore, avoid direct airflow, rapid uncapping, or mechanical shocks that may disturb the lyophilized material. Use calibrated micropipettes and sterile vessels for accurate reconstitution and measurement.

Contamination Avoidance & Traceability

To safeguard against cross-contamination, all contact surfaces, tools, and containers must be cleaned or sterilized before interacting with the material. Dedicated consumables should be used when conducting sequential assays. Maintaining precise chain-of-custody and documentation—including lot numbers, dates of opening, and storage conditions—ensures traceability and supports reproducible research outcomes. Researchers should follow internal QA/QC policies, including regular equipment calibration and proper sample-labeling procedures.

Waste Disposal & Environmental Controls

Unused or expired Octreotide, along with materials contaminated during experimental work, must be disposed of according to chemical and institutional biosafety rules. Although peptides typically pose low environmental hazard, they should never be released into wastewater systems. Solid waste should be placed in designated chemical-biological collection containers. Laboratories should maintain adequate ventilation, temperature monitoring, and humidity control to prevent unintentional degradation of stored materials.

Emergency Guidelines & Risk Mitigation

In the event of accidental spills, the affected area should be isolated, and personnel must follow spill-response protocols—typically involving gentle wet wiping with suitable cleaning agents and disposal of materials as chemical waste. Direct skin or eye contact should be managed through immediate washing with water and reporting incidents according to safety-office requirements. Training in chemical-handling procedures and familiarity with the product’s MSDS are essential for all users before beginning any research involving Octreotide.

Integration with Multi-Omic & Computational Studies

Integration of Octreotide into multi-omic and computational research pipelines significantly enhances the resolution and interpretability of endocrine and neuroendocrine signaling studies. Because Octreotide modulates well-defined receptor pathways—primarily SSTR2 and SSTR5—it serves as a highly controlled perturbation agent for systems biology analysis. Researchers can map how its receptor activation cascades influence transcriptomic, proteomic, metabolomic, phosphoproteomic, and secretomic signatures across diverse biological contexts.

Multi-Omic Profiling

In transcriptomic studies (bulk RNA-seq or single-cell RNA-seq), Octreotide enables structured investigation of downstream gene-expression responses associated with cAMP suppression, vesicle-trafficking regulation, and hormonal secretion pathways. Somatostatin receptor modulation often produces measurable gene shifts linked to endocrine differentiation, ion-channel regulation, stress-response networks, and tumor-microenvironment remodeling.

Proteomic and phosphoproteomic workflows benefit from Octreotide’s ability to alter key kinase/phosphatase nodes, enabling mapping of SSTR-Gi/o–mediated inhibitory signaling across multiple cell types. LC-MS/MS profiling frequently reveals changes in GPCR-associated scaffolding proteins, vesicle-SNARE regulators, and metabolic enzymes tied to hormone-synthesis control.

In metabolomics, Octreotide supports targeted and untargeted assessments of glucose regulation, amino-acid metabolism, lactate flux, and neuroendocrine metabolic states. Investigators can pair these data with endocrine peptide searches or growth-factor secretion profiles to build a mechanistic multi-layer dataset.

Computational & Systems Biology Integration

Octreotide is particularly valuable in computational modeling, because its receptor-binding kinetics and downstream inhibitory effects are well-characterized. Systems-biology models can incorporate Octreotide as an externally applied perturbation, enabling simulation of endocrine microcircuit behavior, receptor occupancy curves, and hormone-feedback loops using ODE-based or agent-based frameworks.

In network modeling, Octreotide-induced suppression patterns help identify central regulatory nodes in GH, insulin, IGF-1, and angiogenic networks. Using machine learning pipelines, researchers can correlate Octreotide dose-response curves with multi-omic changes to predict receptor expression, ligand-binding variability, or tumor-suppression sensitivity.

Integrated Multi-Omic Pipelines

Modern research increasingly involves cross-platform integration—e.g., combining RNA-seq, mass-spec proteomics, cell-surface receptor profiling, and metabolite flux analysis. Octreotide fits seamlessly into these workflows as a reproducible, tunable molecular control that generates clean perturbation signatures. These datasets feed into computational frameworks to create predictive models for endocrine signaling, tumor responsiveness, or GPCR network adaptation.

Imaging, Spatial-Omics & Receptor Mapping

Fluorescently labeled or radiolabeled Octreotide analogs further support spatial-omics by enabling direct visualization of SSTR distribution in tissues or 3D organoids. When combined with spatial transcriptomics or multiplex immunostaining, researchers can assess how Octreotide reshapes local endocrine microenvironments, especially in neuroendocrine tumor systems.

Shipping Guarantee

All Octreotide shipments use validated cold-chain packaging (2–8 °C), moisture-protected containers, and tamper-evident sealing. Documentation includes COA, MSDS, batch records, and tracked delivery data to ensure full traceability and product stability throughout transport. Additional insulated or dry-ice options are available for extreme-temperature regions.

Trade Assurance

Produced in a GMP-aligned facility, Octreotide undergoes strict QC, including HPLC purity verification, peptide mapping, and microbial load testing. Researchers may request bulk quantities, OEM customization, or institution-specific packaging. Dedicated QC and logistics teams ensure consistent purity, performance reliability, and global supply support.

Payment Support

Supported payment methods include corporate bank transfer, PayPal, major credit cards, and digital-asset transactions for pre-approved institutions. Volume orders may qualify for flexible billing cycles, scheduled purchasing programs, or long-term supply agreements.

Disclaimer

Octreotide (CAS 83150-76-9) is for laboratory research use only.
Not for human or veterinary use.
Researchers must follow institutional, legal, and biosafety regulations when handling, storing, and disposing of this material.

Keywords

Octreotide, freeze-dried powder, somatostatin analog, peptide research, receptor binding, laboratory-only peptide, CAS 83150-76-9, high purity peptide, factory manufactured peptide, wholesale peptide supply

References

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