Description

Product Description

Palmitoyl Tripeptide-1 Hydrochloride (CAS 2757690-14-3) is a synthetic bioactive peptide composed of a tripeptide linked to palmitic acid, enhancing lipophilicity and transdermal penetration. As a signal peptide derivative, it functions as a key regulator in the communication between dermal and epidermal cells, stimulating fibroblast activity to increase the synthesis of collagen, fibronectin, and other extracellular matrix components. This property makes it one of the most extensively studied peptides in cosmetic and dermatological research focused on anti-wrinkle, firming, and skin repair formulations.

This compound mimics the natural sequence of the collagen fragment GHK (Gly-His-Lys), sending “repair messages” to aging or damaged skin cells. Through its fatty acid modification, Palmitoyl Tripeptide-1 Hydrochloride can efficiently penetrate the skin barrier, ensuring deeper biological activity and improved stability in both aqueous and lipid-based formulations. The hydrochloride salt form increases its solubility and chemical stability, making it suitable for a wide range of laboratory applications including peptide delivery system testing and dermal matrix regeneration studies.

At the molecular level, Palmitoyl Tripeptide-1 Hydrochloride binds to specific fibroblast receptors and activates gene expression associated with collagen I, III, and IV synthesis. It enhances dermal-epidermal junction strength and improves elasticity by promoting fibrillin and laminin production. In vitro studies have shown significant improvement in dermal density and reduction of fine lines after consistent use in cosmetic peptide formulations. The peptide’s mechanism involves upregulation of transforming growth factor-beta (TGF-β), which plays a crucial role in cell proliferation, differentiation, and extracellular matrix reconstruction.

In combination with other peptides such as Palmitoyl Tetrapeptide-7, this compound forms the well-known “Matrixyl” complex, which has been demonstrated to synergistically improve wrinkle reduction and skin smoothness. Research also indicates its potential role in accelerating wound repair and enhancing tissue regeneration, making it valuable for broader applications in dermatological biochemistry and anti-aging peptide studies.

Due to its unique amphiphilic structure, Palmitoyl Tripeptide-1 Hydrochloride can integrate easily into lipid membranes, increasing its bioavailability and interaction with dermal cell receptors. Its safety profile in research environments is favorable, with no reported cytotoxicity at typical experimental concentrations. The peptide’s enhanced delivery and long-lasting activity continue to make it a focus of innovation in skin renewal and regenerative peptide technologies.

Product Specifications

Mechanism of Action

Palmitoyl Tripeptide-1 Hydrochloride acts as a signal peptide that mimics natural skin-repairing proteins. It binds to fibroblast receptors and triggers the expression of extracellular matrix genes responsible for collagen, elastin, and glycosaminoglycan synthesis. This activity enhances dermal density and elasticity while reducing wrinkle depth in controlled research environments.

The peptide’s palmitoyl modification allows it to integrate effectively into lipid membranes, facilitating deep skin penetration and stable peptide delivery. The hydrochloride form improves solubility and compatibility with both hydrophilic and lipophilic formulations, making it ideal for in vitro and ex vivo research systems.

Through stimulation of the TGF-β pathway, Palmitoyl Tripeptide-1 Hydrochloride increases fibroblast proliferation and extracellular matrix synthesis. The result is a measurable improvement in dermal firmness and skin resilience, supported by enhanced collagen crosslinking and matrix reorganization.

Side Effects

In laboratory conditions, Palmitoyl Tripeptide-1 Hydrochloride shows no significant cytotoxicity or irritation. It is stable under standard peptide storage and handling protocols. Researchers should avoid direct human or animal application and adhere to biosafety level-2 laboratory practices.

Keywords

Palmitoyl Tripeptide-1 Hydrochloride, CAS 2757690-14-3, anti-wrinkle peptide, collagen synthesis peptide, Matrixyl ingredient, cosmetic peptide supplier, OEM peptide production, peptide wholesale China, high-purity peptide factory, low-price peptide supplier

Shipping Guarantee

All Palmitoyl Tripeptide-1 Hydrochloride shipments are handled using validated cold-chain logistics to preserve peptide integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage.

Trade Assurance

We ensure Palmitoyl Tripeptide-1 Hydrochloride product authenticity, verified ≥99% purity, and compliance with analytical standards (HPLC, MS, and NMR). Each batch is supplied with a Certificate of Analysis (CoA). Our trade assurance policy guarantees replacement or refund for any deviation from listed specifications.

Payment Support

We Palmitoyl Tripeptide-1 Hydrochloride provide flexible and secure global payment options to support international research transactions. Accepted payment methods include PayPal, major credit cards (Visa, MasterCard, American Express), telegraphic transfer (T/T), and cryptocurrencies (USDT, Bitcoin, Ethereum). All transactions are protected by industry-standard encryption and verified payment gateways to ensure confidentiality and fund security.

Disclaimer

All Palmitoyl Tripeptide-1 Hydrochloride products listed are intended for laboratory research use only and not for human or veterinary use. They are not drugs, medical devices, or diagnostics and should not be administered to humans or animals. Researchers must handle all materials in accordance with institutional biosafety and chemical safety guidelines. The information provided is for scientific reference only and does not imply therapeutic efficacy, safety, or regulatory approval.