Description

Product Description

SA1-III, chemically identified as KP1 and assigned CAS number 2673230-58-3, is a synthetic bioactive peptide that has become a prominent focus of modern cosmetic peptide research. Known for its capacity to promote collagen regeneration, dermal restructuring, and anti-aging effects, SA1-III represents a breakthrough in peptide-based skin rejuvenation technologies.

At its molecular level, SA1-III functions as a signal peptide, transmitting biological messages to dermal fibroblasts to stimulate collagen production and improve extracellular matrix organization. Through this biomimetic mechanism, it helps restore structural integrity to aged or photo-damaged skin, offering a highly valuable research model for the study of wrinkle reduction and tissue regeneration.

Researchers have found that SA1-III increases type I and III collagen synthesis, which are critical components of skin firmness and elasticity. In cell-based assays, it enhances fibroblast activity, promotes cell proliferation, and reduces the expression of matrix metalloproteinases (MMPs)—enzymes that degrade collagen and accelerate visible aging. By modulating these cellular processes, SA1-III contributes to skin smoothness, resilience, and hydration retention.

The peptide’s activity extends to protecting cells against oxidative stress and environmental insults such as UV radiation. Its antioxidant capabilities help neutralize free radicals, thereby supporting long-term dermal preservation. In addition, SA1-III influences cell–matrix interactions by regulating integrin expression, improving dermal adhesion, and enhancing the mechanical stability of connective tissue structures.

In cosmetic research contexts, SA1-III has been used to model the restoration of collagen networks, tissue elasticity, and skin texture uniformity. Its anti-aging profile makes it a leading candidate in peptide research related to wrinkle smoothing, firmness improvement, and visible rejuvenation without invasive procedures.

Product Specifications

Mechanism of Action

The biological mechanism of SA1-III centers on its ability to mimic natural skin growth factors that regulate collagen synthesis and extracellular matrix dynamics. Acting as a signal peptide, SA1-III binds to fibroblast receptors and activates intracellular signaling cascades, particularly the TGF-β/SMAD pathway. This pathway is well known for its role in regulating collagen gene expression and tissue remodeling.

Once internalized, SA1-III promotes fibroblast proliferation and increases the expression of structural proteins such as collagen types I and III, fibronectin, and elastin. These proteins are essential for maintaining the skin’s mechanical strength and elasticity. The peptide also downregulates the expression of matrix metalloproteinases (MMP-1 and MMP-9), which are responsible for collagen degradation during aging and UV exposure.

By maintaining a favorable balance between synthesis and degradation, SA1-III helps preserve the integrity of the extracellular matrix. It also enhances the synthesis of glycosaminoglycans (GAGs), which are hydrating molecules crucial for maintaining dermal volume and moisture content.

Studies suggest that SA1-III’s activity extends beyond fibroblasts to keratinocytes, where it supports epidermal repair and improves barrier recovery after irritation. In oxidative stress models, SA1-III reduces reactive oxygen species accumulation and enhances antioxidant enzyme activity, further protecting skin cells from aging-related damage.

This dual action—stimulating regeneration while preventing degradation—makes SA1-III an ideal peptide for scientific investigation into non-invasive anti-aging strategies. Researchers studying dermal rejuvenation mechanisms often use SA1-III as a benchmark model for bioactive collagen-promoting peptides.

Side Effects

In laboratory settings, SA1-III demonstrates excellent biocompatibility and stability, showing no significant cytotoxic effects within standard concentration ranges. It is considered safe for in vitro and ex vivo research applications. However, as with all synthetic peptides, researchers are advised to handle SA1-III with sterile techniques and avoid multiple freeze–thaw cycles that can degrade peptide structure.

Although no adverse biological reactions have been reported in research models, this compound is not intended for human or veterinary application. It must only be used in laboratory studies focusing on cosmetic peptide function, molecular anti-aging mechanisms, and collagen restoration research.

Keywords

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Shipping Guarantee

All shipments are handled using validated cold-chain logistics to preserve peptide integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage.

Trade Assurance

We ensure product authenticity, verified ≥99% purity, and compliance with analytical standards (HPLC, MS, and NMR). Each batch is supplied with a Certificate of Analysis (CoA). Our trade assurance policy guarantees replacement or refund for any deviation from listed specifications.

Payment Support

We provide flexible and secure global payment options to support international research transactions. Accepted payment methods include PayPal, major credit cards (Visa, MasterCard, American Express), telegraphic transfer (T/T), and cryptocurrencies (USDT, Bitcoin, Ethereum). All transactions are protected by industry-standard encryption and verified payment gateways to ensure confidentiality and fund security.

Disclaimer

All products listed are intended for laboratory research use only and not for human or veterinary use. They are not drugs, medical devices, or diagnostics and should not be administered to humans or animals. Researchers must handle all materials in accordance with institutional biosafety and chemical safety guidelines. The information provided is for scientific reference only and does not imply therapeutic efficacy, safety, or regulatory approval.