Description

Pregabalin is widely used in neuroscience and CNS pharmacology labs. It is chemically related to GABA but works by modulating calcium influx in hyperexcited neurons. Its applications span from pain signaling models to seizure threshold studies and behavioral pharmacology.

Product Specifications

Mechanism of Action

Pregabalin binds to the ?2-? subunit of voltage-gated calcium channels in the CNS. It reduces calcium-dependent neurotransmitter release in overactive neurons, which accounts for its analgesic, anticonvulsant, and anxiolytic effects. It does not bind to GABA or benzodiazepine receptors.

Research Applications

• Neuropathic Pain Models
  Used in animal models of diabetic neuropathy, spinal cord injury, and post-herpetic neuralgia to assess analgesic mechanisms.

• Seizure Threshold Studies
  Evaluated in absence, tonic-clonic, and partial seizure models to study anticonvulsant efficacy.

• Anxiety and Behavior
  Assessed in rodents using elevated plus maze, open field test, and GAD-related behavioral assays.

• Neuroinflammation & CNS Injury
  May impact microglial activation and inflammatory cytokines in CNS trauma models.

Safety Profile & Handling

• Observed Lab Effects: Sedation, reduced locomotion, ataxia, or bradycardia in high doses during trials.

• Handling: Use gloves and lab-grade safety gear. Avoid ingestion or inhalation.

• Shelf Life: 36 months in unopened packaging stored under standard conditions.

Core Keywords

Pregabalin, Pregabalin 75mg Capsules, CAS 148553-50-8, neuropathic pain research, anticonvulsant lab use, calcium channel modulator, CNS pharmacology, pregabalin lab-grade, wholesale pregabalin

Research-Use Disclaimer

This product is supplied exclusively for laboratory research use. It is not approved for therapeutic, diagnostic, or veterinary use. Misuse or improper handling may pose health risks. Always follow institutional biosafety and handling protocols.