Palmitoyl pentapeptide-4 | CAS 214047-00-4 | Anti-Aging Cosmetic Peptide for Skin Regeneration and Wrinkle Reduction Research

Description

Product Description

Palmitoyl pentapeptide-4, commonly referred to as Matrixyl, is a synthetic pentapeptide conjugated with palmitic acid that enhances skin permeability and bioactivity. Its molecular structure allows for optimal dermal penetration, making it a preferred ingredient in cosmetic research aimed at reducing fine lines and stimulating collagen synthesis. As a bioactive peptide, it mimics fragments of endogenous extracellular matrix proteins, particularly those involved in tissue repair and structural integrity.

In cosmetic peptide research, Palmitoyl pentapeptide-4 has demonstrated the ability to stimulate fibroblast activity, increasing the synthesis of collagen types I and III, as well as elastin and glycosaminoglycans. These effects improve skin elasticity, firmness, and hydration, thereby reducing the appearance of wrinkles and fine lines. Its incorporation into topical formulations has been widely studied for dermal regeneration and anti-aging applications, often in combination with other antioxidants and peptide complexes.

Mechanistically, Palmitoyl pentapeptide-4 interacts with cell surface receptors on fibroblasts, triggering signaling pathways that enhance extracellular matrix production. This peptide modulates gene expression related to collagen formation, matrix metalloproteinase activity, and tissue remodeling. Its anti-aging effects are attributed not only to structural protein stimulation but also to the prevention of collagen degradation, maintaining skin resilience and thickness over time.

Palmitoyl pentapeptide-4 is highly compatible with cosmetic research due to its low molecular weight, high solubility in aqueous formulations, and excellent skin tolerance. Studies indicate minimal cytotoxicity and immunogenicity, making it suitable for a wide range of in vitro and ex vivo dermatological experiments. Researchers often employ it to evaluate the efficacy of anti-wrinkle peptides, cosmetic delivery systems, and combined antioxidant formulations.

In addition to its primary anti-aging and collagen-stimulating activities, Palmitoyl pentapeptide-4 has shown synergistic effects with other bioactive peptides and vitamins. These combinations enhance cellular repair, dermal hydration, and oxidative stress mitigation, providing a comprehensive approach to skin rejuvenation and pigment protection. The peptide also serves as a model compound in studies of dermal remodeling, wrinkle reduction, and cosmetic peptide mechanism of action.

Its structure-activity relationship indicates that the palmitoyl moiety improves lipophilicity and membrane penetration, allowing deeper interaction with dermal fibroblasts. This attribute is particularly important in research exploring topical delivery systems, liposomal carriers, and transdermal absorption of cosmetic peptides.

Overall, Palmitoyl pentapeptide-4 represents a well-characterized, potent, and biocompatible anti-aging peptide. It remains a central molecule in cosmetic peptide research focused on collagen stimulation, skin regeneration, wrinkle reduction, and overall dermal rejuvenation.

Product Specifications

Mechanism of Action

Palmitoyl pentapeptide-4 acts by stimulating fibroblast activity, which leads to increased production of extracellular matrix proteins such as collagen, elastin, and glycosaminoglycans. This enhances dermal elasticity, skin firmness, and hydration, effectively reducing the appearance of wrinkles and fine lines.

Mechanistic highlights:

1. Collagen Stimulation: Increases synthesis of collagen types I and III.

2. Elastin Production: Enhances skin elasticity and structural integrity.

3. Extracellular Matrix Remodeling: Regulates matrix metalloproteinase activity to prevent collagen degradation.

4. Enhanced Dermal Penetration: The palmitoyl group facilitates lipid membrane permeability for deeper skin interaction.

5. Synergistic Effects: Works with antioxidants and other peptides to improve skin repair, hydration, and anti-aging outcomes.

   

Side Effects

Palmitoyl pentapeptide-4 demonstrates excellent skin tolerance and minimal cytotoxicity in vitro. It is non-immunogenic and highly compatible with cosmetic research models. Standard laboratory precautions should be followed, including protection from moisture and light during storage. It is not intended for human or veterinary use.

Keywords

Palmitoyl pentapeptide-4, Matrixyl, anti-aging peptide, collagen synthesis, wrinkle reduction, dermal regeneration, cosmetic peptide research, skin rejuvenation, anti-wrinkle peptide, peptide skincare

Shipping Guarantee

All shipments are handled using validated cold-chain logistics to preserve peptide integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage.

Trade Assurance

We ensure product authenticity, verified ≥99% purity, and compliance with analytical standards (HPLC, MS, and NMR). Each batch is supplied with a Certificate of Analysis (CoA). Our trade assurance policy guarantees replacement or refund for any deviation from listed specifications.

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Disclaimer

All products listed are intended for laboratory research use only and not for human or veterinary use. They are not drugs, medical devices, or diagnostics and should not be administered to humans or animals. Researchers must handle all materials in accordance with institutional biosafety and chemical safety guidelines. The information provided is for scientific reference only and does not imply therapeutic efficacy, safety, or regulatory approval.