描述
Human Follitropin Product Specifications
Specification | Details |
---|---|
Product Name | Recombinant Human Follitropin Injection (Jinsaiheng®) |
Generic Name | Follitropin alfa (r?hFSH) |
Synonyms | Recombinant human FSH, FSH alfa, r?hFSH |
CAS Number | — (Recombinant glycoprotein from CHO) |
Strength | 5.5?µg (75?IU) per vial |
Pack Size | 10 vials per box |
Dosage Form | Injectable solution (small-volume vial) |
Approval Number | NMPA China: S20150007 |
Product Code | 86903315000263 |
Manufacturer | Changchun Jinsai Pharmaceutical Co., Ltd. |
Storage | 2–8?°C refrigeration, protect from light |
Dosage Form | Injectable solution (for laboratory research only) |
Human Follitropin Mechanism of Action
r?hFSH (follitropin alfa) binds to follicle-stimulating hormone receptors (FSHR) on granulosa cells, activating intracellular PI3K/Akt pathways to stimulate follicular growth and maturation—mirroring endogenous FSH activity in fertility research arxiv.org+15go.drugbank.com+15mdpi.com+15bio-techne.comaccessdata.fda.gov.
Human Follitropin Research Applications & Pharmacology
-
Ovarian Stimulation & ART Protocols: Widely used in controlled ovarian hyperstimulation; Jinsaiheng® shows comparable performance to GONAL?F, with cumulative live birth rates around 84.4% vs. 88.3% for GONAL?F .
-
Preclinical Infertility Models: Used in rodent and primate studies (75–300?IU/day) to induce follicle development .
-
Biosimilar Comparisons: As a biosimilar, Jinsaiheng exhibits near-identical bioactivity to reference follitropin alfa, efficient follicle recruitment, and has cost advantages over originator .
?? Research?Use Disclaimer
This product is intended exclusively for laboratory and preclinical research. It is not approved for clinical, therapeutic, diagnostic, or veterinary use and may pose health and regulatory risks if misused.
评价
目前还没有评价