Description

Product Description

Palmitoyl tetrapeptide-10 (CAS 887140-79-6) is a synthetic biomimetic peptide that has gained increasing attention in cosmetic peptide research for its ability to reinforce the skin barrier, enhance keratinocyte differentiation, and improve the overall health of sensitive skin. This lipopeptide combines a bioactive tetrapeptide sequence with a palmitoyl fatty acid chain that allows deeper penetration through the stratum corneum and stable integration within skin cell membranes. Through this amphiphilic nature, Palmitoyl tetrapeptide-10 achieves both bioavailability and long-lasting skin-repair activity, making it a valuable component for laboratory studies in the field of anti-aging and skin barrier restoration.

In research environments, Palmitoyl tetrapeptide-10 is often explored for its ability to promote corneodesmosin and filaggrin synthesis—two critical proteins responsible for the cohesion and hydration of the epidermis. By enhancing these structural elements, the peptide strengthens the skin’s natural defense system, helping it better resist environmental aggressors such as pollution, UV radiation, and oxidative stress. Sensitive skin models treated with Palmitoyl tetrapeptide-10 show visible improvements in resilience, texture uniformity, and tolerance thresholds, which are indicators of restored epidermal integrity.

Furthermore, Palmitoyl tetrapeptide-10 contributes to cellular communication between the dermis and epidermis, facilitating cross-talk that regulates differentiation and renewal. This communication is essential for maintaining homeostasis in skin exposed to repeated irritation, mechanical stress, or overexposure to cosmetic actives. As a lipid-conjugated peptide, it integrates seamlessly into phospholipid membranes, enhancing transport efficiency and prolonging its bioactivity in skin models.

In cosmetic peptide research, Palmitoyl tetrapeptide-10 is often studied as part of anti-aging peptide complexes, where it complements collagen-stimulating peptides such as Palmitoyl tripeptide-1 or Palmitoyl tetrapeptide-7. Together, they create synergistic activity, promoting elasticity, firmness, and smoother skin appearance. Palmitoyl tetrapeptide-10 specifically targets barrier recovery, offering benefits in sensitive-skin formulations and post-procedural repair solutions.

Laboratory research demonstrates that Palmitoyl tetrapeptide-10 activates genes related to epidermal cohesion, particularly those involved in corneocyte adhesion and keratinocyte terminal differentiation. These processes ensure the stratum corneum remains intact and capable of retaining optimal moisture. Additionally, it helps mitigate the effects of pro-inflammatory cytokines such as IL-6 and TNF-α, which often contribute to sensitivity and redness. This anti-inflammatory property supports its inclusion in experimental soothing and barrier-repair formulations.

From a molecular perspective, Palmitoyl tetrapeptide-10 enhances lipid synthesis within the skin, supporting ceramide and sphingolipid production, both essential for preventing transepidermal water loss (TEWL). Its antioxidant capacity also protects cellular components from oxidative degradation, a fundamental factor in delaying signs of premature aging.

The peptide’s multifaceted mechanism—spanning barrier enhancement, anti-inflammatory modulation, and hydration support—positions Palmitoyl tetrapeptide-10 as a highly relevant molecule in modern dermatological and cosmetic peptide studies. Researchers investigating sensitive skin, pigmentation irregularities, and epidermal renewal rely on this peptide as a reference compound for developing advanced skin-repair formulations.

Product Specifications

Mechanism of Action

The biological mechanism of Palmitoyl tetrapeptide-10 involves targeted enhancement of epidermal cohesion and restoration of the stratum corneum’s defensive architecture. The peptide achieves this by activating specific genes responsible for keratinocyte differentiation and desmosomal junction formation, including those coding for corneodesmosin and filaggrin.

1. Stimulation of Filaggrin Production
   Filaggrin is a vital epidermal protein that binds keratin filaments together, providing skin strength and structure. Palmitoyl tetrapeptide-10 upregulates filaggrin gene expression, reinforcing the barrier and improving water retention. This enhances the natural moisturizing factor (NMF) levels in the epidermis, restoring hydration and smoothness.

2. Enhancement of Corneodesmosin Synthesis
   Corneodesmosin contributes to cell-cell adhesion in the stratum corneum. Palmitoyl tetrapeptide-10 promotes its synthesis, improving cohesion between corneocytes and reducing barrier permeability. This leads to smoother texture and protection against irritants.

3. Anti-Inflammatory and Antioxidant Modulation
   The peptide downregulates pro-inflammatory cytokines and protects cells from oxidative stress. Its antioxidant potential reduces ROS accumulation, safeguarding lipids and proteins from degradation.

4. Regulation of Pigmentation
   Palmitoyl tetrapeptide-10 indirectly influences melanocyte behavior by stabilizing the epidermal microenvironment. Through homeostatic regulation, it prevents hyperactivation of melanogenesis pathways, leading to even skin tone.

5. Lipid Metabolism Support
   The palmitoyl modification enhances lipid affinity, promoting ceramide synthesis and maintaining healthy lipid layers in the stratum corneum. This process ensures low TEWL and prevents dryness or sensitivity.

In cosmetic peptide research, Palmitoyl tetrapeptide-10 demonstrates significant synergy with other peptides such as Palmitoyl tripeptide-1, Palmitoyl tetrapeptide-7, and Acetyl hexapeptide-8. When combined, these molecules enhance the structural regeneration of the dermis and epidermis, resulting in greater skin elasticity and barrier integrity.

Side Effects

In controlled laboratory research, Palmitoyl tetrapeptide-10 exhibits a high safety margin with no known toxic or sensitizing effects. It is non-irritating and well-tolerated in reconstructed human epidermis models. Some in vitro studies indicate that excessive concentrations may cause temporary stress responses in sensitive cell lines, though these are reversible upon dilution.

Researchers should ensure sterile techniques and avoid cross-contamination. Peptide degradation can occur under exposure to heat, humidity, or light; thus, storage at –20°C in desiccated vials is recommended. The product is not intended for human or animal administration and must be used for laboratory purposes only.

Keywords

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Shipping Guarantee

All shipments are handled using validated cold-chain logistics to preserve peptide integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage.

Trade Assurance

We ensure product authenticity, verified ≥99% purity, and compliance with analytical standards (HPLC, MS, and NMR). Each batch is supplied with a Certificate of Analysis (CoA). Our trade assurance policy guarantees replacement or refund for any deviation from listed specifications.

Payment Support

We provide flexible and secure global payment options to support international research transactions. Accepted payment methods include PayPal, major credit cards (Visa, MasterCard, American Express), telegraphic transfer (T/T), and cryptocurrencies (USDT, Bitcoin, Ethereum). All transactions are protected by industry-standard encryption and verified payment gateways to ensure confidentiality and fund security.

Disclaimer

All products listed are intended for laboratory research use only and not for human or veterinary use. They are not drugs, medical devices, or diagnostics and should not be administered to humans or animals. Researchers must handle all materials in accordance with institutional biosafety and chemical safety guidelines. The information provided is for scientific reference only and does not imply therapeutic efficacy, safety, or regulatory approval.