Silodosin Capsules 4?mg ×?28 Capsules
$2.00
Silodosin is a highly selective ??A?adrenergic receptor antagonist designed to relax smooth muscle in the prostate and bladder neck. These 4?mg capsules, supplied in a 2?×?14?capsule pack by Hainan Wanwei Pharmaceutical, are intended exclusively for laboratory and preclinical research use, such as urological, cardiovascular, and receptor pharmacology studies. Not approved for clinical, diagnostic, therapeutic, or veterinary applications.
描述
Product Specifications
| Attribute | Details |
|---|---|
| Product Name | Silodosin Capsules |
| Generic Name | Silodosin |
| CAS Number | 160970?54?7 |
| Molecular Formula | C??H??F?N?O? |
| Molecular Weight | ~495.5?g/mol |
| Dosage Form | Oral gelatin capsule |
| Strength | 4?mg per capsule |
| Pack Size | 4?mg ×?14 capsules ×?2 blisters per box |
| Approval Number | China NMPA H20213639 |
| Product Code | 86982249000037 |
| Manufacturer | Hainan Wanwei Pharmaceutical Co., Ltd. |
| Barcode | — (not provided) |
| Storage Conditions | Store at 15?25?°C; protect from light |
| Intended Use | Laboratory and preclinical research only |
Mechanism of Action
Silodosin is a highly selective ??A?adrenergic receptor antagonist that relaxes prostate, bladder neck, and urethral smooth muscle, enhancing urinary flow. It has a >500?fold selectivity for ??A over ??B receptors, minimizing systemic hypotension sciencedirect.com+15selleckchem.com+15pubmed.ncbi.nlm.nih.gov+15.
Research Applications & Pharmacology
Benign Prostatic Hyperplasia (BPH):
-
Employed in preclinical models to study symptomatic relief via smooth muscle relaxation .
Urological & Cardiovascular Research:
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Enables exploration of urinary symptomatology with minimal cardiovascular side effects, a desirable profile in cardiovascular-sensitive studies pubmed.ncbi.nlm.nih.gov.
Receptor Pharmacology:
-
Used in vitro and ex vivo assays to evaluate ??A antagonism. Notably, it shows high affinity (Ki ~0.036?nM) and effectively inhibits receptor-mediated contractions across species .
Pharmacokinetics:
-
Orally bioavailable (~32%), protein binding ~96.6%, metabolized via UGT2B7 and CYP3A4, half-life ~13?±?8?h, excreted ~34% unabsorbed renally and ~55% fecally .
Safety Profile & Handling
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Cardiovascular Effects: Selectivity for ??A minimizes blood pressure changes; no QT prolongation observed .
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Common Adverse Events: Dizziness, orthostatic hypotension, dry eyes/mouth, diarrhea, headaches, and retrograde ejaculation.
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Hepatic & Renal Cautions: Dose adjustments recommended in moderate renal impairment; contraindicated in severe renal/liver dysfunction.
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Drug Interactions: Contraindicated with strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, ritonavir) .
-
Handling: Use standard lab PPE, store in a controlled environment, and dispose of per biosafety guidelines.
其他信息
| 重量 | 1 公斤 |
|---|---|
| 尺寸 | 18 × 16 × 18 厘米 |
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