Description

Product Description

Palmitoyl hexapeptide-14 is a synthetically designed lipidated peptide that combines a short hexapeptide sequence with a palmitoyl moiety, improving its transdermal penetration and stability. This structural design allows the peptide to interact effectively with skin cells, including keratinocytes, fibroblasts, and sensory neurons, providing a multifaceted approach to skin research focused on inflammation modulation, barrier reinforcement, and cellular homeostasis.

The peptide mimics natural extracellular matrix signaling molecules, functioning as a matrikine-like compound that communicates with fibroblasts to upregulate collagen synthesis and maintain dermal matrix integrity. By enhancing fibroblast activity, Palmitoyl hexapeptide-14 supports the production of type I and type III collagen, fibronectin, and hyaluronic acid—critical components of the skin’s structural and functional framework.

Palmitoyl hexapeptide-14 also demonstrates potent anti-inflammatory effects by downregulating pro-inflammatory cytokines such as IL-6, TNF-α, and COX-2, as well as suppressing overactive NF-κB signaling pathways. These actions contribute to reduced cellular stress responses and help maintain the homeostasis of immune-modulatory mechanisms within the skin.

Furthermore, this peptide has been studied for its neuro-modulatory functions. By influencing neuropeptide release, including substance P and calcitonin gene-related peptide (CGRP), Palmitoyl hexapeptide-14 can reduce neurogenic inflammation, which is often associated with redness, irritation, and sensitive skin conditions. These mechanisms make it an important research compound for exploring the interplay between immune signaling and nervous system-mediated skin responses.

The palmitoyl moiety enhances the peptide’s lipophilicity, enabling more effective penetration into the stratum corneum and interaction with lipid membranes of epidermal cells. This feature improves its stability and bioavailability in in vitro and ex vivo studies. The peptide is compatible with a wide range of cosmetic formulation systems, including serums, emulsions, and liposomal delivery vehicles, making it highly versatile for laboratory research applications.

Palmitoyl hexapeptide-14 has also been linked to antioxidative activity, as it can mitigate oxidative stress within dermal fibroblasts, reducing the production of reactive oxygen species (ROS) and supporting mitochondrial function. By decreasing oxidative damage and inflammatory signaling simultaneously, the peptide contributes to overall cellular longevity and barrier resilience.

Overall, Palmitoyl hexapeptide-14 is a multifunctional peptide of high interest in cosmetic research. Its dual focus on inflammation control and barrier restoration, combined with neuropeptide modulation, positions it as a key molecule for studying redness reduction, immune regulation, dermal matrix repair, and anti-aging pathways in laboratory settings.

Product Specifications

Mechanism of Action

Palmitoyl hexapeptide-14 primarily functions as a matrikine-like signaling peptide, modulating fibroblast and keratinocyte activity to support skin barrier function and extracellular matrix repair. Its palmitoyl group facilitates transdermal delivery and interaction with epidermal lipid layers, enhancing its efficacy in research applications.

1. Anti-Inflammatory Pathway
The peptide downregulates key pro-inflammatory mediators, including IL-6, TNF-α, and COX-2. By inhibiting NF-κB signaling, Palmitoyl hexapeptide-14 mitigates chronic inflammatory responses and maintains cellular immune homeostasis.

2. Neuro-Immune Modulation
Palmitoyl hexapeptide-14 reduces neurogenic inflammation by regulating the release of neuropeptides such as substance P and CGRP, which are implicated in redness, irritation, and barrier dysfunction. This mechanism links nervous system signaling with skin immune responses.

3. Dermal Matrix Repair
The peptide stimulates fibroblast synthesis of collagen types I and III, fibronectin, and hyaluronic acid, promoting structural integrity and elasticity. It also inhibits MMP activity to prevent extracellular matrix degradation, supporting long-term barrier function.

4. Skin Barrier Enhancement
By reinforcing intercellular lipid structures and enhancing keratinocyte function, the peptide improves epidermal cohesion, reduces transepidermal water loss (TEWL), and strengthens the skin’s physical barrier against environmental stressors.

5. Oxidative Stress Mitigation
Palmitoyl hexapeptide-14 supports endogenous antioxidant systems, lowering ROS levels and protecting fibroblast mitochondria from oxidative damage, thereby preserving cellular function and prolonging viability.

Side Effects

Palmitoyl hexapeptide-14 demonstrates excellent biocompatibility in vitro, showing minimal cytotoxicity or irritation at standard research concentrations. Studies on human dermal fibroblasts and keratinocytes indicate no significant activation of pro-inflammatory markers when used within recommended experimental ranges.

Potential side effects are rare and generally linked to improper storage or excessive concentrations. The peptide should be stored at 2–8 °C, protected from light and moisture to maintain stability and bioactivity.

As this compound is strictly for laboratory research, it is not intended for direct human or animal use. Researchers should follow standard biosafety protocols when handling or formulating this peptide.

Keywords

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Shipping Guarantee

All shipments are handled using validated cold-chain logistics to preserve peptide integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage.

Trade Assurance

We ensure product authenticity, verified ≥99% purity, and compliance with analytical standards (HPLC, MS, and NMR). Each batch is supplied with a Certificate of Analysis (CoA). Our trade assurance policy guarantees replacement or refund for any deviation from listed specifications.

Payment Support

We provide flexible and secure global payment options to support international research transactions. Accepted payment methods include PayPal, major credit cards (Visa, MasterCard, American Express), telegraphic transfer (T/T), and cryptocurrencies (USDT, Bitcoin, Ethereum). All transactions are protected by industry-standard encryption and verified payment gateways to ensure confidentiality and fund security.

Disclaimer

All products listed are intended for laboratory research use only and not for human or veterinary use. They are not drugs, medical devices, or diagnostics and should not be administered to humans or animals. Researchers must handle all materials in accordance with institutional biosafety and chemical safety guidelines. The information provided is for scientific reference only and does not imply therapeutic efficacy, safety, or regulatory approval.