描述
Product Specifications
Parameter | Details |
---|---|
Product Name | Sodium Valproate Tablets (Dongfangming / Dianjianping) |
Generic Name | Sodium Valproate |
CAS Number | 1069?66?5 |
Molecular Formula | C?H??NaO? |
Molecular Weight | 166.19?g/mol |
Formulation | Oral tablet |
Strength | 200?mg per tablet |
Pack Size | 30 tablets per bottle |
Approval Number | H37022627 (NMPA, China) |
Manufacturer | Shandong Fangming Pharmaceutical Group Co., Ltd. |
Barcode | 6935030540735 |
Storage Conditions | Store in cool, dry place below 30?°C |
Intended Use | For laboratory research only |
Mechanism of Action
Sodium valproate acts through multiple mechanisms:
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Inhibits GABA transaminase and enhances GABA synthesis, increasing inhibitory neurotransmission
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Blocks voltage-gated sodium and T-type calcium channels, reducing neuronal excitability
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Acts as a histone deacetylase (HDAC) inhibitor, modulating gene expression and neuroprotection
Research Applications & Pharmacology
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Epilepsy models: Used in animal models of generalized and partial seizures
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Mood disorder studies: Employed in bipolar and mania assays to study mood stabilization effects .
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Migraine & neuroprotection: Investigated for migraine prophylaxis and neuroinflammation assays
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Epigenetic and cell differentiation: Through HDAC inhibition, used in stem cell, gene expression, and epigenetic remodeling studies
Safety Profile & Handling
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Safety: Generally well-tolerated in preclinical models; notable hepatic and teratogenic effects .
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Adverse effects: GI upset, tremor, weight gain, hair loss, hepatotoxicity, hyperandrogenism
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Lab precautions: Wear PPE; avoid dust/inhalation.
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Storage: Keep tightly sealed, in a dry, cool environment.
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Disposal: Follow institutional chemical waste guidelines.
Core Keywords
sodium valproate tablets, valproate research chemical, CAS?1069-66-5, anticonvulsant lab reagent, mood stabilizer research, HDAC inhibitor reagent, epilepsy study chemical, Dongfangming valproate
Research?Use Disclaimer
For laboratory research use only. Not approved for clinical, therapeutic, diagnostic, or veterinary use. Misuse may pose serious health risks. Follow institutional safety regulations.
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