No products in the cart.
Sale
Paclitaxel 30mg | CAS 33069-62-4 | Cytotoxicity and Cell-Cycle Arrest Research (Solution, Bulk Wholesale)
Original price was: $5.00.$3.00Current price is: $3.00.
Paclitaxel (CAS 33069-62-4) is a high-purity microtubule-stabilizing anticancer compound supplied as a research-grade solution for preclinical studies. It is widely used to investigate cytotoxicity, microtubule dynamics, mitotic arrest, apoptosis induction, and drug-resistance mechanisms in molecular and cellular oncology research. Bulk and wholesale supply options are available.
Description
Contents
hide
Product Description
Paclitaxel (CAS 33069-62-4) is a natural diterpenoid compound from the taxane family, widely employed as a microtubule-stabilizing agent in preclinical oncology research. Its solution form allows for precise dosing, improved solubility, and reproducible delivery for in vitro and in vivo studies.
Paclitaxel binds to the β-subunit of tubulin, promoting polymerization and inhibiting depolymerization, thereby stabilizing microtubules. This hyperstabilization interferes with spindle assembly, arrests cells in G2/M phase, and induces apoptosis through intrinsic mitochondrial pathways. Researchers commonly use Paclitaxel solution to explore mitotic checkpoint signaling, cytotoxicity, apoptosis, combination therapy effects, and resistance mechanisms such as P-glycoprotein efflux and β-tubulin isotype switching.
The solution form ensures compatibility with high-throughput screening, microplate-based assays, and reproducible experimental setups. Bulk and wholesale options allow laboratories to conduct extended studies and multi-batch experiments without variability, supporting applications in cytotoxicity studies, cell-cycle regulation research, drug combination assays, and mechanistic pathway investigations.
Product Specifications
| Parameter | Specification / Data |
|---|---|
| Chemical Name / Synonyms | Paclitaxel; Taxol; NSC 125973 |
| CAS Number | 33069-62-4 |
| Molecular Formula | C47H51NO14 |
| Molecular Weight | 853.91 g/mol |
| Purity / Assay | ≥99% |
| Appearance | Clear to slightly yellow solution |
| Dosage Form | Solution for research use |
| Solvent | DMSO, ethanol, or mixed solvent (custom per batch) |
| Concentration | 1–10 mg/mL (customizable) |
| Storage Temperature | –20 °C; protect from light |
| Stability | Stable under frozen conditions; avoid repeated freeze-thaw cycles |
| Mechanistic Target | β-tubulin; microtubule polymerization; mitotic arrest |
| Structural Category | Taxane; microtubule-stabilizing agent |
| Applications | Cytotoxicity assays, apoptosis research, mitotic arrest studies, combination therapy research, drug-resistance modeling |
| Analytical Verification | HPLC, MS, NMR |
| Regulatory Notes | For laboratory research use only |
| Origin | Factory small-molecule supplier, China; bulk & wholesale available |
| Additional Data | SMILES: CC1=C2C(=C(C(=O)O2)OC3C(C(C(O3)CO)O)OC(=O)C4=CC=CC=C4)C(=O)OC5C(C(C(O5)CO)O)OC(=O)C6=CC=CC=C6 |
Mechanism of Action
Microtubule Stabilization
Paclitaxel binds to β-tubulin within microtubules, enhancing polymerization and preventing depolymerization. This stabilizes microtubules, interferes with dynamic spindle formation, and disrupts normal chromosome segregation.
Mitotic Arrest & Checkpoint Activation
Induces prolonged G2/M phase arrest
Activates spindle assembly checkpoint (SAC) proteins (MAD2, BUB1, BUBR1)
Causes cyclin B1 accumulation and mitotic block
Apoptosis Induction
Triggers intrinsic mitochondrial apoptotic pathway
Mitochondrial depolarization and cytochrome c release
Caspase-9 and caspase-3 activation
PARP cleavage and ROS generation
Resistance Mechanism Modeling
Paclitaxel is widely used to investigate drug-resistance mechanisms:
P-glycoprotein (P-gp) mediated efflux
β-tubulin isotype switching
Alterations in microtubule-associated proteins (MAPs)
Post-translational modifications affecting tubulin dynamics
Applications
Microtubule polymerization research
Mitotic checkpoint and G2/M arrest studies
Cytotoxicity and apoptosis assays
Drug combination and synergy testing
Resistance mechanism evaluation
High-throughput compound screening
Preclinical in vivo and in vitro pharmacology research
Side Effects (Preclinical Observations)
Cellular Effects:
Mitotic arrest, microtubule hyperstabilization, spindle abnormalities
ROS accumulation and DNA fragmentation
Apoptotic Effects:
Caspase activation and PARP cleavage
Mitochondrial dysfunction
Chromatin condensation and membrane blebbing
Laboratory Handling:
Cytotoxic: use PPE
Handle in fume hood
Avoid contact with skin, eyes, or ingestion
Dispose as hazardous chemical waste
Keywords
Paclitaxel bulk wholesale, CAS 33069-62-4, microtubule stabilizing agent, mitotic arrest reagent, apoptosis research, cytotoxicity research, taxane compound, preclinical oncology reagent, laboratory-grade Paclitaxel, OEM Paclitaxel supplier, solution formulation, high-purity Paclitaxel, bulk supply, research chemical.
Shipping Guarantee
Paclitaxel solution is shipped under validated cold-chain conditions at –20 °C with temperature-stable packaging and secondary protective sealing. International express couriers provide tracking, insurance, and priority delivery to preserve compound integrity.
Trade Assurance
Purity ≥99% verified by HPLC, MS, NMR
Batch consistency validated
Certificate of Analysis (CoA) included
OEM and bulk packaging available
Refund/replacement for any deviations from specification
Payment Support
PayPal
Credit Cards (Visa, MasterCard, AmEx)
Bank Transfer (T/T)
USDT / BTC / ETH
Corporate invoicing for bulk orders
Disclaimer
is for laboratory research only. Not for human or veterinary use. Users must follow institutional safety guidelines and cytotoxic reagent protocols. Supplier assumes no liability for misuse.
References
Additional information
| Weight | 1.1 kg |
|---|---|
| Dimensions | 18 × 16 × 18 cm |
1. What is Paclitaxel Solution used for in research?
It is used to study microtubule stabilization, mitotic arrest, apoptosis, cytotoxicity, and resistance mechanisms.
2. Why choose Paclitaxel Solution over powder?
Solution form improves solubility, dosing accuracy, and reproducibility, especially for high-throughput assays.
3. What is the purity of Paclitaxel Solution?
≥99% verified via HPLC, MS, and NMR.
4. Can bulk or wholesale quantities be ordered?
Yes, bulk and OEM options are available.
5. Which solvents are used?
DMSO, ethanol, or mixed solvent depending on batch.
6. How should it be stored?
–20 °C, protect from light, avoid repeated freeze-thaw.
7. Is Paclitaxel suitable for apoptosis research?
Yes, it induces mitochondrial-mediated apoptosis.
8. Can Paclitaxel be used for combination studies?
Yes, widely used with kinase inhibitors, DNA-damaging agents, and pathway modulators.
9. Can it be used for in vivo studies?
Yes, with proper formulation according to animal research protocols.
10. Is OEM relabeling available?
Yes, OEM and custom packaging available.
11. Can concentration be customized?
Yes, from 1–20 mg/mL.
12. Is this a China chemical manufacturer product?
Yes, sourced from verified factory suppliers.
13. What pathways are affected by Paclitaxel?
Microtubule polymerization, SAC activation, apoptosis signaling, ROS pathways.
14. Does it cause ROS generation?
Yes, contributing to cytotoxic stress and apoptosis.
15. Is it suitable for high-throughput screening?
Yes, solution format ensures accuracy and reproducibility.
Related products
Doxorubicin Liposome Solution for scientific research
High-purity Doxorubicin Liposome Solution, factory-manufactured for in vitro molecular mechanism studies and biochemical pathway research. Supplied as a stable liposomal solution, ideal for laboratories requiring bulk, wholesale, or customized research-grade supply. Original price was: $10.00.$8.00Current price is: $8.00.Limertinib (ASK120067) 80mg — Laboratory Research Grade Chemical
Limertinib is a high-purity, irreversible small-molecule inhibitor that selectively targets mutant EGFR in vitro. Designed specifically for laboratory research, it is ideal for investigating signal transduction, kinase activity, and receptor molecular mechanisms in cell-free or in vitro systems. This compound is suitable for mechanistic studies, target validation, and enzymatic assays. Original price was: $3.00.$2.00Current price is: $2.00.Elranatamab 76mg solution — Laboratory Research Grade Reagent
Elranatamab is a high-purity bispecific monoclonal antibody designed for in vitro studies of target engagement, molecular signaling, and cellular interaction mechanisms. It is intended exclusively for laboratory research, enabling precise mechanistic investigations in controlled experimental systems.
Original price was: $6.00.$3.00Current price is: $3.00.Fulvestrant (Faslodex) 250mg — Laboratory Research Grade Reagent
Fulvestrant (Faslodex) is a high-purity steroidal compound for in vitro molecular mechanism studies, including nuclear receptor binding, transcriptional modulation, and protein interaction research. It is intended exclusively for laboratory research and mechanistic investigations, enabling controlled experimental analysis in biochemical and cellular assays. Original price was: $6.00.$2.00Current price is: $2.00.
Reviews
There are no reviews yet.