Description
Sildenafil Citrate Product Specifications
| Attribute | Details |
|---|---|
| Product Name | Sildenafil Citrate Tablets (ChiWei®) |
| Generic Name | Sildenafil Citrate |
| CAS Number | 171599?83?0 |
| Molecular Formula | C??H??N?O?S·C?H?O? |
| Molecular Weight | ~666.7?g/mol |
| Dosage Form | Oral film-coated tablets |
| Strength | 100?mg per tablet |
| Pack Size | 3 tablets per blister pack |
| Approval No. | China NMPA H20203599 |
| Product Code | 86904083000868 |
| Manufacturer | Guangzhou Langsheng Pharmaceutical Co., Ltd. |
| Barcode | 6944788133717 |
| Storage | Store at 15–25?°C; protect from light and moisture |
| Intended Use | Laboratory and preclinical research use only |
Sildenafil Citrate Mechanism of Action
Sildenafil is a potent, highly selective PDE5 inhibitor. By preventing cGMP breakdown, it enhances NO-mediated smooth muscle relaxation—increasing blood flow in the corpus cavernosum and pulmonary arteries wired.com+13synapse.patsnap.com+13en.wikipedia.org+13.
Research Applications & Pharmacology
Erectile Dysfunction (ED) Models: Used to study the PDE5 pathway, smooth muscle dynamics, and vascular responses .
Pulmonary Hypertension: Investigates vasodilatory effects in pulmonary vasculature; improves exercise performance in models .
Cardioprotection: Shows myocardial ischemic preconditioning via NO, PKC/ERK signaling, and mitochondrial KATP channels en.wikipedia.org+5pubmed.ncbi.nlm.nih.gov+5nature.com+5.
Emerging Research: Evaluated for roles in neurologic (#Alzheimer’s) and placental circulation .
Pharmacokinetics: Oral bioavailability ~41%, protein binding ~96%, peak action ~30–60?min, half?life 3–4?h, metabolized via CYP3A4/CYP2C9; excreted mainly fecally (~80%) and renally (~13%) .
Safety Profile & Handling
Adverse Effects: Include headache (>10%), flushing, nasal congestion, dyspepsia, and dizziness .
Contraindications: Avoid co-administration with nitrates or alpha-blockers in vivo to prevent severe hypotension .
Handling Guidelines: Use PPE; store per guidelines; discard expired tablets as per lab protocols.
Special Precautions: Avoid in ocular disease models and use caution with cardiovascular-compromised animals


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