Description
Propofol Emulsion Product Specifications
| Attribute | Details |
|---|---|
| Product Name | Propofol Emulsion Injection |
| Generic Name | Propofol (2,6?diisopropylphenol) |
| CAS Number | 2078?54?8 (propofol) |
| Molecular Formula | C??H??O |
| Molecular Weight | 178.27?g/mol en.wikipedia.org+9accessdata.fda.gov+9en.wikipedia.org+9 |
| Dosage Form | Sterile oil-in-water emulsion (IV) |
| Strength | 0.2?g / 20?mL vial |
| Pack Size | 5 vials per box |
| Approval Number | China NMPA H20223914 |
| Product Code | 86910137000036 |
| Manufacturer | Jiangsu Yingke Biopharmaceutical Co., Ltd. |
| Storage Conditions | Store at 2–25?°C; protect from light; shake before use |
| Sterility | Sterile, non?pyrogenic |
| Intended Use | Laboratory research only |
Propofol Emulsion Mechanism of Action
Propofol acts as a positive allosteric modulator of GABAA_A receptors, enhancing inhibitory neurotransmission. It also exhibits mild sodium-channel and nicotinic acetylcholine receptor inhibition .
Research Applications & Pharmacology
Neuropharmacology & Anesthesia Models: Ideal for in vivo preclinical anesthesia induction/maintenance and monitored anesthesia care models. Commonly dosed at 2–10?mg/kg in rodents .
Sedation & ICU Research: Used in infusion-based sedation and propofol infusion syndrome models.
In Vitro Studies: Reference agent in GABAergic, neurodegeneration and pharmacokinetic assays.
Pharmacokinetics: Rapid onset (15–40?s), short duration (~5–10?min), high protein binding (95–99%), hepatic metabolism via glucuronidation/oxidation .
Safety Profile & Handling
Adverse Effects: Hypotension, respiratory depression, pain on injection, myoclonus .
Handling: Use aseptic technique; single?use vial; draw and administer promptly; discard within 12?hrs after opening .
Allergens: Contains egg lecithin and soybean oil—avoid cross?reactivity.
Storage: 2–25?°C, protect from light; shake until uniform before use.


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