描述
Recombinant Human G?CSF Product Specifications
Attribute | Details |
---|---|
Product Name | Recombinant Human G?CSF Injection (Lishengsu®) |
Active Ingredient | Filgrastim (recombinant human G?CSF) |
Strength | 150?µg per vial |
Quantity | 5 vials per box |
Dosage Form | Injectable solution (non-sterile, for research use) |
Approval No. | China NMPA S19980010 |
Product Code | 86900148000828 |
Barcode | 6944580400383 |
Manufacturer | Beijing SL Pharmaceutical Co., Ltd. |
Intended Use | Laboratory research only — not for clinical or veterinary use |
Mechanism of Action
Filgrastim is a recombinant form of human G?CSF that binds the G?CSF receptor on hematopoietic progenitors, activating JAK/STAT and MAPK pathways. It stimulates proliferation, differentiation, and release of neutrophils from bone marrow.
Research & Pharmacology Context
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G?CSF is widely used in experimental models to reverse chemotherapy-induced neutropenia and to aid bone marrow transplant recovery.
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Short-acting form (filgrastim) clears in about 3.5?h post subcutaneous injection; primarily excreted via kidneys in animal studies.
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G?CSF also displays neuroprotective effects in preclinical stroke and spinal cord injury models (activates AKT/ERK signaling).
pmc.ncbi.nlm.nih.gov+2pmc.ncbi.nlm.nih.gov+2link.springer.com+2 -
Meta-analyses in Chinese patients show long-acting G?CSF offers similar efficacy and reduced severe neutropenia compared to short-acting forms.
journals.lww.com
Research Applications
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Preclinical chemotherapy-induced neutropenia models
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Bone marrow transplant engraftment studies
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JAK/STAT and MAPK pathway activation research
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Neuroprotection in stroke/spinal cord injury models
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Comparative pharmacokinetics of short- vs long-acting G?CSF preparations
?? Research?Use Only Disclaimer
This product is provided strictly for laboratory research and development use only. Not for clinical, diagnostic, therapeutic, or veterinary applications.
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