Description

Product Description

Quinupristin Mesylate (CAS 120138-50-3) is a synthetic streptogramin antibiotic renowned for its potent ability to inhibit bacterial protein synthesis. Streptogramins are a unique class of antibiotics that target bacterial ribosomes, and Quinupristin Mesylate specifically binds to the 50S subunit, preventing the elongation of nascent polypeptides and promoting premature release of incomplete proteins. This action disrupts bacterial growth and protein production, making it an invaluable tool for laboratory research.

Produced in a GMP-certified facility, Quinupristin Mesylate ensures high purity, batch-to-batch reproducibility, and quality suitable for both wholesale and retail applications. The lyophilized powder format maintains stability during storage and shipping, allowing researchers to reliably conduct experiments without concerns of degradation.

Quinupristin Mesylate is widely utilized in studies exploring mechanisms of antimicrobial resistance, allowing scientists to investigate bacterial adaptation, resistance gene expression, and ribosomal mutation impacts. It is also employed in synergistic antibiotic studies, where it is combined with other antimicrobial agents to assess potential additive or antagonistic effects.

Furthermore, this compound is valuable for pharmacokinetics and pharmacodynamics research, enabling preclinical studies on bacterial metabolism, protein synthesis inhibition kinetics, and dose-response relationships. Its application extends to molecular biology experiments focused on ribosomal interactions and bacterial protein regulation.

Disclaimer: For laboratory research use only, not for human or veterinary use.

Product Specifications

Mechanism of Action & Research Applications

Mechanism of Action

Quinupristin Mesylate binds specifically to the 50S ribosomal subunit, disrupting bacterial protein synthesis. Its mechanisms include:

• Peptide bond inhibition: Prevents elongation of nascent proteins.

• Premature chain release: Leads to truncated, nonfunctional proteins.

• Bacteriostatic or bactericidal effects: Dependent on concentration and bacterial species.

This precise action allows researchers to examine bacterial growth inhibition, ribosomal target engagement, and the biochemical consequences of protein synthesis blockade.

Research Applications

1. Bacterial Protein Synthesis Studies: Examine the impact of ribosomal inhibition on bacterial physiology.

2. Antimicrobial Resistance Mechanisms: Investigate resistance gene expression and ribosomal mutations.

3. Synergistic Antibiotic Studies: Explore combinatory effects with other antimicrobial compounds.

4. Pharmacodynamics and Pharmacokinetics: Study absorption, distribution, metabolism, and bacterial protein synthesis kinetics.

5. Molecular Biology Research: Understand ribosomal interactions and bacterial proteome modulation.

6. Preclinical Laboratory Research: Model antibiotic response, resistance development, and protein synthesis inhibition.

7. High-throughput Screening: Assess compound libraries for ribosomal binding or inhibitory effects.

   

Side Effects (For Reference in Research Models)

In experimental settings, Quinupristin Mesylate may produce:

• Altered bacterial growth patterns, dependent on dose and strain.

• Changes in bacterial protein expression profiles.

• Emergence of resistance genes under prolonged exposure.

• Dose-dependent effects on ribosomal function.

Note: Observed effects are strictly for laboratory research reference and do not constitute clinical safety data.

Disclaimer

Quinupristin Mesylate is supplied exclusively for laboratory research purposes. For laboratory research use only, not for human or veterinary use. It is not a dietary supplement or therapeutic agent. All handling must follow proper laboratory safety protocols.

Keywords

• Quinupristin Mesylate

• Quinupristin Mesylate CAS 120138-50-3

• Streptogramin antibiotic

• GMP Manufacturer antibiotic

• Bacterial protein synthesis inhibitor

• Laboratory research antibiotic

• Antimicrobial resistance studies

• Protein synthesis inhibition studies

• Wholesale Quinupristin Mesylate

• Retail Quinupristin Mesylate