Description
Product Description
Setmelanotide is a synthetic cyclic peptide designed for scientific research focused on melanocortin receptor pathways, particularly the melanocortin-4 receptor (MC4R). This signaling axis plays a critical role in appetite regulation, energy expenditure, and metabolic homeostasis, making the compound highly relevant for endocrine and metabolic research models.
In laboratory settings, Setmelanotide is commonly utilized to study receptor activation mechanisms, downstream signaling cascades, and ligand–receptor specificity within the central melanocortin system. Its defined structure enables controlled investigation of receptor selectivity and functional outcomes across cellular and animal-based experimental platforms.
Due to its stability and predictable biochemical behavior, Setmelanotide supports reproducible experimentation in both in vitro assays and in vivo research models. Researchers employ this peptide to explore hypothalamic signaling, neuroendocrine regulation, and genetic pathways associated with metabolic control.
Supplied as a high-purity raw material, Setmelanotide allows flexible experimental design, including dose–response analysis, mechanistic pathway mapping, and comparative studies with other melanocortin ligands. Each batch is produced under controlled conditions and verified through comprehensive analytical testing to ensure consistency suitable for advanced research use.

Product Specifications
| Item | Description |
|---|---|
| Product Name | Setmelanotide |
| Synonyms | RM-493 |
| CAS Number | 920014-33-1 |
| Molecular Formula | C49H68N18O9 |
| Molecular Weight | ~1113.3 g/mol |
| Amino Acid Sequence | Synthetic cyclic peptide |
| Peptide Type | Cyclic peptide |
| Form | Lyophilized powder |
| Purity | ≥99% (HPLC) |
| Strength Options | Customizable (mg scale) |
| Appearance | White to off-white powder |
| Identity Verification | HPLC, MS |
| Solubility | Soluble in water or suitable buffers |
| Packaging | Sterile glass vial |
| Storage Condition | −20 °C, protected from light |
| Intended Use | Research use only |
Applications
Setmelanotide is widely applied in experimental research related to neuroendocrine regulation and metabolic signaling.
Representative research applications include:
Melanocortin receptor signaling studies
MC4R activation and pathway analysis
Appetite and energy balance research
Neuroendocrine regulation models
Metabolic disorder mechanism studies
Ligand–receptor interaction assays
Comparative studies of melanocortin agonists
In vivo and in vitro endocrine research models
These applications support its role as a reference peptide in melanocortin system research.

Packaging
The product is supplied in sterile, sealed glass vials containing lyophilized peptide material. Bulk quantities, customized specifications, and OEM-style packaging are available to support institutional and laboratory research requirements.

Storage & Transportation
Store at −20 °C in a dry, light-protected environment. Cold-chain transportation is recommended to maintain peptide integrity. Reconstituted solutions should be prepared using sterile laboratory techniques.
Inquiry & Technical Consultation
For Certificates of Analysis, batch documentation, or technical consultation related to Setmelanotide, please contact us through the inquiry form. Support is provided for qualified research users.
Disclaimer
This product is intended for research use only.
Not for human or veterinary use.
All experimental applications must comply with applicable laboratory and regulatory requirements.





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