Description

Sincalide, also known as Cholecystokinin octapeptide (CCK-8), is a synthetic peptide analogue of the natural gastrointestinal hormone cholecystokinin. It mimics the biological effects of endogenous CCK by binding to the same receptors, primarily CCK-A receptors.

Sincalide stimulates gallbladder contraction, pancreatic enzyme secretion, and bile flow, making it valuable in gastrointestinal motility and digestive function studies. It promotes bile drainage into the duodenum by increasing bile secretion, contracting the gallbladder, and relaxing the sphincter of Oddi. This compound is often used in postevacuation cholecystography research and in studies of pancreatic and biliary physiology.

Sincalide is manufactured in a GMP-compliant facility to ensure high quality, consistency, and 99.01% purity.

For laboratory research use only. Not for human or veterinary use.

Product Specifications

Mechanism of Action & Research Applications

Sincalide mimics the action of cholecystokinin (CCK) by binding to CCK receptors, primarily the CCK-A subtype found in the gallbladder and pancreas. Through receptor-mediated activity, Sincalide promotes the release of digestive enzymes from the pancreas, triggers gallbladder contraction, and relaxes the sphincter of Oddi, facilitating bile flow into the duodenum.

Research Applications:

• Gallbladder contractility studies

• Postevacuation cholecystography

• Bile secretion and digestive hormone studies

• Pancreatic enzyme secretion research

• Gastrointestinal motility studies

• Hormonal receptor binding research

  

Precautions

In laboratory environments, Sincalide may:

• Induce transient gastrointestinal cramping in animal models

• Alter bile acid composition and flow rate

• Modulate pancreatic enzyme secretion

These observations are limited to preclinical models and are not applicable to humans or clinical settings.

Inquiry & Technical Consultation

For technical questions, batch-specific analytical data, COA documentation, or formulation guidance related to Sincalide peptide, please submit your inquiry via the contact form below.
Our technical team is available to provide documentation and research support.

Disclaimer

This product is manufactured in a GMP-compliant factory and intended strictly for laboratory research use only. It is not approved for clinical use, diagnosis, therapeutic applications, or veterinary procedures.