Sildenafil Citrate Tablets (ChiWei®) 100?mg ×?3 Tablets

Sildenafil Citrate Tablets (ChiWei®) 100?mg ×?3 Tablets

$2.00

Sildenafil citrate is a selective Phosphodiesterase-5 (PDE5) inhibitor widely used in research for erectile dysfunction, pulmonary arterial hypertension, and emerging indications like cardioprotection. This product is supplied as 100?mg tablets in a pack of 3. Strictly for laboratory and preclinical research only, not approved for clinical, diagnostic, therapeutic, or veterinary use.

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Description

Sildenafil Citrate Product Specifications

AttributeDetails
Product NameSildenafil Citrate Tablets (ChiWei®)
Generic NameSildenafil Citrate
CAS Number171599?83?0
Molecular FormulaC??H??N?O?S·C?H?O?
Molecular Weight~666.7?g/mol
Dosage FormOral film-coated tablets
Strength100?mg per tablet
Pack Size3 tablets per blister pack
Approval No.China NMPA H20203599
Product Code86904083000868
ManufacturerGuangzhou Langsheng Pharmaceutical Co., Ltd.
Barcode6944788133717
StorageStore at 15–25?°C; protect from light and moisture
Intended UseLaboratory and preclinical research use only

Sildenafil Citrate Mechanism of Action

Sildenafil is a potent, highly selective PDE5 inhibitor. By preventing cGMP breakdown, it enhances NO-mediated smooth muscle relaxation—increasing blood flow in the corpus cavernosum and pulmonary arteries wired.com+13synapse.patsnap.com+13en.wikipedia.org+13.


Research Applications & Pharmacology

  • Erectile Dysfunction (ED) Models: Used to study the PDE5 pathway, smooth muscle dynamics, and vascular responses .

  • Pulmonary Hypertension: Investigates vasodilatory effects in pulmonary vasculature; improves exercise performance in models .

  • Cardioprotection: Shows myocardial ischemic preconditioning via NO, PKC/ERK signaling, and mitochondrial KATP channels en.wikipedia.org+5pubmed.ncbi.nlm.nih.gov+5nature.com+5.

  • Emerging Research: Evaluated for roles in neurologic (#Alzheimer’s) and placental circulation .

  • Pharmacokinetics: Oral bioavailability ~41%, protein binding ~96%, peak action ~30–60?min, half?life 3–4?h, metabolized via CYP3A4/CYP2C9; excreted mainly fecally (~80%) and renally (~13%) .


Safety Profile & Handling

  • Adverse Effects: Include headache (>10%), flushing, nasal congestion, dyspepsia, and dizziness .

  • Contraindications: Avoid co-administration with nitrates or alpha-blockers in vivo to prevent severe hypotension .

  • Handling Guidelines: Use PPE; store per guidelines; discard expired tablets as per lab protocols.

  • Special Precautions: Avoid in ocular disease models and use caution with cardiovascular-compromised animals

Additional information

Weight1.1 kg
Dimensions18 × 16 × 18 cm

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