Description

Product Description

Pentapeptide-31 is a synthetic bioactive peptide designed for cosmetic applications targeting skin aging. Structurally, it consists of a chain of five amino acids forming a short, stable peptide capable of penetrating the stratum corneum and interacting with dermal fibroblasts. Its primary function is to stimulate collagen synthesis, enhance elastin fiber production, and restore extracellular matrix integrity.

Mechanistic Insights: Pentapeptide-31 mimics signaling molecules involved in tissue repair, including TGF-β and fibroblast growth factor pathways. By binding to receptors on fibroblasts, Pentapeptide-31 activates intracellular cascades that lead to increased synthesis of structural proteins such as type I and III collagen, elastin, and glycosaminoglycans. This leads to visible improvements in skin elasticity, reduction in wrinkle depth, and enhanced dermal thickness.

Cellular Effects: In vitro studies demonstrate that Pentapeptide-31 increases fibroblast proliferation and activity without inducing cytotoxicity. It also promotes keratinocyte differentiation, strengthening the epidermal barrier and improving skin hydration. The peptide reduces reactive oxygen species (ROS) accumulation, which contributes to its anti-aging and antioxidative properties.

Applications: Pentapeptide-31 is widely used in cosmetic formulations aimed at reducing fine lines, wrinkles, and sagging skin. It has been investigated in facial serums, eye creams, neck treatments, and hair care products targeting scalp dermal fibroblasts. It works synergistically with other active ingredients such as hyaluronic acid, niacinamide, and vitamin C to enhance overall skin rejuvenation effects.

Safety Profile: As a small peptide, Pentapeptide-31 exhibits minimal irritation potential and high biocompatibility. It has been tested in multiple skin models to ensure tolerability in topical applications.

Experimental Data: Laboratory studies show that Pentapeptide-31 significantly upregulates collagen type I synthesis by over 120% compared to untreated controls, increases elastin deposition by 75%, and reduces matrix metalloproteinase activity, which is implicated in collagen degradation. Its antioxidant capacity helps prevent oxidative damage induced by UVA and UVB exposure.

Conclusion: Pentapeptide-31 is a high-purity peptide ingredient with a robust profile for anti-aging cosmetic research, combining fibroblast stimulation, extracellular matrix support, antioxidant activity, and skin barrier improvement in a single bioactive compound.

Product Specifications

Mechanism of Action

Pentapeptide-31 exerts anti-aging effects through multiple interconnected mechanisms:

1. Fibroblast Activation:
   Pentapeptide-31 binds to fibroblast surface receptors, activating MAPK and SMAD pathways. This enhances transcription of collagen (types I and III) and elastin genes, resulting in increased extracellular matrix deposition.

2. Matrix Metalloproteinase Inhibition:
   The peptide downregulates MMP-1 and MMP-3 expression, which are enzymes responsible for collagen and elastin degradation. By inhibiting these proteases, Pentapeptide-31 reduces structural protein loss in the dermis.

3. Antioxidant Activity:
   Pentapeptide-31 reduces intracellular ROS and prevents oxidative stress-induced damage to fibroblasts and keratinocytes. This helps mitigate photoaging and environmental skin damage.

4. Keratinocyte Differentiation:
   Pentapeptide-31 promotes keratinocyte maturation, enhancing stratum corneum integrity and reducing transepidermal water loss.

5. Synergistic Effects:
   When combined with hyaluronic acid, niacinamide, or other cosmetic actives, Pentapeptide-31 demonstrates additive effects on skin hydration, elasticity, and wrinkle reduction.

6. Hair Follicle Support:
   Studies indicate that Pentapeptide-31 may stimulate dermal papilla fibroblasts, promoting hair follicle growth and scalp skin regeneration.

Overall, the peptide acts as a multi-target signaling molecule, supporting cellular repair, matrix restoration, and antioxidant defenses, resulting in visible anti-aging benefits.

Side Effects

Pentapeptide-31 has demonstrated excellent tolerability:

• Topical Use: Minimal irritation in skin patch tests, even at concentrations up to 5%.

• Cellular Models: No cytotoxicity observed in fibroblast or keratinocyte cultures at relevant cosmetic concentrations.

• Allergenicity: Low potential; does not trigger histamine release in in vitro mast cell assays.

• Long-Term Exposure: No adverse effects on cellular proliferation or differentiation in 12-month stability studies.

• Comparison to Other Peptides: Exhibits superior dermal penetration and activity with lower irritation than traditional hexapeptides and pentapeptides.

Even with chronic use in cosmetic formulations, Pentapeptide-31 has shown an excellent safety profile, supporting its application in anti-aging creams, serums, and scalp treatments.

Keywords

Pentapeptide-31, bioactive peptide, cosmetic peptide, anti-aging peptide, wrinkle reduction, skin rejuvenation, collagen stimulator, elastin promoter, high purity, lyophilized powder

Shipping Guarantee

All shipments are handled using validated cold-chain logistics to preserve peptide integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage.

Trade Assurance

We ensure product authenticity, verified ≥99% purity, and compliance with analytical standards (HPLC, MS, and NMR). Each batch is supplied with a Certificate of Analysis (CoA). Our trade assurance policy guarantees replacement or refund for any deviation from listed specifications.

Payment Support

We provide flexible and secure global payment options to support international research transactions. Accepted payment methods include PayPal, major credit cards (Visa, MasterCard, American Express), telegraphic transfer (T/T), and cryptocurrencies (USDT, Bitcoin, Ethereum). All transactions are protected by industry-standard encryption and verified payment gateways to ensure confidentiality and fund security.

Disclaimer

All products listed are intended for laboratory research use only and not for human or veterinary use. They are not drugs, medical devices, or diagnostics and should not be administered to humans or animals. Researchers must handle all materials in accordance with institutional biosafety and chemical safety guidelines. The information provided is for scientific reference only and does not imply therapeutic efficacy, safety, or regulatory approval.