Description

Sulanemadlin, also known as ALRN-6924, is a synthetic stapled peptide designed to mimic the N-terminal domain of p53 and block its negative regulators MDM2 and MDMX. By disrupting these protein–protein interactions, Sulanemadlin reactivates p53’s tumor-suppressor functions in cells with wild-type TP53, inducing cell cycle arrest or apoptosis.

Its stabilized ?-helical structure allows for cell permeability and favorable pharmacokinetics, marking it as a pioneering stapled peptide in clinical development. This GMP-produced version (?96.16% purity) is ideal for laboratory studies of cancer biology, DNA damage responses, and chemoprotection mechanisms.

Product Specifications

Mechanism of Action & Research Applications

Sulanemadlin binds with high affinity to both MDM2 and MDMX, preventing these proteins from inhibiting p53. This restoration of p53 activity leads to apoptosis or cell-cycle arrest in TP53 wild-type cancer models. Key research applications include:

• Investigating p53 signaling pathways in oncology

• Evaluating chemoprotective strategies by transient p53 activation in healthy tissues

• Developing stapled peptide-based therapeutics targeting protein–protein interactions

Side Effects (For Research Context Only)

In experimental systems, Sulanemadlin may:

• Induce p53-dependent cell cycle arrest or apoptosis

• Enhance sensitivity to DNA-damaging agents

• Modulate cell survival in normal tissue during stress models

These observations are limited to controlled laboratory studies.

Disclaimer

Sulanemadlin is strictly for laboratory research use only. This product is not approved for human or veterinary use. Please adhere to institutional handling protocols.