Description

Product Description

Octreotide Acetate Injection is a chemically synthesized octapeptide structurally related to the natural hormone somatostatin. It is engineered for enhanced stability, extended half-life, and targeted receptor affinity, making it a critical tool for laboratory studies investigating neuroendocrine tumors, acromegaly, and hormone dysregulation.

The peptide sequence allows Octreotide to bind selectively to somatostatin receptors (SSTR2 and SSTR5), mimicking the inhibitory action of endogenous somatostatin on endocrine and exocrine secretions. Laboratory research has demonstrated that Octreotide reduces excessive secretion of growth hormone, insulin, glucagon, and other hormones in experimental models.

This injectable form provides a sterile, ready-to-use reagent for controlled studies, including:

• Analysis of hormone secretion pathways;

• Evaluation of receptor-ligand interactions;

• Preclinical tumor growth inhibition studies;

• Signal transduction and gene expression research in endocrine cells;

• Investigation of gastrointestinal, pancreatic, and pituitary regulatory mechanisms.

Due to its pharmacological profile, Octreotide Acetate Injection allows researchers to model endocrine disorders, investigate tumor biology, and study receptor-mediated intracellular pathways. Its stability and solubility ensure reproducible results in both in vitro assays and in vivo animal studies.

Product Specifications

Mechanism of Action

Octreotide Acetate Injection functions as a potent somatostatin analog, mediating effects through somatostatin receptors and downstream intracellular signaling cascades.

1. Endocrine Inhibition

Octreotide binds to somatostatin receptors SSTR2 and SSTR5 on pituitary, pancreatic, and gastrointestinal cells, inhibiting secretion of growth hormone, insulin, and glucagon. This receptor-mediated effect allows detailed mechanistic studies of endocrine signaling and hormone feedback loops.

2. Tumor Growth Modulation

In neuroendocrine tumor models, Octreotide suppresses proliferation and induces cell cycle arrest via receptor-mediated inhibition of growth-promoting pathways. It also reduces tumor angiogenesis by modulating VEGF signaling and other pro-angiogenic factors.

3. Intracellular Signal Transduction

Upon receptor binding, Octreotide activates inhibitory G-protein coupled pathways, reducing cAMP levels and influencing calcium channel activity. These pathways regulate hormone secretion, cellular proliferation, and apoptosis in endocrine and tumor cells.

4. Gastrointestinal and Pancreatic Effects

Octreotide inhibits secretion of digestive hormones including gastrin, vasoactive intestinal peptide (VIP), and secretin. This effect is leveraged in preclinical studies to understand gastrointestinal motility, enzyme release, and pancreatic regulation.

5. Immunomodulatory Research Applications

Recent studies indicate Octreotide can modulate immune cell activity, influencing cytokine profiles and inflammatory signaling, which provides a model for investigating tumor-immune interactions in vitro and in vivo.

Side Effects

Octreotide Acetate Injection is intended strictly for controlled laboratory use. Potential research-related considerations include:

• Dose-dependent cytotoxicity in sensitive cell lines;

• Hormone suppression effects in animal models;

• Possible off-target receptor interactions at high concentrations.

Proper laboratory safety practices, aseptic handling, and adherence to institutional animal care guidelines are required. This product is not intended for clinical or human use.

Keywords

Octreotide Acetate Injection, somatostatin analog, endocrine research, tumor biology, hormone inhibition, receptor signaling, laboratory peptide supplier, high-purity peptide injection

Shipping Guarantee

All shipments are handled using validated cold-chain logistics to preserve peptide integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage.

Trade Assurance

We ensure product authenticity, verified ≥99% purity, and compliance with analytical standards (HPLC, MS, and NMR). Each batch is supplied with a Certificate of Analysis (CoA). Our trade assurance policy guarantees replacement or refund for any deviation from listed specifications.

Payment Support

We provide flexible and secure global payment options to support international research transactions. Accepted payment methods include PayPal, major credit cards (Visa, MasterCard, American Express), telegraphic transfer (T/T), and cryptocurrencies (USDT, Bitcoin, Ethereum). All transactions are protected by industry-standard encryption and verified payment gateways to ensure confidentiality and fund security.

Disclaimer

All products listed are intended for laboratory research use only and not for human or veterinary use. They are not drugs, medical devices, or diagnostics and should not be administered to humans or animals. Researchers must handle all materials in accordance with institutional biosafety and chemical safety guidelines. The information provided is for scientific reference only and does not imply therapeutic efficacy, safety, or regulatory approval.