Description

Product Description

Protein Kinase C β Peptide (CAS 309247-50-5) is a research-grade peptide derived from the β isoform of Protein Kinase C (PKCβ), a member of the serine/threonine kinase family that plays a crucial role in cellular signal transduction. PKCβ is activated by diacylglycerol and calcium ions and is intimately involved in modulating vascular tone, inflammation, and endothelial function.

This peptide fragment represents a functional domain of PKCβ that can be used in studies investigating kinase regulation, phosphorylation events, and downstream signaling mechanisms. Hyperglycemia has been shown to activate PKCβ, leading to endothelial dysfunction through the reduction of nitric oxide bioavailability. The use of PKCβ inhibitors—or its peptide analogs—has demonstrated the ability to restore normal endothelial-dependent vasodilation in experimental models.

Protein Kinase C β Peptide serves as a powerful research tool for exploring the molecular basis of vascular complications in diabetes, including retinopathy, nephropathy, and atherosclerosis. Researchers employ this peptide to dissect the complex interactions between PKCβ signaling and nitric oxide synthase pathways.

Beyond vascular studies, PKCβ is also implicated in immune responses, cell proliferation, and apoptosis. The peptide fragment can be used to map phosphorylation targets or design selective inhibitors for therapeutic exploration.

Applications include:

• Studying PKCβ-mediated endothelial signaling

• Modeling hyperglycemia-induced vascular dysfunction

• Screening for kinase inhibitors in metabolic disease research

• Investigating nitric oxide production and oxidative stress regulation

Protein Kinase C β Peptide is synthesized to high purity and suitable for use in in vitro biochemical assays, protein interaction studies, and cell-based experiments. It enables precise modulation of kinase activity and supports the identification of new therapeutic targets for cardiovascular and metabolic disorders.

5. Product Specifications

Synonyms

• PKCβ Peptide Fragment

• Protein Kinase C Beta Peptide Fragment

• PKC Beta Signal Peptide

• PKCβ Domain Peptide

Mechanism of Action

Protein Kinase C β (PKCβ) is activated under conditions of elevated glucose concentration, which results in increased diacylglycerol (DAG) levels and subsequent activation of PKCβ signaling pathways. Activated PKCβ phosphorylates multiple target proteins in endothelial cells, leading to decreased nitric oxide (NO) bioavailability and impaired vasodilation.

Protein Kinase C β Peptide acts as a molecular tool to study this pathway by mimicking or interfering with endogenous PKCβ interactions. Through modulation of phosphorylation cascades, the peptide enables controlled exploration of the relationship between PKCβ activity and endothelial nitric oxide synthase (eNOS) regulation.

Experimental inhibition of PKCβ or competition via this peptide fragment restores endothelium-dependent vasodilation, highlighting PKCβ’s critical role in vascular homeostasis and hyperglycemia-induced endothelial dysfunction.

Side Effects / Safety Notes

This peptide is intended for research use only and not for human or animal therapeutic applications. Handling should be performed by qualified laboratory professionals. No known adverse biological effects have been reported in research concentrations. Avoid direct contact, inhalation, or ingestion.

Disclaimer

All products are for laboratory research use only. Not for diagnostic, therapeutic, or human consumption. Product data and performance depend on the specific research context.

Keywords

protein kinase c beta peptide, PKCβ peptide fragment, endothelial dysfunction research peptide, nitric oxide modulation peptide, vascular signaling peptide, kinase inhibitor peptide, peptide supplier, custom peptide synthesis, research chemicals manufacturer, peptide for diabetes vascular research.

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