Description

Product Description

Palmitoyl Tetrapeptide-3 is a synthetic tetrapeptide derived from amino acids 341-344 of the human immunoglobulin heavy chain. The peptide has been specifically engineered for cosmetic research applications, targeting skin aging, inflammation, and wrinkle formation in laboratory studies. Its design enables potent interaction with dermal fibroblasts and keratinocytes, promoting regenerative processes that improve skin texture, elasticity, and overall resilience.

Laboratory research has shown that Palmitoyl Tetrapeptide-3 effectively reduces the secretion of interleukin-6 (IL-6) in keratinocytes, a cytokine known to contribute to chronic skin inflammation and photoaging. By inhibiting IL-6 production, this peptide mitigates inflammatory responses induced by environmental stressors such as UVB radiation, which are major contributors to premature skin aging, wrinkle formation, and loss of elasticity.

In addition to its anti-inflammatory activity, Palmitoyl Tetrapeptide-3 promotes extracellular matrix (ECM) regeneration. Experimental models demonstrate increased synthesis of collagen, elastin, and proteoglycans, which are essential components of dermal architecture. This activity contributes to a measurable reduction in fine lines and wrinkles in in vitro and ex vivo skin models. The peptide also stimulates elastic fiber production in the papillary dermis, which enhances skin firmness and resilience, further supporting anti-aging outcomes.

Palmitoyl Tetrapeptide-3 is soluble in aqueous buffers, allowing convenient incorporation into research formulations such as serums, creams, hydrogels, and other cosmetic delivery systems. Researchers often investigate its synergistic potential with other bioactive peptides like Palmitoyl Tetrapeptide-7, Acetyl Hexapeptide-8, and antioxidant molecules including L-Glutathione and Vitamin C derivatives to evaluate enhanced anti-aging effects.

Mechanistically, Palmitoyl Tetrapeptide-3 modulates cellular signaling pathways related to inflammation and skin regeneration. By inhibiting IL-6 and other pro-inflammatory cytokines, it reduces dermal matrix degradation. The peptide simultaneously stimulates fibroblast proliferation and activity, promoting collagen and elastin deposition, which contributes to wrinkle reduction, improved skin elasticity, and dermal rejuvenation in experimental models.

Its bioactive properties, combined with high stability in laboratory conditions, make Palmitoyl Tetrapeptide-3 a valuable research tool for investigating skin aging, wrinkle prevention, and peptide-based cosmetic interventions. Its dual activity—anti-inflammatory and extracellular matrix promotion—provides a comprehensive approach for studying peptide-mediated dermal rejuvenation.

Product Specifications

Mechanism of Action

Palmitoyl Tetrapeptide-3 exerts its effects through two primary mechanisms: inhibition of inflammatory cytokine secretion and stimulation of extracellular matrix regeneration.

1. Anti-inflammatory pathway: The peptide reduces IL-6 secretion in keratinocytes and modulates other pro-inflammatory mediators triggered by environmental stressors, including UVB radiation. Reduced cytokine activity mitigates dermal inflammation, a major factor in premature skin aging and wrinkle formation.

2. Dermal matrix promotion: Palmitoyl Tetrapeptide-3 stimulates fibroblast proliferation and promotes synthesis of collagen, elastin, and proteoglycans. Enhanced extracellular matrix deposition improves skin elasticity, structural integrity, and overall appearance in experimental models.

In combination with other bioactive peptides and antioxidants, Palmitoyl Tetrapeptide-3 exhibits synergistic anti-aging effects. Its small molecular size allows penetration into the dermis, ensuring effective interaction with target cells and signaling pathways. Laboratory studies have confirmed its role in reducing wrinkle depth, improving skin firmness, and supporting skin rejuvenation in peptide-based cosmetic research.

Side Effects

Palmitoyl Tetrapeptide-3 demonstrates excellent tolerability in laboratory models. Key points include:

• Concentration considerations: Optimal dosing is recommended to maintain cell viability in vitro.

• Formulation factors: Buffer pH and co-ingredients can influence stability but generally maintain peptide bioactivity.

• Handling precautions: For laboratory research only. Use personal protective equipment, avoid ingestion, inhalation, or eye contact.

• Storage requirements: Store at -20°C, protected from light and moisture.

No systemic toxicity or severe adverse effects have been reported in preclinical experiments, making it safe for cosmetic peptide research.

Keywords

Palmitoyl Tetrapeptide-3, anti-aging peptide, cosmetic peptide, skin wrinkle reduction, extracellular matrix peptide, peptide supplier China, high-purity cosmetic peptides, peptide wholesale, factory peptide supplier, cosmetic raw material manufacturer.

Shipping Guarantee

All shipments are handled using validated cold-chain logistics to preserve peptide integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage.

Trade Assurance

We ensure product authenticity, verified ≥99% purity, and compliance with analytical standards (HPLC, MS, and NMR). Each batch is supplied with a Certificate of Analysis (CoA). Our trade assurance policy guarantees replacement or refund for any deviation from listed specifications.

Payment Support

We provide flexible and secure global payment options to support international research transactions. Accepted payment methods include PayPal, major credit cards (Visa, MasterCard, American Express), telegraphic transfer (T/T), and cryptocurrencies (USDT, Bitcoin, Ethereum). All transactions are protected by industry-standard encryption and verified payment gateways to ensure confidentiality and fund security.

Disclaimer

All products listed are intended for laboratory research use only and not for human or veterinary use. They are not drugs, medical devices, or diagnostics and should not be administered to humans or animals. Researchers must handle all materials in accordance with institutional biosafety and chemical safety guidelines. The information provided is for scientific reference only and does not imply therapeutic efficacy, safety, or regulatory approval.