Description

Product Description

Oligopeptide-6 is a short-chain bioactive peptide known for its moisturizing, skin-repairing, and barrier-strengthening effects in cosmetic and dermatological research. As a synthetic oligopeptide, it mimics natural skin peptides that regulate hydration and epidermal renewal, helping maintain the skin’s integrity and resilience under environmental stress.

In skin physiology, water balance and barrier protection are fundamental to maintaining youthful, healthy-looking skin. Disruption of this balance through dehydration, UV exposure, or aging leads to increased transepidermal water loss (TEWL), resulting in roughness, fine lines, and loss of elasticity. Oligopeptide-6 has demonstrated the ability to boost hydration at the cellular level, promote lipid barrier recovery, and support the natural synthesis of ceramides — key molecules that seal moisture within the stratum corneum.

As a research peptide, Oligopeptide-6 exhibits dual functionality: (1) improving water retention through epidermal stimulation, and (2) enhancing cellular communication between keratinocytes and fibroblasts, which facilitates tissue repair and matrix remodeling. This activity profile makes it valuable in the development of moisturizing and anti-aging formulations focused on restoring the skin’s natural protective function.

Scientific findings suggest that Oligopeptide-6 can upregulate aquaporin-3 (AQP3) expression, the protein channel responsible for water and glycerol transport in the epidermis. By activating AQP3, the peptide enhances the skin’s ability to absorb and retain moisture efficiently. Additionally, Oligopeptide-6 promotes the production of hyaluronic acid and collagen, two essential biomolecules that help maintain smoothness, suppleness, and volume.

In cosmetic formulation research, Oligopeptide-6 is frequently studied as part of moisturizing peptide complexes alongside ingredients such as Palmitoyl Tetrapeptide-7, Acetyl Hexapeptide-37, and Oligopeptide-20. These synergistic blends have shown promising potential for improving long-term skin hydration and repairing barrier damage caused by environmental stressors.

The peptide’s stability, solubility, and compatibility with aqueous systems make it suitable for integration into serums, gels, and emulsions used in controlled laboratory testing environments.

Product Specifications

Mechanism of Action

1. Aquaporin-3 (AQP3) Stimulation

Oligopeptide-6 increases the expression of AQP3 in keratinocytes, facilitating the transport of water and glycerol across the epidermal layer. This enhances skin hydration and supports lipid balance, helping to maintain smooth, supple texture.

2. Barrier Lipid Synthesis

The peptide promotes the regeneration of essential lipids such as ceramides and fatty acids, reinforcing the skin’s barrier function. This minimizes transepidermal water loss (TEWL) and provides sustained hydration under environmental stress.

3. Collagen and Hyaluronic Acid Production

Oligopeptide-6 stimulates fibroblast activity, leading to enhanced collagen and hyaluronic acid synthesis. These components improve skin firmness, elasticity, and moisture retention, aligning with anti-aging research findings.

4. Epidermal Communication Enhancement

By acting as a signaling molecule, Oligopeptide-6 strengthens intercellular communication between epidermal and dermal layers, optimizing the skin’s natural renewal cycle.

5. Antioxidant Protection

The peptide helps reduce oxidative damage induced by UV exposure and pollution by modulating antioxidant enzyme levels and preventing lipid peroxidation. This protects the skin’s structural proteins from degradation.

Collectively, these mechanisms highlight Oligopeptide-6 as a promising ingredient in cosmetic research targeting hydration, barrier restoration, and anti-aging.

Side Effects

Oligopeptide-6 demonstrates an excellent safety and biocompatibility profile in in vitro studies. It is non-cytotoxic, non-irritant, and stable under normal formulation pH ranges. No genotoxic or allergenic effects have been observed in laboratory testing.

While Oligopeptide-6 is intended for research use only, it provides a reliable model for evaluating the biochemical processes involved in hydration and skin barrier restoration. Researchers should follow standard biosafety protocols and avoid direct application to human or animal skin outside approved testing environments.

The peptide remains stable for up to 24 months when stored in sealed containers at −20°C and protected from light.

Keywords

Oligopeptide-6, moisturizing peptide, skin hydration peptide, barrier repair peptide, cosmetic raw material manufacturer, peptide wholesale China, factory peptide supplier, high-purity cosmetic peptide, China peptide manufacturer, OEM peptide production

Shipping Guarantee

All shipments are handled using validated cold-chain logistics to preserve peptide integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage.

Trade Assurance

We ensure product authenticity, verified ≥99% purity, and compliance with analytical standards (HPLC, MS, and NMR). Each batch is supplied with a Certificate of Analysis (CoA). Our trade assurance policy guarantees replacement or refund for any deviation from listed specifications.

Payment Support

We provide flexible and secure global payment options to support international research transactions. Accepted payment methods include PayPal, major credit cards (Visa, MasterCard, American Express), telegraphic transfer (T/T), and cryptocurrencies (USDT, Bitcoin, Ethereum). All transactions are protected by industry-standard encryption and verified payment gateways to ensure confidentiality and fund security.

Disclaimer

All products listed are intended for laboratory research use only and not for human or veterinary use. They are not drugs, medical devices, or diagnostics and should not be administered to humans or animals. Researchers must handle all materials in accordance with institutional biosafety and chemical safety guidelines. The information provided is for scientific reference only and does not imply therapeutic efficacy, safety, or regulatory approval.