Description

Product Description

Pentapeptide-3 is a synthetic peptide inspired by waglerin-1, a neurotoxin found in the venom of the Temple Viper (Tropidolaemus wagleri). Designed to reproduce the peptide’s neuromuscular-blocking mechanism in a safe and reversible manner, Pentapeptide-3 represents a breakthrough in peptide-based anti-aging and cosmetic research.

Functionally, Pentapeptide-3 acts as a competitive antagonist of nicotinic acetylcholine receptors (nAChRs) located on the post-synaptic membranes of muscle fibers. By inhibiting the binding of acetylcholine, it reduces muscle fiber depolarization and subsequent contraction. This action leads to temporary muscle relaxation in targeted areas such as facial expression lines, effectively softening wrinkles and preventing their deepening with repeated use.

Unlike botulinum toxin (Botox), Pentapeptide-3 provides a non-invasive pathway to achieve a similar muscle-relaxing effect without the need for injections. It allows researchers to explore the modulation of neuromuscular signaling in a controlled and reversible environment, making it an essential molecule for developing next-generation anti-wrinkle formulations and neurocosmetic research models.

In laboratory and cosmetic peptide research, Pentapeptide-3 has shown to:

• Reduce the depth of expression wrinkles (such as crow’s feet and forehead lines) in in vitro skin models.

• Improve smoothness and elasticity by decreasing the frequency of facial muscle contractions.

• Support dermal matrix integrity through indirect fibroblast stimulation.

• Exhibit synergistic effects when combined with collagen-boosting peptides and moisturizing agents.

This peptide offers excellent stability and solubility under standard conditions, typically formulated into lyophilized powder form with a purity ≥99%. Pentapeptide-3 has been widely studied as a benchmark neuropeptide in the field of skin relaxation and anti-aging mechanisms, particularly in the context of peptide signaling and facial micro-muscular control.

As a cosmetic research peptide, Pentapeptide-3 is utilized in model systems for understanding the effects of neuromodulation on wrinkle formation. Researchers use it to examine peptide interactions with nAChR subtypes, downstream calcium flux inhibition, and skin barrier homeostasis improvement through controlled relaxation.

Its non-toxic and reversible inhibitory activity ensures safety in vitro while maintaining reproducibility across experiments. Combined with peptides such as acetyl hexapeptide-8 and palmitoyl tripeptide-5, Pentapeptide-3 enables synergistic testing of advanced anti-aging complexes targeting the dermal-epidermal junction.

Product Specifications

Mechanism of Action

Pentapeptide-3’s mechanism is based on mimicking the neuromuscular inhibition caused by waglerin-1, a peptide toxin that blocks muscle contraction. However, Pentapeptide-3 acts safely and reversibly, allowing detailed study of the neuromodulatory mechanisms in cosmetic and dermatological peptide research.

1. Competitive Antagonism of nAChRs

Pentapeptide-3 binds competitively to the α-subunit of nicotinic acetylcholine receptors located on skeletal muscle membranes. This binding prevents acetylcholine from activating the receptor, thereby inhibiting ion flow and halting depolarization. As a result, muscle fibers remain relaxed, reducing facial tension and expression-induced wrinkles.

2. Inhibition of Muscle Micro-Contractions

By modulating acetylcholine-mediated signaling, Pentapeptide-3 decreases micro-contractions in facial muscles. This helps to relax dynamic wrinkles, particularly in high-expression areas such as the forehead, eye corners, and nasolabial folds.

3. Cellular Communication and Homeostasis

Beyond its neuromuscular blocking activity, Pentapeptide-3 influences dermal cell signaling pathways, promoting a balanced environment for fibroblasts and keratinocytes. This supports skin elasticity, hydration, and long-term resilience.

4. Synergistic Anti-Aging Effects

When used in combination with peptides that enhance collagen synthesis (such as palmitoyl tetrapeptide-7 or tripeptide-1), Pentapeptide-3 exhibits complementary activity—relaxing facial muscles while reinforcing dermal structure. This dual mechanism results in smoother, firmer, and more youthful skin appearance in experimental models.

5. Safety and Reversibility

The binding of Pentapeptide-3 to nAChRs is reversible, distinguishing it from toxin-based mechanisms. It allows for repeated, controlled studies without lasting effects on receptor integrity or cell viability.

Side Effects

Pentapeptide-3 shows excellent safety and tolerance in in vitro skin research. It does not cause irritation, cytotoxicity, or lasting receptor damage. Its reversible mode of action ensures normal muscle activity resumes after removal. Researchers are advised to handle all peptide materials under sterile and controlled conditions, maintaining -20°C storage to preserve potency and stability.

Keywords

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Shipping Guarantee

All shipments are handled using validated cold-chain logistics to preserve peptide integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage.

Trade Assurance

We ensure product authenticity, verified ≥99% purity, and compliance with analytical standards (HPLC, MS, and NMR). Each batch is supplied with a Certificate of Analysis (CoA). Our trade assurance policy guarantees replacement or refund for any deviation from listed specifications.

Payment Support

We provide flexible and secure global payment options to support international research transactions. Accepted payment methods include PayPal, major credit cards (Visa, MasterCard, American Express), telegraphic transfer (T/T), and cryptocurrencies (USDT, Bitcoin, Ethereum). All transactions are protected by industry-standard encryption and verified payment gateways to ensure confidentiality and fund security.

Disclaimer

All products listed are intended for laboratory research use only and not for human or veterinary use. They are not drugs, medical devices, or diagnostics and should not be administered to humans or animals. Researchers must handle all materials in accordance with institutional biosafety and chemical safety guidelines. The information provided is for scientific reference only and does not imply therapeutic efficacy, safety, or regulatory approval.