Sitagliptin and Metformin Hydrochloride Extended-Release Tablets – For Laboratory Use Only

描述

Sitagliptin and Metformin Hydrochloride Extended-Release Tablets are a fixed-dose combination widely used in experimental studies involving type 2 diabetes mellitus (T2DM). This dual-action formulation features a DPP-4 inhibitor (sitagliptin) and a biguanide (metformin)—making it highly relevant for glucose metabolism, insulin resistance, and incretin pathway research.

Developed by Qilu Pharmaceutical (Hainan) Co., Ltd., this compound is approved under H20253718 and is intended exclusively for in vitro or in vivo laboratory research.

?? Not for human or animal consumption. For experimental use only.

Product Parameters

Mechanism & Research Applications

This combination tablet works via two complementary mechanisms:

• Sitagliptin inhibits DPP-4, increasing incretin hormones (GLP-1, GIP), enhancing insulin release and reducing glucagon in hyperglycemia.

• Metformin reduces hepatic glucose production and improves peripheral glucose uptake.

Research applications include:

• Glucose metabolism and insulin resistance studies

• Evaluation of incretin pathway regulation

• Investigations in combination therapy vs monotherapy efficacy

• Experimental models of T2DM progression and treatment resistance

• Preclinical pharmacokinetic and bioavailability analysis

Observed Effects in Research

Studies using this combination have reported:

• Enhanced insulin sensitivity

• Reduced postprandial glucose spikes

• Improved ?-cell preservation

• Attenuated hepatic gluconeogenesis

• Synergistic glycemic control vs monotherapies

Safety & Handling

• Use: For in vitro and in vivo research only

• Protective Measures: Wear gloves, lab coat, and eye protection

• Storage: Keep sealed, dry, and below 25°C

• Disposal: As per lab chemical protocols

Research Use Disclaimer

This product is intended strictly for laboratory research use only. It is not for human use, diagnosis, or treatment. Proper lab safety and handling procedures must be followed. Misuse is prohibited and may be subject to local regulations.