Description

Product Description

Palmitoyl tripeptide-1 is a fatty acid–modified signal peptide consisting of a short amino acid sequence linked to a palmitoyl group, enhancing its skin permeability and biological activity. This peptide belongs to a family of matrikines—short fragments derived from extracellular matrix (ECM) proteins—that act as cell messengers to regulate tissue repair and renewal.

In cosmetic research, Palmitoyl tripeptide-1 (also known as palmitoyl oligopeptide) has become one of the most studied anti-aging ingredients due to its proven ability to stimulate collagen, elastin, and glycosaminoglycan synthesis in fibroblast cells. These activities contribute to visible improvements in skin tone, elasticity, and firmness—core parameters associated with youthful and healthy-looking skin.

The palmitoyl modification significantly improves peptide bioavailability and lipophilicity, allowing it to penetrate the stratum corneum efficiently. Once absorbed, the peptide interacts with cell surface receptors in the dermis, initiating a cascade of regenerative signals that mimic the skin’s natural wound-healing and remodeling processes.

Research shows that Palmitoyl tripeptide-1 increases the expression of genes associated with collagen I, III, and IV synthesis. It strengthens the dermal-epidermal junction (DEJ) and enhances extracellular matrix density, effectively reducing wrinkle depth and surface roughness. Combined with other matrix-stimulating peptides like Palmitoyl tetrapeptide-7, it forms the well-known Matrixyl® complex, a benchmark in anti-aging peptide science.

In vitro and ex vivo studies have demonstrated that consistent application of Palmitoyl tripeptide-1 increases skin elasticity by up to 20% and improves dermal smoothness within a few weeks of peptide exposure in cosmetic research formulations. Its biocompatibility and stability make it ideal for laboratory investigation of peptide-based skin rejuvenation mechanisms.

Beyond wrinkle reduction, Palmitoyl tripeptide-1 contributes to skin barrier restoration, reducing transepidermal water loss (TEWL) and improving skin hydration. It helps restore structural proteins affected by oxidative stress, ultraviolet radiation, and chronological aging, offering a holistic approach to skin regeneration studies.

Overall, Palmitoyl tripeptide-1 serves as a potent, multifunctional peptide model for exploring anti-aging mechanisms, collagen metabolism, and biomimetic repair processes in cosmetic science.

Product Specifications

Mechanism of Action

Palmitoyl tripeptide-1 functions as a matrikine—a small peptide that mimics natural ECM degradation fragments responsible for cell communication and tissue regeneration. Its biological activity is enhanced by the lipophilic palmitoyl chain, which improves cell membrane interaction and dermal penetration.

1. Activation of Collagen Production

The peptide binds to fibroblast receptors, stimulating the TGF-β/SMAD signaling pathway and promoting collagen types I and III synthesis. This action restores skin structural integrity and reduces wrinkle formation.

2. Reinforcement of Dermal-epidermal Junction (DEJ)

By upregulating laminin-5 and integrin expression, Palmitoyl tripeptide-1 enhances dermal-epidermal cohesion, improving skin firmness and resilience.

3. Matrix Remodeling and Anti-wrinkle Effect

It regulates matrix metalloproteinase (MMP) activity, preventing collagen breakdown and supporting ECM balance. This mechanism visibly smooths fine lines and improves skin density.

4. Barrier Function and Hydration

The peptide enhances ceramide synthesis and lipid metabolism in keratinocytes, helping reduce transepidermal water loss and improving hydration levels.

5. Synergistic Effect with Other Peptides

In combination with Palmitoyl tetrapeptide-7, Palmitoyl tripeptide-1 demonstrates synergistic anti-aging benefits, amplifying collagen regeneration and reducing inflammation in cosmetic research models.

Side Effects

Palmitoyl tripeptide-1 is widely recognized as a low-irritation, biocompatible peptide suitable for cosmetic research. Mild transient erythema may occur at high test concentrations but resolves without lasting effects.
It is non-toxic, non-mutagenic, and safe for long-term laboratory testing under controlled research conditions.

Keywords

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Shipping Guarantee

All shipments are handled using validated cold-chain logistics to preserve peptide integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage.

Trade Assurance

We ensure product authenticity, verified ≥99% purity, and compliance with analytical standards (HPLC, MS, and NMR). Each batch is supplied with a Certificate of Analysis (CoA). Our trade assurance policy guarantees replacement or refund for any deviation from listed specifications.

Payment Support

We provide flexible and secure global payment options to support international research transactions. Accepted payment methods include PayPal, major credit cards (Visa, MasterCard, American Express), telegraphic transfer (T/T), and cryptocurrencies (USDT, Bitcoin, Ethereum). All transactions are protected by industry-standard encryption and verified payment gateways to ensure confidentiality and fund security.

Disclaimer

All products listed are intended for laboratory research use only and not for human or veterinary use. They are not drugs, medical devices, or diagnostics and should not be administered to humans or animals. Researchers must handle all materials in accordance with institutional biosafety and chemical safety guidelines. The information provided is for scientific reference only and does not imply therapeutic efficacy, safety, or regulatory approval.