Description

Product Description

Palmitoyl hexapeptide-12 is a synthetic bioactive peptide designed to mimic the behavior of natural skin matrix components, particularly elastin and collagen. It is part of the palmitoyl-linked peptide family known for their ability to penetrate the epidermis and influence dermal remodeling at a molecular level. This compound combines a lipophilic palmitoyl chain with a hexapeptide backbone to optimize both membrane permeability and receptor interaction, making it an ideal model for studying skin regeneration, elasticity, and anti-aging mechanisms.

At the molecular level, Palmitoyl hexapeptide-12 exerts dual biological functions: anti-inflammatory modulation and extracellular matrix stimulation. It reduces the pro-inflammatory cytokine interleukin-6 (IL-6), which plays a central role in photoaging and chronic skin inflammation. Elevated IL-6 levels are associated with collagen degradation and elastin fragmentation. By downregulating IL-6, Palmitoyl hexapeptide-12 helps maintain a favorable environment for fibroblast activity and matrix synthesis.

This peptide is also known to stimulate the production of collagen and fibronectin in dermal fibroblasts. It serves as a signal peptide that mimics the natural binding domains of ECM proteins, thereby activating integrin receptors and promoting fibroblast proliferation. Through this mechanism, Palmitoyl hexapeptide-12 contributes to the restoration of dermal structure, improved skin firmness, and reduced wrinkle depth in laboratory studies.

In research models, this compound is recognized for enhancing skin repair after UV exposure, mitigating oxidative stress, and supporting the recovery of the dermal extracellular matrix (ECM). The peptide acts synergistically with antioxidant pathways, contributing to reduced reactive oxygen species (ROS) levels and improved mitochondrial stability within dermal fibroblasts.

Because of its lipid-modified structure, Palmitoyl hexapeptide-12 penetrates the stratum corneum efficiently, enabling it to interact with target cells in deeper layers of the skin. This makes it an excellent model for studying cosmetic delivery mechanisms, dermal peptide diffusion, and receptor-mediated matrix remodeling.

In cosmetic peptide research, Palmitoyl hexapeptide-12 has been compared to natural elastin-derived peptides that regulate tissue regeneration and elasticity. It reproduces key biological messages of matrix proteins that signal fibroblasts to produce more structural components, thereby helping scientists understand molecular pathways related to anti-aging, skin firmness, and wrinkle reduction.

Moreover, Palmitoyl hexapeptide-12 supports angiogenic balance and helps maintain proper nutrient and oxygen exchange within the dermal microenvironment. The peptide’s unique structure (palmitoyl-Lys-Val-Lys-Lys-Thr-Gln) reflects a targeted biomimetic design to emulate natural skin renewal mechanisms.

Its ability to modulate inflammatory cytokines, combined with fibroblast activation and antioxidant properties, positions Palmitoyl hexapeptide-12 as a valuable molecule for photoaging, oxidative stress, and collagen metabolism research. These functions are particularly relevant in studying how peptides can promote the rejuvenation of aged or environmentally stressed skin at the molecular level.

Product Specifications

Mechanism of Action

Palmitoyl hexapeptide-12 acts as a signal peptide that binds to fibroblast receptors to promote the synthesis of collagen and extracellular matrix proteins. It mimics the natural sequence found in elastin and fibronectin fragments, which act as messengers to trigger tissue renewal.

When applied in in vitro models, the peptide stimulates fibroblast proliferation and upregulates the transcription of collagen I, III, and IV genes, leading to enhanced structural protein synthesis. It also promotes fibronectin expression, a glycoprotein essential for cell adhesion and matrix integrity.

On the inflammatory axis, Palmitoyl hexapeptide-12 significantly reduces IL-6 secretion, thereby mitigating chronic inflammation linked to oxidative damage and photoaging. By lowering IL-6 levels, it prevents the degradation of collagen fibers and maintains the skin’s mechanical strength.

Additionally, the peptide activates integrin β1 and TGF-β signaling pathways, both crucial in dermal matrix remodeling. Through these interactions, fibroblasts increase their biosynthetic activity, while matrix metalloproteinases (MMPs) are downregulated, leading to improved ECM stability.

In UV-exposure models, Palmitoyl hexapeptide-12 exhibits antioxidant and protective effects by counteracting ROS accumulation. It promotes the expression of enzymes such as superoxide dismutase (SOD) and catalase, enhancing the cell’s natural defense system against oxidative insults.

This comprehensive mechanism—spanning anti-inflammatory, antioxidant, and ECM-restorative effects—makes Palmitoyl hexapeptide-12 a valuable research peptide in the study of photoaging, wrinkle formation, and peptide-based anti-aging formulations.

Side Effects

Palmitoyl hexapeptide-12 demonstrates an excellent safety profile in in vitro studies. It is non-cytotoxic at experimental concentrations and does not interfere with normal fibroblast growth. Since it is designed for laboratory use, it must not be used in human or animal applications. Appropriate laboratory safety practices, including handling under sterile, controlled environments, should be observed.

Keywords

Palmitoyl hexapeptide-12; Biopeptide EL; anti-aging peptide; collagen synthesis; IL-6 reduction; fibroblast activation; photoaging research; extracellular matrix regeneration; wrinkle reduction; cosmetic peptide.

Shipping Guarantee

All shipments are handled using validated cold-chain logistics to preserve peptide integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage.

Trade Assurance

We ensure product authenticity, verified ≥99% purity, and compliance with analytical standards (HPLC, MS, and NMR). Each batch is supplied with a Certificate of Analysis (CoA). Our trade assurance policy guarantees replacement or refund for any deviation from listed specifications.

Payment Support

We provide flexible and secure global payment options to support international research transactions. Accepted payment methods include PayPal, major credit cards (Visa, MasterCard, American Express), telegraphic transfer (T/T), and cryptocurrencies (USDT, Bitcoin, Ethereum). All transactions are protected by industry-standard encryption and verified payment gateways to ensure confidentiality and fund security.

Disclaimer

All products listed are intended for laboratory research use only and not for human or veterinary use. They are not drugs, medical devices, or diagnostics and should not be administered to humans or animals. Researchers must handle all materials in accordance with institutional biosafety and chemical safety guidelines. The information provided is for scientific reference only and does not imply therapeutic efficacy, safety, or regulatory approval.