Description

Product Description

SNF-8814 (CAS 137442-16-1) is a synthetic cholecystokinin (CCK) analog that reproduces several physiological effects of native CCK peptides in the gastrointestinal tract. CCK is a key peptide hormone involved in the regulation of pancreatic enzyme secretion, gallbladder contraction, satiety, and gastric emptying. SNF-8814 was developed as a research analog to investigate CCK receptor function and the downstream physiological responses in digestive system models.

This analog binds to CCK receptors (CCK-A and CCK-B), initiating intracellular signaling cascades that regulate calcium mobilization, enzyme secretion, and smooth muscle contraction. Because of its selectivity and controlled potency, SNF-8814 has become a valuable experimental tool for understanding receptor pharmacology, gastrointestinal hormone interplay, and peptide-based drug development.

Research Significance

CCK analogs like SNF-8814 are critical in gastrointestinal and neuroendocrine research. They allow scientists to:

• Study the effects of CCK receptor activation on pancreatic secretion.

• Explore the mechanisms of digestive motility and bile release.

• Evaluate CCK’s role in appetite control and satiety signaling.

• Investigate receptor subtype selectivity (CCK-A vs. CCK-B).

• Serve as control or comparator peptides in CCK-related pharmacological studies.

SNF-8814 has been employed in both in vitro and in vivo experimental models to explore peptide signaling and receptor-mediated cellular responses.

Product Specifications

Mechanism of Action

SNF-8814 exerts its biological effects by acting as a cholecystokinin receptor agonist, mimicking the natural hormone CCK in its interaction with cellular receptors. CCK plays a pivotal role in gastrointestinal regulation and neural signaling.

1. Receptor Binding and Activation

SNF-8814 selectively binds to CCK-A (CCK1) and CCK-B (CCK2) receptors located on gastrointestinal tissues, the pancreas, and the central nervous system. Upon binding, it triggers G-protein-coupled receptor (GPCR) signaling pathways that activate intracellular messengers, including phospholipase C and inositol triphosphate (IP₃), leading to calcium release.

2. Digestive Enzyme Secretion

By activating CCK receptors in the pancreas, SNF-8814 stimulates the release of digestive enzymes such as amylase, lipase, and proteases, enhancing nutrient breakdown and absorption.

3. Gallbladder Contraction and Bile Flow

CCK analogs induce gallbladder smooth muscle contraction, facilitating bile secretion into the small intestine — a key process in lipid digestion.

4. Satiety and Central Signaling

SNF-8814 can influence neural CCK receptors located in the hypothalamus, modulating satiety and feeding behavior. This makes it useful for metabolic and appetite regulation studies.

5. Gastrointestinal Motility Regulation

The compound regulates peristaltic activity and gastric emptying through receptor-mediated calcium signaling in smooth muscle cells.

Through these mechanisms, SNF-8814 serves as a potent research tool for studying CCK physiology, digestive hormone networks, and potential therapeutic targets for gastrointestinal disorders.

Side Effects

As a research peptide, SNF-8814 is not intended for human or animal therapeutic use. Experimental data and analog comparisons suggest the following possible laboratory-observed effects:

• Smooth Muscle Contraction: May induce dose-dependent contractions in gastrointestinal tissue assays.

• Metabolic Alterations: Modulation of pancreatic enzyme levels and bile secretion in animal studies.

• Neurological Effects: Possible central nervous effects when administered systemically in animal models due to CCK-B receptor engagement.

• Gastrointestinal Discomfort: High concentrations may alter gut motility in experimental setups.

• Allergic or Hypersensitivity Reactions: Possible in sensitive models due to peptide-based nature.

Appropriate laboratory handling and concentration control are advised to avoid undesired off-target effects.

Disclaimer

For research use only. Not intended for diagnostic, therapeutic, or veterinary use. Must be handled by trained personnel in accordance with institutional laboratory safety procedures.

Keywords

SNF-8814, CAS 137442-16-1, cholecystokinin analog, CCK receptor agonist, digestive system research, pancreatic secretion, gastrointestinal motility, satiety regulation, gut hormone signaling, GPCR peptide ligand.

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