Description

Pexiganan, also known as MSI-78, is a synthetic 22-amino-acid cationic peptide derived from magainin II, a naturally occurring host-defense peptide. It exhibits strong antibacterial effects against Gram-positive and Gram-negative bacteria by disrupting bacterial cell membranes, leading to rapid cell death.

This antimicrobial peptide has been widely studied for its potential applications in infection models, wound healing, and resistance mechanism research. Due to its stability and low likelihood of resistance development, Pexiganan is considered an important model compound in antimicrobial research.

Our Pexiganan is manufactured in a GMP-compliant facility, ensuring consistency, purity, and traceability for laboratory research purposes. With ?99.31% purity, it is suitable for high-standard microbiology, pharmaceutical, and biochemical investigations.

Product Specifications

Mechanism of Action & Research Applications

Pexiganan works primarily by binding to bacterial cell membranes and forming pores, leading to the leakage of essential ions and metabolites. This disruption results in rapid bacterial death without requiring internal cellular targeting.

In research, Pexiganan is frequently used in:

• Antimicrobial activity studies against resistant bacterial strains

• Wound healing models, including diabetic ulcer infection simulations

• Resistance mechanism analysis in microbiology

• Peptide structure-activity relationship (SAR) studies for drug development

Its low tendency to induce resistance makes it an attractive candidate for exploring alternative antimicrobials.

Side Effects (For Reference Only in Models)

In laboratory models, high concentrations of Pexiganan may cause mild cytotoxicity to mammalian cells. No systemic side effects have been observed in controlled experimental setups, but contact with human or animal tissue outside of research protocols is prohibited.

Disclaimer

Pexiganan provided by our facility is intended only for laboratory research use. It is not approved for human or veterinary administration. All handling should follow appropriate safety protocols.