描述
Roxadustat is a selective oral hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitor that promotes erythropoiesis by stabilizing HIF proteins, enhancing endogenous erythropoietin production and improving red blood cell formation. It is widely studied for potential treatment of anemia related to chronic kidney disease and hypoxic conditions.
This formulation delivers 50mg roxadustat per capsule, supplied as 3 capsules per blister pack, suitable for in vitro and in vivo research including anemia models, oxygen sensing mechanisms, and metabolic regulation.
Manufactured by Hunan Mingrui Pharmaceutical Co., Ltd., under NMPA approval number H20249733 and product code 86905001000243.
?? For laboratory research use only. Not for human or veterinary use.
Product Specifications
Parameter | Details |
---|---|
Product Name | Roxadustat Capsules (Dingle) |
Generic Name | Roxadustat |
CAS Number | 808118-40-3 |
Molecular Formula | C21H23N3O5 |
Molecular Weight | 351.43 g/mol |
Dosage Form | Capsule |
Strength | 50mg per capsule |
Quantity | 3 capsules per blister pack |
Approval Number | H20249733 (China NMPA) |
Product Code | 86905001000243 |
Manufacturer | Hunan Mingrui Pharmaceutical Co., Ltd. |
Barcode | 6920945601329 |
Intended Use | Laboratory research only |
Storage Conditions | Store sealed below 25°C, protected from moisture and light |
Mechanism & Research Applications
Roxadustat works by inhibiting HIF prolyl hydroxylase enzymes, which leads to the stabilization of hypoxia-inducible factors (HIFs). These transcription factors then increase the production of endogenous erythropoietin, stimulating red blood cell production. This mechanism is valuable for research into anemia of chronic kidney disease, hypoxia-related diseases, and oxygen homeostasis.
Research applications include cellular assays, animal models for anemia and hypoxia, gene expression studies targeting HIF pathways, and metabolic regulation research.
Safety & Handling
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Use Restriction: For laboratory research only; not for clinical, diagnostic, or veterinary use.
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Protective Equipment: Gloves, lab coat, and eye protection recommended.
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Storage: Keep sealed and stored below 25°C, away from moisture and light.
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Disposal: Dispose of according to institutional and environmental regulations.
Research Use Disclaimer
This product is intended solely for laboratory research. It is not approved for therapeutic, diagnostic, or veterinary purposes. Improper use may cause health or legal risks. Please comply with all relevant safety and handling protocols.
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