Description

Product Description

Background

Splenopentin diacetate is a synthetic pentapeptide that mimics amino acid residues 32–36 of the natural splenic hormone splenin. As an immunomodulatory peptide, Splenopentin plays a critical role in regulating the immune system, particularly in T and B lymphocyte differentiation.

Research has shown that administration of Splenopentin diacetate increases the number of antibody-forming cells in murine models exposed to gamma irradiation. This highlights its ability to restore or enhance immune responses in compromised biological systems.

Chemical Nature and Structure

• Peptide Type: Synthetic pentapeptide

• Residues: Corresponds to amino acid sequence 32–36 of splenin

• Form: Diacetate salt (enhances solubility and stability)

• Mechanism: Immunoregulation via lymphocyte maturation pathways

The diacetate form of Splenopentin is generally more soluble in aqueous solutions than the free base, which improves laboratory handling and reproducibility of experimental results.

Research Significance

Splenopentin diacetate has been widely studied in immunology research as a biological response modifier (BRM). It enhances both cellular and humoral immunity, which makes it useful in models of immunodeficiency, bone marrow suppression, or post-irradiation recovery.

Key research areas include:

• T-cell differentiation: Supports thymocyte development into mature T cells.

• B-cell maturation: Promotes early differentiation into antibody-producing plasma cells.

• Immune system recovery: Restores immune competence following radiation or chemotherapy.

• Vaccine response models: Enhances antibody titers in immunization studies.

Comparative Advantage

• High Specificity: Acts directly on immune cell development pathways.

• Stable Salt Form: Diacetate increases solubility and stability.

• Immunomodulatory Potency: Effective in small concentrations.

• Broad Research Applications: Suitable for hematology, oncology, and immunology studies.

Product Specifications

Mechanism of Action & Research Applications

Mechanism of Action

Splenopentin diacetate exerts its biological effects by acting as a mimetic of splenin, a natural thymic-splenic hormone involved in immune regulation. Its pentapeptide structure (residues 32–36) interacts with precursor immune cells to accelerate their differentiation.

• On T lymphocytes: Stimulates thymic-dependent maturation into functional helper and cytotoxic T cells.

• On B lymphocytes: Enhances early differentiation and the ability to form plasma cells, boosting antibody production.

• On irradiated systems: Reconstitutes immune function by restoring bone marrow-derived lymphopoiesis.

Research Applications

1. Immunology Research – Study of immune regulation, cell signaling, and lymphocyte differentiation.

2. Hematopoietic Recovery Models – Exploring immune reconstitution after radiation or chemotherapy.

3. Antibody Production Studies – Evaluating enhancement of vaccine responses.

4. Autoimmune Disease Models – Investigating potential immunoregulatory roles in disease modulation.

5. Oncology Research – Studying immune-enhancing peptides in tumor immunology.

Splenopentin diacetate serves as a valuable research reagent for understanding peptide-driven immunomodulation.

Side Effects (For Reference in Research Models)

In preclinical research, Splenopentin diacetate has shown a favorable safety profile. Reported effects include:

• Mild Injection Site Irritation (in in vivo models)

• Transient Immune Hyperactivation (potentially leading to autoimmunity at high doses)

• Protein Stability Concerns (risk of degradation if not stored properly)

• Species-Specific Variability (differences in immune response depending on animal model)

These findings emphasize the need for careful dosing, storage, and experimental controls in research applications.

Disclaimer

For laboratory research use only. Not for human or veterinary therapeutic use.

Keywords

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• Splenopentin lyophilized powder