Description

Product Description

Rigin, also known as Tetrapeptide-3 or GQPR, is a synthetic peptide composed of glycine, glutamine, proline, and arginine. It has gained significant attention in cosmetic and dermatological research for its proven anti-wrinkle and skin-repairing effects. Functionally, Rigin acts as a bioactive messenger peptide that enhances dermal resilience, reduces inflammation, and improves tissue cohesion by modulating extracellular matrix (ECM) dynamics.

As skin ages, fibroblast activity decreases, collagen synthesis declines, and the dermal structure weakens. These changes contribute to fine lines, sagging, and a dull complexion. Rigin counteracts these effects by activating key biological pathways associated with skin homeostasis and tissue repair. Its tetrapeptide sequence (GQPR) mimics a fragment of immunoglobulin G (IgG), a structure known to influence cellular communication and anti-inflammatory responses.

In vitro studies have shown that Rigin stimulates fibroblast proliferation and upregulates the synthesis of collagen and fibronectin, the primary proteins responsible for maintaining dermal elasticity and strength. Moreover, Rigin helps normalize cytokine activity, particularly interleukin-6 (IL-6), thereby mitigating chronic inflammation often associated with skin aging.

This peptide’s multifunctional action makes it a valuable compound in cosmetic peptide research, especially for formulations targeting mature, fatigued, or inflamed skin. When used in experimental formulations, Rigin demonstrates visible improvements in skin firmness, smoothness, and tone due to its ability to strengthen dermal structure and restore the balance of pro- and anti-inflammatory mediators.

Its anti-aging benefits extend to barrier repair and tissue resilience enhancement. By stabilizing ECM interactions and promoting optimal cell adhesion, Rigin helps maintain skin integrity under oxidative or environmental stress. Researchers studying the molecular mechanisms of Rigin often focus on its role in the modulation of gene expression linked to dermal reconstruction, collagen fiber alignment, and cytokine balance — all critical for anti-aging research.

Rigin has also been reported to synergize effectively with other cosmetic peptides such as Palmitoyl Tetrapeptide-7 (Matrixyl 3000) and Palmitoyl Oligopeptide, which together can amplify collagen synthesis and skin-smoothing effects. Due to its safety profile, biocompatibility, and stability, Rigin is widely used in experimental anti-aging formulations for laboratory testing and product development.

Product Specifications

Mechanism of Action

The mechanism of Rigin’s bioactivity is multifaceted and centers on regulating fibroblast metabolism, collagen synthesis, and inflammatory signaling.

1. Regulation of Cytokine Activity:
   Rigin downregulates pro-inflammatory cytokines such as IL-6, helping reduce chronic dermal inflammation that accelerates skin aging.

2. Collagen and Fibronectin Enhancement:
   The peptide upregulates the expression of ECM proteins, including type I collagen and fibronectin, restoring firmness and elasticity.

3. Normalization of Cellular Communication:
   Rigin’s GQPR sequence interacts with specific receptors that improve cell signaling, ensuring optimal fibroblast-keratinocyte communication for tissue renewal.

4. Barrier Function Strengthening:
   By stabilizing ECM structures, Rigin enhances the skin’s protective barrier, improving resistance to environmental stressors.

5. Antioxidant and Detoxifying Support:
   Rigin reduces oxidative stress within dermal cells, preserving the structural proteins from glycation and oxidation.

6. Synergy with Other Peptides:
   Rigin is often studied in conjunction with Palmitoyl Tetrapeptide-7, forming the Matrixyl 3000 complex, which amplifies anti-wrinkle and firming effects.

Together, these mechanisms define Rigin as a powerful research ingredient in studies focusing on rejuvenation, skin elasticity, and wrinkle prevention.

Side Effects

Rigin exhibits excellent safety and tolerance profiles in experimental and cosmetic research settings. It is a non-irritating, non-sensitizing peptide with no evidence of cytotoxicity or mutagenicity.

Potential considerations include:

• Mild Sensitivity: At very high concentrations, minor irritation may occur in sensitive skin models.

• Oxidation Sensitivity: Like all peptides, exposure to heat or light can cause degradation, reducing potency.

• Allergic Reactions: Extremely rare; advisable to conduct patch testing in test formulations.

With appropriate storage and handling, Rigin remains stable and effective for long-term laboratory research.

Keywords

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Shipping Guarantee

All shipments are handled using validated cold-chain logistics to preserve peptide integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage.

Trade Assurance

We ensure product authenticity, verified ≥99% purity, and compliance with analytical standards (HPLC, MS, and NMR). Each batch is supplied with a Certificate of Analysis (CoA). Our trade assurance policy guarantees replacement or refund for any deviation from listed specifications.

Payment Support

We provide flexible and secure global payment options to support international research transactions. Accepted payment methods include PayPal, major credit cards (Visa, MasterCard, American Express), telegraphic transfer (T/T), and cryptocurrencies (USDT, Bitcoin, Ethereum). All transactions are protected by industry-standard encryption and verified payment gateways to ensure confidentiality and fund security.

Disclaimer

All products listed are intended for laboratory research use only and not for human or veterinary use. They are not drugs, medical devices, or diagnostics and should not be administered to humans or animals. Researchers must handle all materials in accordance with institutional biosafety and chemical safety guidelines. The information provided is for scientific reference only and does not imply therapeutic efficacy, safety, or regulatory approval.