Description

Sincalide Ammonium (cholecystokinin octapeptide ammonium, CAS 70706-98-8) is a synthetic analog of cholecystokinin that retains the physiological activities of the natural hormone. It promotes gallbladder contraction, bile secretion, and sphincter of Oddi relaxation, facilitating bile drainage. It also stimulates pancreatic enzyme secretion, accelerates small intestine transit, and shows protective cardiovascular effects such as reducing myocardial fibrosis via the CCK? receptor and PI3K/Akt pathway. Produced with a purity of 99.90% in GMP-compliant facilities, Sincalide Ammonium provides reliable quality for advanced gastrointestinal, hepatobiliary, and cardiovascular research.

Product Specifications

Mechanism of Action & Research Applications

Sincalide Ammonium is a cholecystokinin analog that stimulates gallbladder contraction, bile secretion, and sphincter of Oddi relaxation—facilitating digestion processes. It also enhances pancreatic enzyme release, shortens intestinal transit time, and can reduce myocardial fibrosis in experimental models via CCK? receptor activation and PI3K/Akt signaling. It is widely used for studies involving hepatobiliary function, gastrointestinal motility, pancreatic secretion, and cardiovascular peptide signaling mechanisms.

Side Effects (For Reference Only)

Designed for laboratory use, Sincalide Ammonium may cause adverse effects in experimental models such as nausea, abdominal discomfort, or hypotension with rapid infusion. Any clinical-use data is not applicable—handle with standard lab safety protocols.

Disclaimer

This product is strictly intended for laboratory research use only. It is not approved for human or veterinary use. Please adhere to institutional safety guidelines when handling.