Oximbomotide | CAS No. 2306406-51-7

Description

Product Description

Oximbomotide (CAS 2306406-51-7) represents an emerging class of antineoplastic immunological agents designed to induce active immune responses against tumors. Unlike traditional chemotherapeutics, which directly target tumor cell growth or survival, immunological agents like Oximbomotide harness the body’s own adaptive immune system to selectively attack malignant cells.

Background in Cancer Immunotherapy

• Cancer immunotherapy has gained global recognition as a fourth pillar of cancer treatment, alongside surgery, chemotherapy, and radiotherapy.

• Active immunization approaches aim to train the immune system to recognize tumor-associated antigens (TAAs) or tumor-specific antigens (TSAs).

• Oximbomotide belongs to this category, designed to enhance immune recognition of cancer cells and sustain long-term antitumor memory.

Research Significance

1. Cancer Vaccine Development

   • Oximbomotide provides a model for studying peptide- or protein-based cancer vaccines.

   • It demonstrates the potential to induce cytotoxic T lymphocyte (CTL) responses capable of killing tumor cells.

2. Antineoplastic Immunological Agent

   • Functions by enhancing immune detection and response against malignant tissues.

   • Can be combined with immune checkpoint inhibitors for synergistic effects.

3. Preclinical Oncology Studies

   • Used in animal and cellular models to evaluate tumor regression, immune activation, and long-term immunological memory.

4. Personalized Medicine

   • Contributes to research on patient-specific neoantigen vaccines.

   • Illustrates the broader movement toward tailored immunotherapy approaches.

Product Specifications

Notes

• Supplied in sterile vials.

• Endotoxin-free preparations available for sensitive experiments.

• For research use only.

Mechanism of Action

Oximbomotide operates through active immunization principles, stimulating the adaptive immune system to mount antitumor responses.

1. Antigen Presentation

   • Oximbomotide introduces or mimics tumor antigens.

   • Antigen-presenting cells (APCs) such as dendritic cells process and present peptides on MHC class I and II molecules.

2. Activation of Cytotoxic T Cells

   • Stimulates CD8+ cytotoxic T lymphocytes (CTLs) to recognize and kill tumor cells displaying the corresponding antigen.

3. Helper T Cell Support

   • CD4+ helper T cells are activated, releasing cytokines like IL-2 and IFN-γ.

   • Provides necessary support for CTL proliferation and B cell activation.

4. B Cell Response

   • Can induce humoral immune responses.

   • Antibody production may facilitate tumor cell opsonization and complement activation.

5. Long-Term Immunological Memory

   • Creates memory T and B cells capable of recognizing tumor antigens upon recurrence.

   • Supports sustained surveillance against malignant cells.

6. Synergistic Approaches

   • When combined with immune checkpoint inhibitors (e.g., anti-PD-1, anti-CTLA-4), Oximbomotide-induced T cells remain more active and resistant to tumor-induced immunosuppression.

     

Side Effects

Research Observations

• Generally exhibits favorable safety profiles in preclinical models.

• Immune activation can produce local inflammation at the site of administration.

Potential Research Risks

• Risk of autoimmunity if immune response cross-reacts with normal tissues.

• Possible cytokine-mediated side effects such as fatigue, fever, or systemic inflammation in vivo.

• Long-term safety requires continued research.

Laboratory Safety Notes

• Handle with biosafety precautions appropriate for immunological agents.

• Not approved for therapeutic use in humans.

• Use sterile technique to prevent contamination.

Disclaimer

This product is intended for research purposes only. Oximbomotide is not approved for clinical or diagnostic use in humans.

Keywords

Oximbomotide, CAS 2306406-51-7, active immunization agent, antineoplastic immunological compound, cancer vaccine research, immuno-oncology peptide, tumor immune activation.

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